INT71759

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 19
Disease Relevance 3.53
Pain Relevance 4.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
Anatomy Link Frequency
tube 1
nerve 1
BFA 1
DRG 1
leaflet 1
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 20 99.62 Very High Very High Very High
antagonist 30 99.50 Very High Very High Very High
dorsal root ganglion 27 99.44 Very High Very High Very High
Action potential 9 98.28 Very High Very High Very High
cytokine 69 98.00 Very High Very High Very High
Pain 24 97.32 Very High Very High Very High
agonist 172 96.56 Very High Very High Very High
Dorsal horn 9 95.88 Very High Very High Very High
imagery 12 92.64 High High
Inflammatory response 3 91.80 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 27 99.44 Very High Very High Very High
Pain 18 95.80 Very High Very High Very High
Injury 2 93.60 High High
Nociception 6 92.16 High High
INFLAMMATION 20 91.44 High High
Hyperalgesia 1 82.08 Quite High
Neuropathic Pain 3 80.72 Quite High
Contact Dermatitis 1 80.28 Quite High
Nervous System Injury 1 66.80 Quite High
Shock 13 25.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus activation of P2X receptors at DRG central terminals can modify sensory signal throughput, and might even initiate sensory signals at central synapses without direct peripheral input.
Positive_regulation (activation) of P2X in DRG associated with dorsal root ganglion
1) Confidence 0.67 Published 1997 Journal Nature Section Abstract Doc Link 9338789 Disease Relevance 0.80 Pain Relevance 1.04
Here we have used a DRG-dorsal horn co-culture system to show that P2X receptors are localized at presynaptic sites on DRG neurons; that activation of these receptors results in increased frequency of spontaneous glutamate release; and that activation of P2X receptors at or near presynaptic DRG nerve terminals elicits action potentials that cause evoked glutamate release.
Positive_regulation (activation) of P2X in nerve associated with action potential, dorsal root ganglion, glutamate and dorsal horn
2) Confidence 0.67 Published 1997 Journal Nature Section Abstract Doc Link 9338789 Disease Relevance 0.84 Pain Relevance 1.06
50% increase in current amplitude for the P2X2 receptor (Fig. 3b).
Positive_regulation (increase) of P2X2 receptor
3) Confidence 0.65 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.03
Rapid drug application from a U-tube perfusion system caused cellular movement incompatible with FRAP measurements, thus for studies of P2X1 receptor activation ?
Positive_regulation (activation) of P2X1 in tube
4) Confidence 0.48 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.08
P2X1 receptor responses can be potentiated by stimulation of G?
Positive_regulation (potentiated) of P2X1
5) Confidence 0.48 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.03
Taken together, these results suggest that cholesterol depletion has an effect on P2X1 receptor channel gating/activation.
Positive_regulation (activation) of P2X1 receptor
6) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.08
Whether cholesterol acts directly to stabilize the conformation of the P2X1 receptor or association with lipid rafts favors interaction with inner leaflet lipids that regulate the channel remains to be determined.


Positive_regulation (stabilize) of P2X1 receptor in leaflet
7) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.11
This demonstrates that in contrast to some G-protein-coupled receptors, the activation of P2X1-4 ligand-gated ion channel receptors does not result in movement out of the lipid rafts.


Positive_regulation (activation) of P2X1
8) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.04
To determine whether the lipid rafts play a regulatory role on the P2X1-4 receptor function, we tested the effects of disrupting the lipid rafts either by using filipin (10 ?
Spec (whether) Positive_regulation (role) of P2X1
9) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
Replacement of either of the clusters in P2X1 with the P2X2 receptor sequence produced channels that were either insensitive to cholesterol depletion P2X1-mut27–29 or actually potentiated P2X1-mut20–23 (Fig. 5f).
Positive_regulation (potentiated) of P2X1
10) Confidence 0.47 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses.
Positive_regulation (Activation) of P2X in synapses associated with glutamate
11) Confidence 0.45 Published 1997 Journal Nature Section Title Doc Link 9338789 Disease Relevance 0.76 Pain Relevance 0.92
Activation of the P2X1 receptor with ?
Positive_regulation (Activation) of P2X1
12) Confidence 0.44 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0
On the other hand, as a positive feedback, trafficking events can also be regulated by activation of P2X1 receptor.
Positive_regulation (activation) of P2X1
13) Confidence 0.44 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.13
Effects of P2X1 receptor activation on mobility
Positive_regulation (activation) of P2X1
14) Confidence 0.44 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.08
These results suggest that in addition to the BFA sensitive constitutive component there is a calcium-sensitive (BFA-insensitive) pathway triggered by P2X1 receptor activation that contributes to receptor trafficking.
Positive_regulation (activation) of P2X1 in BFA
15) Confidence 0.44 Published 2010 Journal Journal of Neurochemistry Section Body Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.08
Activation of P2X1 and P2X3 receptors results in desensitization, and ?
Positive_regulation (Activation) of P2X1
16) Confidence 0.43 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.05
With the exception of the P2X7 receptor, functional responses attendant to activation of P2X receptor family members are not generally associated with cytokine modulation.
Positive_regulation (activation) of P2X receptor associated with cytokine
17) Confidence 0.15 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096759 Disease Relevance 0.35 Pain Relevance 0.47
The P2X receptor in green algae contains many of the residues considered to be important for P2X receptor function, such as conserved lysine residues at positions equivalent to Lys69 and Lys308 of rat P2X2.
Positive_regulation (important) of P2X receptor
18) Confidence 0.06 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2397467 Disease Relevance 0 Pain Relevance 0
Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and P2X(7), and P2Y (e.g., P2Y(2)) receptors, can modulate pain.
Positive_regulation (activation) of P2X receptor associated with pain and antagonist
19) Confidence 0.02 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18042830 Disease Relevance 0.77 Pain Relevance 0.69

General Comments

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