INT71727

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 25
Total Number 26
Disease Relevance 17.76
Pain Relevance 5.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
plasma 7
Synovial fluid 1
epithelial cell 1
dura mater 1
blood 1
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 15 99.20 Very High Very High Very High
chemokine 6 99.16 Very High Very High Very High
cINOD 14 98.78 Very High Very High Very High
rheumatoid arthritis 48 98.48 Very High Very High Very High
cytokine 83 98.40 Very High Very High Very High
Angina 18 97.84 Very High Very High Very High
endometriosis 10 97.80 Very High Very High Very High
Pain score 4 97.48 Very High Very High Very High
Inflammation 190 96.68 Very High Very High Very High
ischemia 106 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Adhesions 126 100.00 Very High Very High Very High
Necrosis 24 100.00 Very High Very High Very High
Urological Neuroanatomy 15 100.00 Very High Very High Very High
Cancer 15 100.00 Very High Very High Very High
Infarction 2 100.00 Very High Very High Very High
Myocardial Infarction 18 99.36 Very High Very High Very High
INFLAMMATION 210 99.20 Very High Very High Very High
Apoptosis 225 98.72 Very High Very High Very High
Rheumatoid Arthritis 49 98.48 Very High Very High Very High
Coronary Artery Disease 19 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The decreased ICAM-1 and VCAM-1 levels after intra-articular HA injection may help to explain the anti-inflammatory effects of HA therapy in knee OA.
Negative_regulation (decreased) of ICAM-1 in knee associated with inflammation and osteoarthritis
1) Confidence 0.45 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.92 Pain Relevance 0.42
Synovial fluid levels of both ICAM-1 and VCAM-1 were significantly reduced at weeks 1 to 3, compared to the baseline values.
Negative_regulation (reduced) of ICAM-1 in Synovial fluid
2) Confidence 0.45 Published 2004 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 15487709 Disease Relevance 0.79 Pain Relevance 0.32
In patients with AMI, the levels of sE-selectin and sICAM-1 increased significantly during the first 8 h after infarction and subsequently decreased.
Negative_regulation (decreased) of sICAM-1 associated with infarction and myocardial infarction
3) Confidence 0.43 Published 1997 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9335404 Disease Relevance 1.02 Pain Relevance 0.20
The blocking ICAM-1 and P-selectin MAbs both inhibited Indo-induced increases in lesion score, mucosal permeability, and epithelial cell necrosis.
Negative_regulation (blocking) of ICAM-1 in epithelial cell associated with necrosis
4) Confidence 0.42 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9486176 Disease Relevance 0.58 Pain Relevance 0.38
We found Curcumin decreased the levels of D-lactate, DAO, MPO, ICAM-1, IL-1?
Negative_regulation (decreased) of ICAM associated with urological neuroanatomy
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2945766 Disease Relevance 0.81 Pain Relevance 0.10
In group 1A, the ICAM-1 decreased significantly at second blood samplings (310 +/- 28 vs 368 +/- 30 ng/ml; p <0.001), whereas in group 1B there was no significant change in ICAM-1 (357 +/- 33 vs 359 +/- 26 ng/ml; p = NS).
Negative_regulation (decreased) of ICAM-1 in blood
6) Confidence 0.32 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9416930 Disease Relevance 0.24 Pain Relevance 0.24
In the acute phase of MI (a) sE-selectin and sICAM-1 levels increase during the first 8 h and subsequently decrease; (b) the increase in sE-selectin probably reflects activation of endothelial cells, correlates with other inflammatory and coagulation parameters, and is inversely related to the degree of myocardial damage; and (c) sICAM-1 plasma levels do not represent a good marker of "cell activation" because they reflect activation of different cells and may be affected by different conditions.
Negative_regulation (decrease) of sICAM-1 in plasma associated with inflammation
7) Confidence 0.31 Published 1997 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9335404 Disease Relevance 0.92 Pain Relevance 0.23
Indeed, down-regulation of ICAM-1 on vascular endothelial cells can attenuate hepatic I/Ri both in vitro and in vivo [42,43].
Negative_regulation (regulation) of ICAM-1 in endothelial cells
8) Confidence 0.23 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 0.31 Pain Relevance 0.11
Plasma levels of both IL-6 and ICAM-1 were reduced in patients taking aspirin.
Negative_regulation (reduced) of ICAM-1 in Plasma
9) Confidence 0.21 Published 2002 Journal Eur. J. Clin. Invest. Section Body Doc Link 12534448 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: Preexisting statin therapy plays a role in reducing the serum levels of CRP, ICAM-1, and anti-oxLDL Ab after coronary stenting in patients with unstable angina.
Negative_regulation (reducing) of ICAM-1
10) Confidence 0.20 Published 2005 Journal Clin Cardiol Section Body Doc Link 15757077 Disease Relevance 0.05 Pain Relevance 0
NO modulates leukocyte adhesion in the microcirculation by decreasing the binding of PMN to the adhesion molecules E-selectin and ICAM-1 [22,24].
Negative_regulation (decreasing) of ICAM-1 in leukocyte associated with adhesions
11) Confidence 0.19 Published 2006 Journal BMC Nephrol Section Body Doc Link PMC1501003 Disease Relevance 1.06 Pain Relevance 0.34
It displays its effect on protecting vascular endothelia and anti-angina pectoris partially by decreasing the plasma levels of ET, vWF, sVCAM-1 and sICAM-1 and elevating the level of NO.


