INT71732

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 2.00
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGAM) plasma membrane (ITGAM)
Anatomy Link Frequency
macrophages 1
plasma 1
leukocyte 1
ITGAM (Homo sapiens)
Pain Link Frequency Relevance Heat
local anesthetic 1 98.72 Very High Very High Very High
reflex sympathetic dystrophy 7 98.04 Very High Very High Very High
Inflammation 12 92.16 High High
Pain 2 87.72 High High
Catecholamine 1 77.52 Quite High
ischemia 18 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Clonidine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 8 100.00 Very High Very High Very High
Stress 6 99.40 Very High Very High Very High
Complex Regional Pain Syndromes 7 98.04 Very High Very High Very High
Inflammatory Bowel Disease 1 95.88 Very High Very High Very High
INFLAMMATION 14 92.16 High High
Pain 2 87.72 High High
Cancer 1 53.24 Quite High
Necrosis 2 53.00 Quite High
Stroke 20 5.00 Very Low Very Low Very Low
Transient Ischemic Attack 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As compared with healthy volunteers, the following major alterations in CRPS patients were found: (I) elevated stress score (PTSS-10) and stress hormone concentrations, (II) decreased expression of the CD62L and CD11b/CD18 on neutrophils, (III) impaired ability of autologous plasma to enhance the capability of neutrophils to phagocytose zymosan particles, and (IV) a negative correlation between PTSS-10 values and autologous plasma enhanced phagocytosis.
Negative_regulation (decreased) of CD11b in plasma associated with stress and reflex sympathetic dystrophy
1) Confidence 0.41 Published 2007 Journal Clin. Immunol. Section Abstract Doc Link 17702656 Disease Relevance 1.22 Pain Relevance 0.81
The number of CD11b+ macrophages in the agmatine treatment group was significantly decreased to 39,213,403.88±23,167,840.6, and the number of CD11b+-positive cells per unit volume was decreased to 95.65±38.87 cells/mm3 compared to the experimental control group (Fig. 4B, C).


Negative_regulation (decreased) of CD11b in macrophages
2) Confidence 0.41 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998779 Disease Relevance 0 Pain Relevance 0
Ropivacaine inhibits leukocyte rolling, adhesion and CD11b/CD18 expression.
Negative_regulation (inhibits) of CD11b/CD18 in leukocyte associated with adhesions
3) Confidence 0.20 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9336308 Disease Relevance 0.78 Pain Relevance 0.19

General Comments

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