INT71767

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Context Info
Confidence 0.67
First Reported 1997
Last Reported 2011
Negated 3
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.55
Pain Relevance 4.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
spleen 6
connective tissue 4
liver 2
body 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 2 100.00 Very High Very High Very High
Paracetamol 16 99.04 Very High Very High Very High
cINOD 9 98.16 Very High Very High Very High
cytokine 175 94.80 High High
Inflammation 146 91.76 High High
qutenza 3 91.76 High High
Neuropeptide 2 88.72 High High
Calcitonin gene-related peptide 1 86.72 High High
Inflammatory mediators 6 86.52 High High
Glutamate 4 82.88 Quite High
Disease Link Frequency Relevance Heat
Necrosis 20 100.00 Very High Very High Very High
Cancer 18 100.00 Very High Very High Very High
Infection 6 99.56 Very High Very High Very High
INFLAMMATION 170 97.92 Very High Very High Very High
Body Weight 29 96.24 Very High Very High Very High
Targeted Disruption 17 94.08 High High
Multiple Sclerosis 3 92.56 High High
Sprains And Strains 33 90.24 High High
Injury 7 87.60 High High
Inflammatory Bowel Disease 15 81.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secondly, IL-10 mRNA expression of M phi s was rapidly induced after MAC-infection and the maximum level of the mRNA expression was achieved at 2 hr.
Positive_regulation (induced) of Transcription (expression) of IL-10 associated with infection
1) Confidence 0.67 Published 1997 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 9339628 Disease Relevance 0.61 Pain Relevance 0.73
However, mice receiving 25×106 cells showed a tendency to increased expression of IL-10 mRNA.
Positive_regulation (increased) of Transcription (expression) of IL-10
2) Confidence 0.56 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.08 Pain Relevance 0.42
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Positive_regulation (increased) of Transcription (Expression) of interleukin-10 in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
3) Confidence 0.45 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.23 Pain Relevance 0.78
Although, there were no statistical differences in IL-2 mRNA and IL-10 m RNA expressions between G93A mice treated with different cell doses and control animals (Media, CsA, hTgn, C57), mice receiving 25×106 MNC hUCB cells tended towards decreased IL-2 mRNA and increased IL-10 mRNA expressions in the spleen.
Neg (no) Positive_regulation (differences) of Transcription (expressions) of IL-10 in spleen
4) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.23
Although, there were no statistical differences in IL-2 mRNA and IL-10 m RNA expressions between G93A mice treated with different cell doses and control animals (Media, CsA, hTgn, C57), mice receiving 25×106 MNC hUCB cells tended towards decreased IL-2 mRNA and increased IL-10 mRNA expressions in the spleen.
Neg (no) Positive_regulation (increased) of Transcription (expressions) of IL-10 in spleen
5) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.20
Although, there were no statistical differences in IL-2 mRNA and IL-10 m RNA expressions between G93A mice treated with different cell doses and control animals (Media, CsA, hTgn, C57), mice receiving 25×106 MNC hUCB cells tended towards decreased IL-2 mRNA and increased IL-10 mRNA expressions in the spleen.
Neg (no) Positive_regulation (differences) of Transcription (expressions) of IL-10 in spleen
6) Confidence 0.41 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0 Pain Relevance 0.16
Expression of mRNA for tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), matrix metalloproteinase-9, and connective tissue growth factor (CTGF) also increased in the liver following acetaminophen treatment of wild-type mice.
Positive_regulation (increased) of Transcription (Expression) of IL-10 in connective tissue associated with necrosis, paracetamol, cancer and metalloproteinase
7) Confidence 0.39 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.23 Pain Relevance 0.78
Thus, it is important to note that while the EX subjects in the current study tended to experience an increase in IL-10 mRNA expression and had increased expression of the MC3R, they did not experience significant alterations in body weight or composition.
Positive_regulation (increase) of Transcription (expression) of IL-10 in body associated with body weight
8) Confidence 0.31 Published 2011 Journal Journal of Aging Research Section Body Doc Link PMC3022199 Disease Relevance 1.07 Pain Relevance 0.48
In the present study, we observed a similar increase of IL-10 mRNA levels as well as TGF?
Positive_regulation (increase) of Transcription (levels) of IL-10
9) Confidence 0.30 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819555 Disease Relevance 1.08 Pain Relevance 0.29
It also inhibited TNF-alpha and IL-1beta mRNA expression, and increased IL-10 mRNA expression in LPS-treated murine liver.
Positive_regulation (increased) of Transcription (expression) of IL-10 in liver
10) Confidence 0.21 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19878665 Disease Relevance 0.26 Pain Relevance 0.60

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