INT71717

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Context Info
Confidence 0.39
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 3.63
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Hbegf) extracellular region (Hbegf) plasma membrane (Hbegf)
Anatomy Link Frequency
urine 10
Hbegf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
interstitial cystitis 66 99.84 Very High Very High Very High
metalloproteinase 10 97.04 Very High Very High Very High
antagonist 1 92.32 High High
Cannabinoid receptor 1 90.32 High High
Cannabinoid 3 75.00 Quite High
Pain 1 64.76 Quite High
MU agonist 2 50.24 Quite High
pain pelvic 4 50.00 Quite Low
Enkephalin 2 47.68 Quite Low
cytokine 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Interstitial Cystitis 66 99.84 Very High Very High Very High
Cancer 7 99.80 Very High Very High Very High
Necrosis 2 99.56 Very High Very High Very High
Overactive Bladder 2 97.92 Very High Very High Very High
Lung Cancer 1 78.56 Quite High
Glioblastoma 1 76.92 Quite High
Apoptosis 2 69.04 Quite High
Pain 1 64.76 Quite High
Vomiting 2 64.36 Quite High
Immunotherapy Of Cancer 1 63.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APF positivity, decreased HB-EGF, increased EGF, and increased HDF were confirmed at baseline in IC patients.
Negative_regulation (decreased) of HB-EGF associated with interstitial cystitis
1) Confidence 0.39 Published 2007 Journal World J Urol Section Abstract Doc Link 17694391 Disease Relevance 0.28 Pain Relevance 0.28
Urine from patients with interstitial cystitis has been shown to inhibit urothelial proliferation through a putative antiproliferative factor and to contain decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) compared to controls.
Negative_regulation (decreased) of HB-EGF in Urine associated with interstitial cystitis
2) Confidence 0.32 Published 2000 Journal J. Urol. Section Abstract Doc Link 10751853 Disease Relevance 0.45 Pain Relevance 0.43
These results provide additional evidence for the possible role of antiproliferative factor and decreased HB-EGF in the pathophysiology of interstitial cystitis.
Negative_regulation (decreased) of HB-EGF
3) Confidence 0.32 Published 2000 Journal J. Urol. Section Body Doc Link 10751853 Disease Relevance 0 Pain Relevance 0
We previously identified an interstitial cystitis urine factor, antiproliferative factor, that inhibits proliferation of bladder epithelial cells in vitro and complex changes in epithelial growth factor levels, including profound decreases in heparin-binding epidermal growth factor-like growth factor (HB-EGF).
Negative_regulation (decreases) of HB-EGF in urine associated with interstitial cystitis
4) Confidence 0.30 Published 2000 Journal J. Urol. Section Abstract Doc Link 11061938 Disease Relevance 0.44 Pain Relevance 0.50
APF positivity, decreased HB-EGF, increased EGF, and increased HDF were confirmed at baseline in IC patients.
Negative_regulation (decreased) of HB-EGF associated with interstitial cystitis
5) Confidence 0.28 Published 2007 Journal World J Urol Section Abstract Doc Link 17694391 Disease Relevance 0.28 Pain Relevance 0.28
Furthermore, decreased levels of urine and serum HB-EGF indicate that interstitial cystitis may be a urinary tract manifestation of a systemic disorder.


Negative_regulation (decreased) of HB-EGF in urine
6) Confidence 0.26 Published 2000 Journal J. Urol. Section Body Doc Link 11061938 Disease Relevance 0 Pain Relevance 0
Pretreatment of IC BUCs with 20 ng/ml of heparin-binding EGF-like growth factor (HB-EGF), which previously has been shown to be decreased in IC urine specimens, also restored IC BUCs to a control phenotype with respect to response to ATP stimulation.
Negative_regulation (decreased) of HB-EGF in urine associated with interstitial cystitis
7) Confidence 0.16 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16107499 Disease Relevance 1.05 Pain Relevance 1.09
CRM-197, which inhibits HB-EGF activity, also blocked ACh-induced ROS generation, again implicating release of HB-EGF as a necessary step for ROS generation.
Negative_regulation (inhibits) of HB-EGF
8) Confidence 0.14 Published 2004 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15010282 Disease Relevance 0 Pain Relevance 0.21
In contrast, APF activity was present significantly more often and HB-EGF levels were significantly lower in the urine specimens from men with IC than in the specimens from controls or patients with CP/CPPS (P <0.00001 for all four comparisons).
Negative_regulation (lower) of HB-EGF in urine
9) Confidence 0.13 Published 2004 Journal Urology Section Body Doc Link 14751340 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: These findings indicate that at least two of the urine biomarkers previously identified in women with IC (presence of APF activity and decreased levels of HB-EGF) are also found in men with IC, but not in men with CP/CPPS.
Negative_regulation (decreased) of HB-EGF in urine
10) Confidence 0.12 Published 2004 Journal Urology Section Body Doc Link 14751340 Disease Relevance 0 Pain Relevance 0
While EGF, IGF1, and IGFBP3 levels are either the same or increased in the urine of IC patients as compared to patients with bacterial cystitis or asymptomatic controls, HB-EGF levels are significantly decreased in the urine of IC patients.
Negative_regulation (decreased) of HB-EGF in urine
11) Confidence 0.10 Published 1997 Journal J. Urol. Section Body Doc Link 9334654 Disease Relevance 0 Pain Relevance 0
CRM-197, which inhibits HB-EGF activity, also blocked ACh-induced ROS generation, again implicating release of HB-EGF as a necessary step for ROS generation.
Negative_regulation (inhibits) of HB-EGF
12) Confidence 0.10 Published 2004 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15010282 Disease Relevance 0 Pain Relevance 0.21
While EGF, IGF1, and IGFBP3 levels are either the same or increased in the urine of IC patients as compared to patients with bacterial cystitis or asymptomatic controls, HB-EGF levels are significantly decreased in the urine of IC patients.
Negative_regulation (decreased) of HB-EGF in urine
13) Confidence 0.08 Published 1997 Journal J. Urol. Section Body Doc Link 9334654 Disease Relevance 0 Pain Relevance 0
RESULTS: Urine HB-EGF levels were specifically and significantly decreased in IC patients as compared to asymptomatic controls or patients with bacterial cystitis, whether expressed as concentration (amount per volume of urine) or the amount relative to urine creatinine in each specimen.
Negative_regulation (decreased) of HB-EGF in Urine
14) Confidence 0.07 Published 1997 Journal J. Urol. Section Body Doc Link 9334654 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: This study confirmed several previously reported urine alterations in interstitial cystitis, including increased anti-proliferative factor, epidermal growth factor, IGF binding protein-3 and IL-6, and decreased heparin-binding epidermal growth factor-like growth factor and cyclic guanosine monophosphate.
Negative_regulation (decreased) of epidermal growth factor-like growth factor in urine
15) Confidence 0.06 Published 2002 Journal J. Urol. Section Body Doc Link 11992058 Disease Relevance 0 Pain Relevance 0
Depending on the cellular context, signal cross-communication was mediated by shedding of proAmphiregulin (proAR) and/or proHeparin-binding epidermal growth factor-like growth factor (proHB-EGF) by tumor necrosis factor alpha converting enzyme (TACE/ADAM17).
Negative_regulation (shedding) of proHB-EGF associated with necrosis and cancer
16) Confidence 0.00 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15026328 Disease Relevance 1.05 Pain Relevance 0.18

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