INT71716

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Context Info
Confidence 0.28
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 6.54
Pain Relevance 4.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hbegf) extracellular region (Hbegf) plasma membrane (Hbegf)
Anatomy Link Frequency
urine 5
fibroblast 2
urothelial cells 2
epithelial cell 1
HGF 1
Hbegf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
interstitial cystitis 73 99.38 Very High Very High Very High
metalloproteinase 10 99.26 Very High Very High Very High
lidocaine 14 98.64 Very High Very High Very High
antagonist 1 93.60 High High
Cannabinoid receptor 1 88.60 High High
cOX1 2 77.64 Quite High
sodium channel 2 75.04 Quite High
Cannabinoid 3 75.00 Quite High
Inflammation 100 73.52 Quite High
Pain 11 63.04 Quite High
Disease Link Frequency Relevance Heat
Cancer 26 99.80 Very High Very High Very High
Necrosis 6 99.56 Very High Very High Very High
Interstitial Cystitis 73 99.38 Very High Very High Very High
Injury 135 98.30 Very High Very High Very High
Overactive Bladder 1 97.92 Very High Very High Very High
Lung Cancer 1 76.84 Quite High
Glioblastoma 1 75.20 Quite High
INFLAMMATION 145 73.52 Quite High
Shock 2 70.84 Quite High
Skin Cancer 1 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tarnawski et al. [28] previously reported that rebamipide significantly upregulated the proangiogenic genes encoding vascular endothelial growth factor (VEGF), heparin binding epidermal growth-like factor (HB-EGF), fibroblast growth factor receptor-2 (FGFR2), and cyclooxygenase-2 (Cox2), as well as growth promoting genes, including insulin growth factor-1 (IGF-1).
epidermal growth-like factor Binding (binding) of in fibroblast
1) Confidence 0.28 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243244 Disease Relevance 0.32 Pain Relevance 0.07
Tarnawski et al. [28] previously reported that rebamipide significantly upregulated the proangiogenic genes encoding vascular endothelial growth factor (VEGF), heparin binding epidermal growth-like factor (HB-EGF), fibroblast growth factor receptor-2 (FGFR2), and cyclooxygenase-2 (Cox2), as well as growth promoting genes, including insulin growth factor-1 (IGF-1).
HB-EGF Binding (binding) of in fibroblast
2) Confidence 0.28 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243244 Disease Relevance 0.32 Pain Relevance 0.07
Urine from patients with interstitial cystitis has been shown to inhibit urothelial proliferation through a putative antiproliferative factor and to contain decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) compared to controls.
HB-EGF Binding (binding) of in Urine associated with interstitial cystitis
3) Confidence 0.26 Published 2000 Journal J. Urol. Section Abstract Doc Link 10751853 Disease Relevance 0.45 Pain Relevance 0.43
Urine specimens were collected at these two time points and measured for heparin-binding epidermal growth factor-like growth factor (HB-EGF) by enzyme-linked immunosorbent assay and for antiproliferative factor (APF) activity by (3)H-thymidine uptake by normal human bladder urothelial cells.
HB-EGF Binding (binding) of in urothelial cells
4) Confidence 0.23 Published 2000 Journal Urology Section Body Doc Link 10792070 Disease Relevance 0.16 Pain Relevance 0
Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF).
HB-EGF Binding (heparin-binding) of associated with cancer and lidocaine
5) Confidence 0.22 Published 2002 Journal J. Cell. Physiol. Section Title Doc Link 12124780 Disease Relevance 0.32 Pain Relevance 0.56
Ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF) from the cell surface plays an important role in invasion by HT1080 cells.
HB-EGF Binding (heparin-binding) of
6) Confidence 0.22 Published 2002 Journal J. Cell. Physiol. Section Abstract Doc Link 12124780 Disease Relevance 0.29 Pain Relevance 0.49
Antiproliferative factor (APF) activity was determined by 3H-thymidine incorporation assay; heparin-binding epidermal growth factor-like growth factor (HB-EGF) and epidermal growth factor-like growth factor (EGF) levels were determined by ELISA.
HB-EGF Binding (heparin-binding) of
7) Confidence 0.22 Published 2007 Journal World J Urol Section Abstract Doc Link 17694391 Disease Relevance 0.25 Pain Relevance 0.25
Antiproliferative factor (APF) activity was determined by 3H-thymidine incorporation assay; heparin-binding epidermal growth factor-like growth factor (HB-EGF) and epidermal growth factor-like growth factor (EGF) levels were determined by ELISA.
heparin-binding epidermal growth factor-like growth factor Binding (heparin-binding) of
8) Confidence 0.22 Published 2007 Journal World J Urol Section Abstract Doc Link 17694391 Disease Relevance 0.25 Pain Relevance 0.25
Antiproliferative factor (APF) activity was determined by 3H-thymidine incorporation assay; heparin-binding epidermal growth factor-like growth factor (HB-EGF) and epidermal growth factor-like growth factor (EGF) levels were determined by ELISA.
HB-EGF Binding (heparin-binding) of
9) Confidence 0.22 Published 2007 Journal World J Urol Section Abstract Doc Link 17694391 Disease Relevance 0.25 Pain Relevance 0.25
We previously identified an interstitial cystitis urine factor, antiproliferative factor, that inhibits proliferation of bladder epithelial cells in vitro and complex changes in epithelial growth factor levels, including profound decreases in heparin-binding epidermal growth factor-like growth factor (HB-EGF).
HB-EGF Binding (heparin-binding) of in urine associated with interstitial cystitis
10) Confidence 0.19 Published 2000 Journal J. Urol. Section Abstract Doc Link 11061938 Disease Relevance 0.44 Pain Relevance 0.50
Urine specimens were collected at these two time points and measured for heparin-binding epidermal growth factor-like growth factor (HB-EGF) by enzyme-linked immunosorbent assay and for antiproliferative factor (APF) activity by (3)H-thymidine uptake by normal human bladder urothelial cells.
HB-EGF Binding (heparin-binding) of in urothelial cells
11) Confidence 0.18 Published 2000 Journal Urology Section Body Doc Link 10792070 Disease Relevance 0.16 Pain Relevance 0
Pretreatment of IC BUCs with 20 ng/ml of heparin-binding EGF-like growth factor (HB-EGF), which previously has been shown to be decreased in IC urine specimens, also restored IC BUCs to a control phenotype with respect to response to ATP stimulation.
HB-EGF Spec (like) Binding (binding) of in urine associated with interstitial cystitis
12) Confidence 0.13 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16107499 Disease Relevance 1.15 Pain Relevance 1.20
Similar inhibition of the proliferation rate was seen in control cells treated with APF; APF-induced changes in heparin-binding epidermal growth factor-like growth factor, but not epidermal growth factor, production by cells were associated with changes in growth rates.
epidermal growth factor-like growth factor Binding (binding) of
13) Confidence 0.11 Published 2003 Journal Urology Section Body Doc Link 12809929 Disease Relevance 0.07 Pain Relevance 0
This abnormality may be caused by APF, which induces reversible inhibition of heparin-binding epidermal growth factor-like growth factor production and normal bladder epithelial cell proliferation.


