INT71766

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 24.66
Pain Relevance 10.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
spleen 3
liver 2
brain 2
connective tissue 2
lymph nodes 1
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 540 100.00 Very High Very High Very High
cytokine 536 100.00 Very High Very High Very High
chemokine 83 100.00 Very High Very High Very High
antagonist 21 100.00 Very High Very High Very High
metalloproteinase 2 99.60 Very High Very High Very High
Sciatic nerve 6 99.36 Very High Very High Very High
Eae 10 98.88 Very High Very High Very High
cINOD 19 98.36 Very High Very High Very High
Inflammatory stimuli 18 97.60 Very High Very High Very High
Paracetamol 24 95.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 634 100.00 Very High Very High Very High
Cancer 253 100.00 Very High Very High Very High
Necrosis 47 100.00 Very High Very High Very High
Lewis Lung Carcinoma 408 99.68 Very High Very High Very High
Targeted Disruption 99 99.68 Very High Very High Very High
Sepsis 31 99.14 Very High Very High Very High
Injury 93 98.88 Very High Very High Very High
Infection 136 98.60 Very High Very High Very High
Cerebral Malaria 124 96.76 Very High Very High Very High
Body Weight 52 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, IL-10 mRNA expression of M phi s was rapidly induced after MAC-infection and the maximum level of the mRNA expression was achieved at 2 hr.
Transcription (expression) of IL-10 associated with infection
1) Confidence 0.69 Published 1997 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 9339628 Disease Relevance 0.61 Pain Relevance 0.73
Instead, Kupffer cell depletion by liposome/clodronate led to significant decreases in the levels of hepatic mRNA expression of several hepato-regulatory cytokines and mediators, including IL-6, IL-10, IL-18 binding protein and complement 1q, suggesting that Kupffer cells are a significant source for production of these mediators in this model.
Transcription (expression) of IL-10 in Kupffer cell associated with cytokine
2) Confidence 0.65 Published 2002 Journal Chem. Res. Toxicol. Section Abstract Doc Link 12482232 Disease Relevance 0.36 Pain Relevance 0.58
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Transcription (Expression) of interleukin-10 in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
3) Confidence 0.61 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.16 Pain Relevance 0.70
However, mice receiving 25×106 cells showed a tendency to increased expression of IL-10 mRNA.
Transcription (expression) of IL-10
4) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.07 Pain Relevance 0.42
Although, there were no statistical differences in IL-2 mRNA and IL-10 m RNA expressions between G93A mice treated with different cell doses and control animals (Media, CsA, hTgn, C57), mice receiving 25×106 MNC hUCB cells tended towards decreased IL-2 mRNA and increased IL-10 mRNA expressions in the spleen.
Transcription (expressions) of IL-10 in spleen
5) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.20
Although, there were no statistical differences in IL-2 mRNA and IL-10 m RNA expressions between G93A mice treated with different cell doses and control animals (Media, CsA, hTgn, C57), mice receiving 25×106 MNC hUCB cells tended towards decreased IL-2 mRNA and increased IL-10 mRNA expressions in the spleen.
Transcription (expressions) of IL-10 in spleen
6) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.13
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Transcription (Expression) of IL-10 in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
7) Confidence 0.53 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.16 Pain Relevance 0.70
Thereafter, IL-10 mRNA expression ceased rapidly and returned to normal by 24 hr.
Transcription (expression) of IL-10
8) Confidence 0.52 Published 1997 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 9339628 Disease Relevance 0.54 Pain Relevance 0.72
In the liver, higher levels of IFN-gamma, interleukin (IL)-4, and IL-10 mRNAs were detected and were associated with bacterial translocation, inflammation, and apoptosis.
Transcription (detected) of IL-10 in liver
9) Confidence 0.52 Published 2003 Journal Gastroenterology Section Body Doc Link 12949725 Disease Relevance 0.07 Pain Relevance 0
At that time, HFD-fed mice had increased serum levels and fat mRNA expression of the immune suppressing cytokines interleukin-1 receptor antagonist (IL-1Ra) and IL-10 compared with LFD-fed mice.
Transcription (expression) of IL-10 in fat associated with antagonist and cytokine
10) Confidence 0.50 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2765728 Disease Relevance 0.72 Pain Relevance 0.15
Additionally, although mice treated with 25×106 cells had high variability in IL-2 and IL-10 mRNA expressions in the spleen, they markedly decreased and increased these cytokines respectively.
Transcription (expressions) of IL-10 in spleen associated with cytokine
11) Confidence 0.43 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.06 Pain Relevance 0.45
To investigate the very early temporal pattern of cytokine regulation we studied 140 mice of C57Bl/6J background after chronic constriction injury (CCI) of the right sciatic nerve and measured the relative mRNA expression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNF) and interleukin-1beta (IL-1beta) and of the anti-inflammatory cytokines IL-4 and IL-10 with quantitative real-time polymerase chain reaction (qRT-PCR).
Transcription (expression) of IL-10 in sciatic nerve associated with necrosis, inflammation, cancer, eae, injury, sciatic nerve and cytokine
12) Confidence 0.38 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.15 Pain Relevance 0.76
levels and significantly decreased IL-10 levels in A2A knockout mice.


Transcription (levels) of IL-10 associated with targeted disruption
13) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.44 Pain Relevance 0.56
Furthermore, the RAE had little effects on IL-10 mRNA expression in lung cells (Table 3).
Transcription (expression) of IL-10 in lung
14) Confidence 0.32 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.21 Pain Relevance 0.08
Thus, it is important to note that while the EX subjects in the current study tended to experience an increase in IL-10 mRNA expression and had increased expression of the MC3R, they did not experience significant alterations in body weight or composition.
Transcription (expression) of IL-10 in body associated with body weight
15) Confidence 0.32 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.06 Pain Relevance 0.48
Following LPS stimulation, apoE4-macrophages showed higher and lower concentrations of tumour necrosis factor alpha (pro-inflammatory) and interleukin 10 (anti-inflammatory), respectively, both at mRNA and protein levels.
Transcription (mRNA) of interleukin 10 in macrophages associated with necrosis, inflammation and cancer
16) Confidence 0.32 Published 2007 Journal Biochemical and Biophysical Research Communications Section Abstract Doc Link PMC2096715 Disease Relevance 1.00 Pain Relevance 0.23
We found that B1R gene deletion or antagonism resulted in higher expression of the anti-inflammatory GATA-3, IL-4 and IL-10 and lower transcription of the pro-inflammatory T-bet and IL-1?.
Transcription (transcription) of IL-10 associated with inflammation
17) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2516176 Disease Relevance 1.32 Pain Relevance 0.33
In the present study, we observed a similar increase of IL-10 mRNA levels as well as TGF?
Transcription (levels) of IL-10
18) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.07 Pain Relevance 0.28
As previously reported [37], TNBS also strongly induced mRNA expression for IL-10, which could not be inhibited by potent anti-inflammatory drugs.
Transcription (expression) of IL-10 associated with inflammation and cinod
19) Confidence 0.31 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.14 Pain Relevance 0.29
We found an ipsilateral upregulation of TNF, IL-1beta and IL-10 mRNA levels as early as one hour after CCI.
Transcription (levels) of IL-10 associated with eae
20) Confidence 0.30 Published 2007 Journal Brain Behav. Immun. Section Abstract Doc Link 17204395 Disease Relevance 1.06 Pain Relevance 0.74

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