INT71764

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 26
Disease Relevance 12.31
Pain Relevance 5.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Mri1) nucleus (Mri1) cytoplasm (Mri1)
Anatomy Link Frequency
brain 6
ligaments 1
macrophages 1
blood 1
upper 1
Mri1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 690 100.00 Very High Very High Very High
Glutamate 2 99.84 Very High Very High Very High
fibrosis 17 97.72 Very High Very High Very High
amygdala 93 97.48 Very High Very High Very High
isoflurane 13 96.24 Very High Very High Very High
Pain 96 96.08 Very High Very High Very High
positron emission tomography 80 95.68 Very High Very High Very High
anesthesia 39 95.52 Very High Very High Very High
Central nervous system 72 93.56 High High
Inflammation 52 92.24 High High
Disease Link Frequency Relevance Heat
Necrosis 48 99.90 Very High Very High Very High
Glioma 117 99.56 Very High Very High Very High
Neck Injuries 6 99.52 Very High Very High Very High
Hypercapnia 5 99.36 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

120 99.04 Very High Very High Very High
Disease 103 98.76 Very High Very High Very High
Cancer 567 98.44 Very High Very High Very High
Apoptosis 84 98.36 Very High Very High Very High
Renal Disease 4 98.36 Very High Very High Very High
Radiation Sickness 84 98.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ultra-fast and accurate assessment of cardiac function in rats using accelerated MRI at 9.4 Tesla.
Positive_regulation (accelerated) of MRI
1) Confidence 0.44 Published 2008 Journal Magn Reson Med Section Title Doc Link 18306411 Disease Relevance 0 Pain Relevance 0.26
Hypercapnia produced significantly greater increases in MRI signal intensity in fully conscious animals (6.7-13.3% changes) as when anesthetized with 1% isoflurane (3.2-4.9% changes).
Positive_regulation (increases) of MRI associated with hypercapnia and isoflurane
2) Confidence 0.41 Published 2003 Journal Magn Reson Imaging Section Abstract Doc Link 14684202 Disease Relevance 0.19 Pain Relevance 0.21
Both cortical and subcortical brain regions showed a robust, dose- dependent increase in MRI signal intensity with hypercapnic challenge while the animals were conscious but little or no change when anesthetized.
Positive_regulation (increase) of MRI in brain
3) Confidence 0.41 Published 2003 Journal Magn Reson Imaging Section Abstract Doc Link 14684202 Disease Relevance 0.18 Pain Relevance 0.20
Due to the slow clearance of Mn2+ from the stimulated region of the brain, MRI enhancement could also be detected after stimulation that occurred on awake, behaving rats outside the magnet.
Positive_regulation (enhancement) of MRI in brain
4) Confidence 0.30 Published 1997 Journal Magn Reson Med Section Abstract Doc Link 9339438 Disease Relevance 0 Pain Relevance 0.26
Activation of the brain with glutamate led to increase in MRI signal intensity in the brain to 238 +/- 23% of the original.
Positive_regulation (increase) of MRI in brain associated with glutamate
5) Confidence 0.30 Published 1997 Journal Magn Reson Med Section Abstract Doc Link 9339438 Disease Relevance 0 Pain Relevance 0.27
In conclusion, the present study provides evidence of increased brain activation, measured as increased MRI signal, in response to CRD in rats, following exposure of the amygdala to elevated levels of CORT for 7 days.
Positive_regulation (increased) of MRI in brain associated with amygdala
6) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2797306 Disease Relevance 0 Pain Relevance 0.24
All patients underwent MRI of their upper neck ligaments.
Positive_regulation (underwent) of MRI in ligaments associated with imagery
7) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989946 Disease Relevance 0.68 Pain Relevance 0.36
Within 13 days after a car accident, 114 consecutive acute WAD1-2 patients without prior neck injury or prior neck problems underwent upper neck high-resolution proton-weighted MRI.
Positive_regulation (underwent) of MRI in upper associated with neck injuries and imagery
8) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2989946 Disease Relevance 0.41 Pain Relevance 0.24
We hardly missed relevant high-signal changes, since every patient underwent dedicated MRI within 13 days (86.5% within 7 days) after the accident.
Positive_regulation (underwent) of MRI associated with imagery
9) Confidence 0.17 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989946 Disease Relevance 0.60 Pain Relevance 0.38
This stems from the fact that in psMRI, deoxyHb accumulation is coupled to oxygen consumption by photon-capture of the sensitizer and diffusion-limited dissociation of oxyHb.
Positive_regulation (accumulation) of psMRI in stems
10) Confidence 0.17 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2077809 Disease Relevance 0.06 Pain Relevance 0.14
The 24 hours post Taxotere treated tumors showed unchanged IR MRI signal intensities at histology matched necrosis but increased IR MRI signal intensities at histology matched apoptosis showed as yellow arrows on panels A and B (see pre Taxotere and post taxotere images) following the Taxotere drug administration as shown in Figure 6.
Positive_regulation (increased) of MRI associated with necrosis, cancer and apoptosis
11) Confidence 0.17 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC1208921 Disease Relevance 1.26 Pain Relevance 0
As shown in Fig. 3, the increase in the paraclinical (CSF and blood bacterial counts, CSF WBC) and MRI data (ventricle-brain ratio (VBR), Apparent Diffusion Coefficient (ADC) and dynamic MRI (dMRI)) was non-linear as the disease progressed with time.
Positive_regulation (increase) of MRI in brain associated with disease and imagery
12) Confidence 0.16 Published 2008 Journal BMC Med Imaging Section Body Doc Link PMC2253532 Disease Relevance 1.32 Pain Relevance 0.24
As shown in Fig. 3, the increase in the paraclinical (CSF and blood bacterial counts, CSF WBC) and MRI data (ventricle-brain ratio (VBR), Apparent Diffusion Coefficient (ADC) and dynamic MRI (dMRI)) was non-linear as the disease progressed with time.
Positive_regulation (increase) of MRI in brain associated with disease and imagery
13) Confidence 0.16 Published 2008 Journal BMC Med Imaging Section Body Doc Link PMC2253532 Disease Relevance 1.15 Pain Relevance 0.21
BKL assisted in vivo MRI experiments and processed the MRI data.
Positive_regulation (experiments) of MRI associated with imagery
14) Confidence 0.15 Published 2009 Journal J Transl Med Section Body Doc Link PMC2774309 Disease Relevance 0.40 Pain Relevance 0.48
2+-enhanced MRI
Positive_regulation (enhanced) of MRI associated with imagery
15) Confidence 0.12 Published 2007 Journal Frontiers in Neuroinformatics Section Body Doc Link PMC2525992 Disease Relevance 0.15 Pain Relevance 0.15
Additionally, CORT implants produced significant positive bilateral increases in MRI signal in response to CRD in specific nuclei known as integration sites important in anxiety and pain perception.