Negative_regulation (decreasing) of sICAM-1 in plasma
12) Confidence 0.16 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0 Pain Relevance 0
RESULTS: (1) The clinical symptoms as frequency and persistent time of angina pectoris in the treated group were bettered significantly after treatment and the dosage of nitroglycerin used decreased (all P < 0.01), showing significant difference when compared with those in the control group (P < 0.05). (2) The effective rates on UAP symptoms and ECG in the treated group were 86.7% and 76.7% respectively, which were significantly higher than those in the control group (70.0% and 63.3%, P < 0.05). (3) Laboratory examination showed in the control group, changes only displayed in the decrease of vWF and ET and increase of NO (all P < 0.05), while in the treated group, plasma levels of vWF, ET, sVCAM-1 and sICAM-1 after treatment significantly decreased and were lower than those in the control group (P < 0.01), but NO elevated significantly and was higher than that in the control group (P < 0.01).
Negative_regulation (decreased) of sICAM-1 in plasma
13) Confidence 0.16 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0 Pain Relevance 0
Further, we demonstrate that inhibition of ICAM-1 by piperine is reversible.
Negative_regulation (inhibition) of ICAM-1
14) Confidence 0.15 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17764673 Disease Relevance 0.86 Pain Relevance 0.15
inhibition decreases intercellular adhesion molecule 1 (ICAM-1) levels and NF-?
Negative_regulation (decreases) of intercellular adhesion molecule 1 associated with adhesions
15) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.72 Pain Relevance 0.11
inhibition decreases intercellular adhesion molecule 1 (ICAM-1) levels and NF-?
Negative_regulation (decreases) of ICAM-1 associated with adhesions
16) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.72 Pain Relevance 0.11
Plasma sICAM-1 decreased during an early stage after CABG with CPB, recovering at 4 hours after reperfusion; and a significant increase in ICAM-1 was observed 20 hours later.
Negative_regulation (decreased) of sICAM-1 in Plasma
17) Confidence 0.11 Published 2003 Journal World J Surg Section Abstract Doc Link 12616425 Disease Relevance 0.59 Pain Relevance 0.11
The progressive decrease in sICAM-1 levels during attacks and the down-regulation of LFA-1 expression by lymphocytes could antagonize their transvascular migration, supporting the hypothesis of sterile inflammation in the dura mater during migraine attacks.


Negative_regulation (decrease) of sICAM-1 in dura mater
18) Confidence 0.10 Published 2006 Journal Headache Section Body Doc Link 16492228 Disease Relevance 0.05 Pain Relevance 0
After up to 24 hours in culture, protein and mRNA expression of ICAM-1 was monitored using ELISA and real-time PCR, respectively.
Negative_regulation (monitored) of ICAM-1
19) Confidence 0.08 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2817554 Disease Relevance 0.50 Pain Relevance 0.11
After GnRHa therapy, all patients showed significant decreases in mean concentrations of VEGF (194+/-77 pg/ml), TGF-beta (902+/-273 pg/ml) and ICAM-1 (157+/-52 ng/ml).
Negative_regulation (decreases) of ICAM-1
20) Confidence 0.08 Published 1998 Journal Hum. Reprod. Update Section Abstract Doc Link 10027625 Disease Relevance 0.88 Pain Relevance 0.48

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