INT71747

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Context Info
Confidence 0.46
First Reported 1997
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 19
Total Number 60
Disease Relevance 8.76
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2)
protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)
Anatomy Link Frequency
respiratory 6
hypothalamus 3
skeletal muscle 3
STO 3
arcuate nucleus 1
Prkaa2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 57 94.04 High High
qutenza 42 93.04 High High
Intracerebroventricular 70 86.68 High High
anesthesia 31 82.32 Quite High
Inflammation 20 79.60 Quite High
Inflammatory mediators 2 74.52 Quite High
Kinase C 42 64.68 Quite High
Osteoarthritis 21 50.00 Quite Low
agonist 14 35.48 Quite Low
imagery 84 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 924 99.98 Very High Very High Very High
Obesity 552 98.92 Very High Very High Very High
Appetite Loss 196 98.76 Very High Very High Very High
Shock 42 98.72 Very High Very High Very High
Hepatocellular Cancer 42 94.12 High High
Parkinson's Disease 84 93.84 High High
Hypoxia 42 93.24 High High
Targeted Disruption 42 92.12 High High
Diabetes Mellitus 44 91.92 High High
Aging 14 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, settings of activation of AMPK or inactivation of mTOR were selected to induce changes in target protein phosphorylation, but not food intake.
Positive_regulation (activation) of AMPK
1) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.27 Pain Relevance 0
In the hypothalamus, activation of AMPK leads to increased feeding, thereby increasing energy intake.
Positive_regulation (activation) of AMPK in hypothalamus
2) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.12 Pain Relevance 0
In peripheral tissues, such as skeletal muscle, activation of AMPK switches on energy producing pathways and switches off energy consuming pathways.
Positive_regulation (activation) of AMPK in skeletal muscle
3) Confidence 0.46 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.13 Pain Relevance 0
Exercise induces a decline in skeletal muscle malonyl-CoA, which is accompanied by inactivation of ACC and increased activity of AMP-activated protein kinase (AMPK).
Positive_regulation (increased) of AMPK in skeletal muscle
4) Confidence 0.40 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9338417 Disease Relevance 0 Pain Relevance 0.08
Furthermore, fasting and the use of another activator of AMPK (2-DG) in exercising rats resulted in a lower activation of AMPK when compared to the control animals.
Positive_regulation (activation) of AMPK
5) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.17 Pain Relevance 0
6 M) to rats pretreated with AICAR increased both AMPK and ACC phosphorylation levels in the hypothalamus (Figures 8b and c).
Positive_regulation (increased) of AMPK in hypothalamus
6) Confidence 0.40 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.11 Pain Relevance 0
Similar results were observed after intraperitoneal treatment with 2-DG, another pharmacological activator of AMPK (Figure 3f–j).
Positive_regulation (activator) of AMPK
7) Confidence 0.33 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0
Double-staining confocal microscopy showed the positive immunoreactivity of IL-6R and AMPK in the hypothalamic arcuate nucleus of rats 60 minutes after i.c.v. saline or IL-6 (200 ng) infusion.
Positive_regulation (immunoreactivity) of AMPK in arcuate nucleus
8) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.16 Pain Relevance 0
In addition, AMPK activity is diminished in IL-6 deficient mice at rest and the absolute increases in AMPK activity in these tissues caused by exercise is diminished compared with control mice [27].
Positive_regulation (increases) of AMPK
9) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.09 Pain Relevance 0.03
Once activated, AMPK phosphorylates acetyl-CoA carboxylase (ACC) and switches on energy-producing pathways at the expense of energy-depleting processes [10]–[12].
Positive_regulation (activated) of AMPK
10) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.28 Pain Relevance 0
Exercise induces a decline in skeletal muscle malonyl-CoA, which is accompanied by inactivation of ACC and increased activity of AMP-activated protein kinase (AMPK).
Positive_regulation (inactivation) of AMPK in skeletal muscle
11) Confidence 0.29 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9338417 Disease Relevance 0 Pain Relevance 0.08
AMPK activity increased more than twofold.
Positive_regulation (increased) of AMPK
12) Confidence 0.29 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9338417 Disease Relevance 0 Pain Relevance 0.08
The administration of AICAR increased AMPK threonine and ACC serine phosphorylation, although at this dose, AICAR was not sufficient to induce significant an increase in food intake in exercised animals (data not shown).
Positive_regulation (increased) of AMPK
13) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.24 Pain Relevance 0
Treatment with leptin markedly reduced food intake, AMPK activity and increased mTOR activity in exercised rats that were pretreated with vehicle, although no increase in response to leptin-induced anorexia and modulation of AMPK/mTOR pathway were detected after i.c.v. pretreatment with anti-IL-6 antibody.
Neg (no) Positive_regulation (increase) of AMPK associated with appetite loss
14) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.17 Pain Relevance 0
The level of circulating interleukin-6 (IL-6) increases dramatically in response to exercise [21], with IL-6 being produced by working muscle [22], [23] and adipose tissue [24], [25] and its concentration correlates temporally with increases in AMPK in multiple tissues [26].
Positive_regulation (increases) of AMPK in adipose tissue associated with obesity
15) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.10 Pain Relevance 0
Treatment with leptin markedly reduced food intake, AMPK activity and increased mTOR activity in exercised rats that were pretreated with vehicle, although no increase in response to leptin-induced anorexia and modulation of AMPK/mTOR pathway were detected after i.c.v. pretreatment with anti-IL-6 antibody.
Positive_regulation (increased) of AMPK associated with appetite loss
16) Confidence 0.27 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.16 Pain Relevance 0
Furthermore, the reduction of AMPK and ACC phosphorylation and increase in phosphorylation of proteins involved in mTOR signal transduction, observed in the hypothalamus after leptin infusion, were more pronounced in both lean and diet-induced obesity rats after acute exercise.
Positive_regulation (increase) of AMPK in hypothalamus associated with obesity
17) Confidence 0.27 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2585815 Disease Relevance 0.26 Pain Relevance 0.04
M) of the Ca2+ ionophore A23187 progressively increased AMPK activity, and the effect of either concentration was completely blocked by STO-609.
Positive_regulation (increased) of AMPK in STO
18) Confidence 0.23 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.09 Pain Relevance 0
Interestingly, AMPK activation in response to phenformin or galegine was not blocked by quinidine, indicating that their cellular uptake is not dependent on the transporter.
Positive_regulation (activation) of AMPK
19) Confidence 0.23 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.06 Pain Relevance 0
subunit (Gledhill et al., 2007), and our results support the idea that it activates AMPK via this mechanism.
Positive_regulation (activates) of AMPK
20) Confidence 0.23 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.09 Pain Relevance 0.03

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