epidermal growth factor-like growth factor Binding (binding) of in epithelial cell
14) Confidence 0.11 Published 2003 Journal Urology Section Body Doc Link 12809929 Disease Relevance 0 Pain Relevance 0
Heparin-binding epidermal growth factor-like growth factor and epidermal growth factor were measured by enzyme-linked immunosorbent assay.
epidermal growth factor-like growth factor Binding (binding) of
15) Confidence 0.11 Published 2003 Journal Urology Section Body Doc Link 12809929 Disease Relevance 0.08 Pain Relevance 0
In other tissues muscarinic receptors activate a metalloproteinase, which liberates surface-associated heparin-binding epidermal growth factor (HB-EGF) and causes transactivation of epidermal growth factor receptors (EGFRs) with activation of PI3-kinase.
HB-EGF Binding (heparin-binding) of associated with metalloproteinase
16) Confidence 0.09 Published 2004 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15010282 Disease Relevance 0 Pain Relevance 0.12
In other tissues muscarinic receptors activate a metalloproteinase, which liberates surface-associated heparin-binding epidermal growth factor (HB-EGF) and causes transactivation of epidermal growth factor receptors (EGFRs) with activation of PI3-kinase.
HB-EGF Binding (heparin-binding) of associated with metalloproteinase
17) Confidence 0.09 Published 2004 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15010282 Disease Relevance 0 Pain Relevance 0.12
CONCLUSIONS: These findings indicate that complex changes in the levels of urine epithelial cell growth factors (EGF, IGF1, and HB-EGF) and a growth factor binding protein (IGFBP3) are associated with IC.
HB-EGF Binding (associated) of in urine
18) Confidence 0.06 Published 1997 Journal J. Urol. Section Body Doc Link 9334654 Disease Relevance 0.05 Pain Relevance 0
CONCLUSIONS: This study confirmed several previously reported urine alterations in interstitial cystitis, including increased anti-proliferative factor, epidermal growth factor, IGF binding protein-3 and IL-6, and decreased heparin-binding epidermal growth factor-like growth factor and cyclic guanosine monophosphate.
epidermal growth factor-like growth factor Binding (heparin-binding) of in urine
19) Confidence 0.05 Published 2002 Journal J. Urol. Section Body Doc Link 11992058 Disease Relevance 0 Pain Relevance 0
Markers significantly decreased in interstitial cystitis were heparin-binding epidermal growth factor-like growth factor, cyclic guanosine monophosphate and methylhistamine.
epidermal growth factor-like growth factor Binding (binding) of
20) Confidence 0.05 Published 2002 Journal J. Urol. Section Body Doc Link 11992058 Disease Relevance 0 Pain Relevance 0

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