INT71757

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.73
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.11
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
Anatomy Link Frequency
nerve 1
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dorsal horn 3 99.36 Very High Very High Very High
dorsal root ganglion 9 99.12 Very High Very High Very High
Glutamate 7 95.24 Very High Very High Very High
Potency 26 94.52 High High
Action potential 3 90.96 High High
agonist 20 84.12 Quite High
Dorsal horn neuron 1 84.12 Quite High
Spinal cord 1 80.12 Quite High
qutenza 3 76.48 Quite High
Pain 6 71.68 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 9 99.12 Very High Very High Very High
Diabetes Mellitus 126 96.72 Very High Very High Very High
Increased Venous Pressure Under Development 22 95.40 Very High Very High Very High
Nociception 1 94.20 High High
Disease 2 84.08 Quite High
Obesity 2 64.60 Quite High
Stroke 8 60.00 Quite High
Aging 4 42.28 Quite Low
Pain 5 5.00 Very Low Very Low Very Low
Heart Rate Under Development 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we have used a DRG-dorsal horn co-culture system to show that P2X receptors are localized at presynaptic sites on DRG neurons; that activation of these receptors results in increased frequency of spontaneous glutamate release; and that activation of P2X receptors at or near presynaptic DRG nerve terminals elicits action potentials that cause evoked glutamate release.
Localization (localized) of P2X in nerve associated with action potential, dorsal root ganglion, glutamate and dorsal horn
1) Confidence 0.73 Published 1997 Journal Nature Section Abstract Doc Link 9338789 Disease Relevance 0.87 Pain Relevance 1.02
The co-localization of P2X1-4 receptors with flotillin clearly shows that these receptors are associated with lipid rafts; however, the extent of the association appears subtype-dependent.
Localization (localization) of P2X1
2) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
A similar distribution and co-localization with flotillin was seen for the P2X2 receptor consistent with its presence in lipid rafts.
Localization (localization) of P2X2 receptor
3) Confidence 0.70 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.04
Immunohistochemical analysis revealed that localization of P2Y2 and P2X1 receptors was consistent with previous findings in young healthy subjects, allowing us to conclude that the reduction in vasodilatatory potency is not due to changes in receptor distribution.
Localization (localization) of P2X1 associated with potency
4) Confidence 0.14 Published 2010 Journal Diabetes Section Body Doc Link PMC2797920 Disease Relevance 0.50 Pain Relevance 0.05
We determined localization of P2Y2 and P2X1 receptors and measured levels of mRNA of P2Y2 receptors to investigate potential downregulation.
Spec (determined) Localization (localization) of P2X1
5) Confidence 0.14 Published 2010 Journal Diabetes Section Body Doc Link PMC2797920 Disease Relevance 0.73 Pain Relevance 0.03
We have demonstrated previously that the P2X receptor from D. discoideum is localized inside the cell, where it controls organelle function (4).
Localization (localized) of P2X receptor
6) Confidence 0.11 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2397467 Disease Relevance 0 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox