INT71750

Context Info Confidence 0.41 First Reported 1997 Last Reported 2010 Negated 4 Speculated 1 Reported most in Body Documents 12 Total Number 14 Disease Relevance 2.98 Pain Relevance 0.29

nucleoplasm (Prkaa2) nucleus (Prkaa2) protein binding, bridging (Prkaa2) protein complex (Prkaa2) response to stress (Prkaa2) cytoplasm (Prkaa2)

Anatomy Link Frequency hypothalamus 5 skeletal muscle 1 respiratory 1 body 1 Prkaa2 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 11 99.96 cytokine 13 99.84 Intracerebroventricular 55 99.38 anesthesia 23 92.88 qutenza 2 35.76 imagery 4 5.00 Kinase C 2 5.00

Disease Link Frequency Relevance Heat Stress 44 99.08 Obesity 429 96.32 Hypoxia 2 95.92 Appetite Loss 154 94.64 Shock 2 90.36 Body Weight 44 66.40 Aging 11 62.96 Cancer 2 37.12 Parkinson's Disease 4 5.00 Immunization 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Exercise partially reverses the effects of AMPK agonists and fasting on food intake through modulation of the AMPK-mTOR signaling pathway in the hypothalamus

Regulation (modulation) of AMPK in hypothalamus associated with agonist

1) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.07 Pain Relevance 0.05

Intracerebroventricular leptin reduces food intake by modulating AMPK-mTOR hypothalamic phosphorylation levels to a greater extent in exercised animals

Regulation (modulating) of AMPK associated with intracerebroventricular

2) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0.05

AMPK, ACC, p70S6K and 4EBP1 protein levels were not different between the groups (Figures 6c–f, lower panels).

Neg (not) Regulation (different) of AMPK

3) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.61 Pain Relevance 0

AMPK, ACC, p70S6K and 4EBP1 protein levels were not different between the groups (Figures 5b–e, lower panels).

Neg (not) Regulation (different) of AMPK

4) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.09 Pain Relevance 0

AMPK, ACC, p70S6K and 4EBP1 protein levels were not different between the groups (Figures 3b–e, lower panels).

Neg (not) Regulation (different) of AMPK

5) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0 Pain Relevance 0

Exercise partially reverses the effects of AMPK agonists and fasting on food intake through modulation of the AMPK-mTOR signaling pathway in the hypothalamus

Regulation (effects) of AMPK in hypothalamus associated with agonist

6) Confidence 0.26 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.08 Pain Relevance 0.05

Next, we investigated whether the increased sensitivity of the leptin action on food intake induced by exercise, could be due to the modulation of AMPK activity.

Regulation (modulation) of AMPK

7) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.29 Pain Relevance 0

Increased responsiveness of leptin action in the hypothalamus, through modulation of the AMPK-mediated pathway by exercise, could be pathophysiologically important in the prevention of obesity.

Regulation (modulation) of AMPK in hypothalamus associated with obesity

8) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.39 Pain Relevance 0

In conclusion, exercise improved the AMPK and mTOR responses to leptin administration and contributed to appetite-suppressive actions.

Regulation (responses) of AMPK

9) Confidence 0.18 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.32 Pain Relevance 0

Thus, although oxidative stress does activate AMPK (Choi et al., 2001; Hwang et al., 2005), the target for reactive oxygen species may not be AMPK itself but component(s) of the respiratory chain, leading to a secondary effect on AMPK via increases in AMP:ATP ratio.

Regulation (effect) of AMPK in respiratory associated with stress

10) Confidence 0.17 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.17 Pain Relevance 0

This study was designed to determine the effect of exercise intensity on the enzyme kinetics of ACC, malonyl-CoA levels, and AMPK activity in skeletal muscle.

Spec (determine) Regulation (effect) of AMPK in skeletal muscle

11) Confidence 0.16 Published 1997 Journal J. Appl. Physiol. Section Abstract Doc Link 9338417 Disease Relevance 0 Pain Relevance 0.09

Beyond STAT3 activation, we detected changes in the hypothalamic AMPK activity in rats after i.c.v. infusion of IL-6; we show that, IL-6 markedly decreased phospho-AMPK abundance (an index of activity) in the hypothalamus.

Regulation (changes) of AMPK in hypothalamus

12) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.18 Pain Relevance 0

As previously shown [43], exercise, per se, does not alter AMPK activity in the hypothalamus; however, we observed that the normal inhibition of AMPK phosphorylation and activity in the hypothalamus, induced by leptin administration, was improved in both lean and diet-induced obesity rats after acute protocol of exercise.

Neg (not) Regulation (alter) of AMPK in hypothalamus associated with obesity

13) Confidence 0.16 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2585815 Disease Relevance 0.30 Pain Relevance 0

AMPK is also regulated by cytokines involved in regulating whole-body energy balance (Kahn et al., 2005).

Regulation (regulated) of AMPK in body associated with cytokine

14) Confidence 0.09 Published 2010 Journal Cell Metabolism Section Body Doc Link PMC2935965 Disease Relevance 0.47 Pain Relevance 0.05

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