Positive_regulation (increases) of MRI associated with pain and anxiety disorder
16) Confidence 0.12 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2797306 Disease Relevance 0.32 Pain Relevance 0.38
Gadolinium (Gd), with its 7 unpaired electrons in 4f orbitals that provide a very large magnetic moment, is proven to be among the best agents for contrast enhanced MRI.
Positive_regulation (enhanced) of MRI
17) Confidence 0.07 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948015 Disease Relevance 0.15 Pain Relevance 0.15
The first class of probes provides positive contrast in MR images and is targeted to macrophages by using the SRA ligand maleylated bovine serum albumin (Mal-BSA) as the macromolecule carrier for conjugation of imaging probes, while the second provides negative MRI contrast and is nonspecifically taken up by macrophages.
Positive_regulation (negative) of MRI in macrophages associated with imagery
18) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952595 Disease Relevance 0.16 Pain Relevance 0.21
To palliate this lack of dynamic studies in the BBBD process, we have designed a methodology allowing osmotic BBBD to be conducted directly in the animal MRI gantry, thus permitting the acquisition of images dynamically before, during and after the procedure.
Positive_regulation (conducted) of MRI
19) Confidence 0.05 Published 2008 Journal AAPS J Section Body Doc Link PMC2751463 Disease Relevance 0 Pain Relevance 0.08
Fig. 7An axial T1 Gd-DTPA enhanced MRI immediately after BBBD is analyzed using an exposition map translating the area under the curve (AUC).
Positive_regulation (enhanced) of MRI
20) Confidence 0.05 Published 2008 Journal AAPS J Section Body Doc Link PMC2751463 Disease Relevance 0 Pain Relevance 0.05

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