INT7170

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Context Info
Confidence 0.40
First Reported 1992
Last Reported 1992
Negated 0
Speculated 2
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 4.76

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peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb)
extracellular region (Ctsb) response to stress (Ctsb) lysosome (Ctsb)
Ctsb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 92 99.84 Very High Very High Very High
Enkephalin 24 99.20 Very High Very High Very High
antagonist 8 92.84 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that the ME production by BK or des-Arg9-BK may be mediated by Ca(2+)-dependent cathepsin B activation through B1-receptors and IAP-sensitive G-proteins, whereas the production by L-Arg may be mediated by Ca(2+)-dependent cathepsin B activation through kyotorphin-receptor and Botulinum C3-enzyme-sensitive G-proteins.
Spec (may) Positive_regulation (mediated) of Positive_regulation (activation) of cathepsin B associated with enkephalin and bradykinin
1) Confidence 0.40 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.19
These results suggest that the ME production by BK or des-Arg9-BK may be mediated by Ca(2+)-dependent cathepsin B activation through B1-receptors and IAP-sensitive G-proteins, whereas the production by L-Arg may be mediated by Ca(2+)-dependent cathepsin B activation through kyotorphin-receptor and Botulinum C3-enzyme-sensitive G-proteins.
Positive_regulation (-dependent) of Positive_regulation (activation) of cathepsin B associated with enkephalin and bradykinin
2) Confidence 0.40 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.18
These results suggest that the ME production by BK or des-Arg9-BK may be mediated by Ca(2+)-dependent cathepsin B activation through B1-receptors and IAP-sensitive G-proteins, whereas the production by L-Arg may be mediated by Ca(2+)-dependent cathepsin B activation through kyotorphin-receptor and Botulinum C3-enzyme-sensitive G-proteins.
Positive_regulation (-dependent) of Positive_regulation (activation) of cathepsin B associated with enkephalin and bradykinin
3) Confidence 0.40 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.19
These results suggest that the ME production by BK or des-Arg9-BK may be mediated by Ca(2+)-dependent cathepsin B activation through B1-receptors and IAP-sensitive G-proteins, whereas the production by L-Arg may be mediated by Ca(2+)-dependent cathepsin B activation through kyotorphin-receptor and Botulinum C3-enzyme-sensitive G-proteins.
Spec (may) Positive_regulation (mediated) of Positive_regulation (activation) of cathepsin B associated with enkephalin and bradykinin
4) Confidence 0.40 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.20

General Comments

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