INT71768

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 6
Speculated 7
Reported most in Abstract
Documents 27
Total Number 33
Disease Relevance 19.17
Pain Relevance 10.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
peritoneal macrophages 6
lung 4
macrophages 2
alternatively activated macrophages 2
B cells 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 410 100.00 Very High Very High Very High
Inflammation 326 100.00 Very High Very High Very High
cINOD 22 100.00 Very High Very High Very High
Pain 11 100.00 Very High Very High Very High
Opioid 6 100.00 Very High Very High Very High
rheumatoid arthritis 18 99.30 Very High Very High Very High
Morphine 12 98.92 Very High Very High Very High
Analgesic 4 98.12 Very High Very High Very High
agonist 19 97.96 Very High Very High Very High
opioid receptor 2 97.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 345 100.00 Very High Very High Very High
Targeted Disruption 94 99.88 Very High Very High Very High
Disease 168 99.84 Very High Very High Very High
Infection 263 99.76 Very High Very High Very High
Necrosis 98 99.72 Very High Very High Very High
Pain 6 99.52 Very High Very High Very High
Rheumatoid Arthritis 27 99.30 Very High Very High Very High
Epstein-barr Virus 72 99.06 Very High Very High Very High
Pulmonary Fibrosis 98 98.92 Very High Very High Very High
Cancer 192 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our aim was to investigate the role of adrenoceptors in the modulation of in vivo interleukin-10 (IL-10) production in lipopolysaccharide (LPS)-treated mice.
Spec (investigate) Regulation (role) of Gene_expression (production) of interleukin-10
1) Confidence 0.62 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.20
Opposite role of alpha2- and beta-adrenoceptors in the modulation of interleukin-10 production in endotoxaemic mice.
Regulation (modulation) of Gene_expression (production) of interleukin-10
2) Confidence 0.62 Published 2000 Journal Neuroreport Section Title Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.23
Our results provide the first in vivo evidence that, in addition to beta-adrenoceptors; alpha-adrenoceptors play also a very important role in the regulation of IL-10 production under endotoxaemic conditions.
Regulation (regulation) of Gene_expression (production) of IL-10
3) Confidence 0.62 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.26
In this study, we examined the effects of various anti-inflammatory drugs including glucocorticoids and non-steroidal anti-inflammatory drugs (NSAID) on in-vitro IL-10 production of murine peritoneal macrophages (M phi s) infected with MAC organisms.
Spec (examined) Regulation (effects) of Gene_expression (production) of IL-10 in peritoneal macrophages associated with inflammation and cinod
4) Confidence 0.60 Published 1997 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 9339628 Disease Relevance 0.67 Pain Relevance 0.65
[Effects of various steroidal and non-steroidal anti-inflammatory drugs on in-vitro IL-10 production of murine peritoneal macrophages infected with Mycobacterium avium complex].
Regulation (Effects) of Gene_expression (production) of IL-10 in peritoneal macrophages associated with inflammation and cinod
5) Confidence 0.60 Published 1997 Journal Kansensh?gaku Zasshi Section Title Doc Link 9339628 Disease Relevance 0.56 Pain Relevance 0.50
We evaluated the ability of the specific micro opioid receptor agonist DAMGO, the kappa-specific agonist U-50488 in vitro, and exogenous opioid morphine administered in vivo both acutely and chronically to modulate IL-12 and IL-10 production by murine peritoneal macrophages.
Regulation (modulate) of Gene_expression (production) of IL-10 in peritoneal macrophages associated with agonist, opioid receptor, opioid and morphine
6) Confidence 0.59 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 12794053 Disease Relevance 0 Pain Relevance 0.65
On the other hand, IL-6 inhibition without the unwanted effects on TNF and IL-10 production shown by R-isomers could be correlated to the analgesic effect reported for R-2-arylpropionic acids.
Neg (without) Regulation (effects) of Gene_expression (production) of IL-10 associated with analgesic
7) Confidence 0.55 Published 2000 Journal Eur. Cytokine Netw. Section Abstract Doc Link 10903797 Disease Relevance 0.32 Pain Relevance 0.37
Our aim was to investigate the role of adrenoceptors in the modulation of in vivo interleukin-10 (IL-10) production in lipopolysaccharide (LPS)-treated mice.
Regulation (modulation) of Gene_expression (production) of IL-10
8) Confidence 0.45 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.20
These results provide strong evidence that M2 induction of IL-10 secretion, either from latently infected B cells or some other latency reservoir (e.g., infected macrophages or dendritic cells), contributes significantly to the serum levels of IL-10 observed during MHV68 infection following either intranasal or intraperitoneal virus inoculation.


Regulation (contributes) of Gene_expression (levels) of IL-10 in B cells associated with infection
9) Confidence 0.44 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.33 Pain Relevance 0.03
The IL-10 response in serum of GF mice was responsible for the enhanced response of Kupffer cells to LPS (Fig. 2).
Regulation (responsible) of Gene_expression (response) of IL-10 in Kupffer cells
10) Confidence 0.44 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.11 Pain Relevance 0.20
These results suggest that high levels of serum IL-10 in GF mice may be partly responsible for the lower in vivo responsiveness of TNF-?
Spec (may) Regulation (responsible) of Gene_expression (levels) of IL-10
11) Confidence 0.44 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.08 Pain Relevance 0.08
Effects of in vitro and in vivo opioids on the production of IL-12 and IL-10 by murine macrophages.
Regulation (Effects) of Gene_expression (production) of IL-10 in macrophages associated with pain and opioid
12) Confidence 0.43 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Title Doc Link 12794053 Disease Relevance 0 Pain Relevance 1.14
On the other hand, R-isomers did not affect TNF and IL-10 production even at cyclooxygenase-blocking concentration, while they reduced IL-6 production to the same levels as S-isomers.
Neg (not) Regulation (affect) of Gene_expression (production) of IL-10
13) Confidence 0.40 Published 2000 Journal Eur. Cytokine Netw. Section Abstract Doc Link 10903797 Disease Relevance 0.57 Pain Relevance 0.48
No significant effect of the anti-inflammatory treatments was observed on lung inflammatory parameters as well as cytokine production (IL-10, IL-4, IL-13 and IFN-?)
Neg (No) Regulation (effect) of Gene_expression (production) of IL-10 in lung associated with inflammation and cytokine
14) Confidence 0.38 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.50 Pain Relevance 0.88
Our KLH experiments indicate that Bv8 affects a number of temporal steps in immune activation: the in vivo experiments showed that it significantly modulates IL-4 and IL-10 production regardless of whether it is given at the time of KLH immunisation or four hours before in vitro KLH restimulation.
Spec (whether) Regulation (modulates) of Gene_expression (production) of IL-10 associated with immunization
15) Confidence 0.33 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.16 Pain Relevance 0.20
After HIFU-treatment, however, tumor cells became effective in inducing IL-12p70 production while their effects on IL-10 production markedly reduced.
Regulation (effects) of Gene_expression (production) of IL-10 associated with cancer
16) Confidence 0.27 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.71 Pain Relevance 0.04
Our aim was to investigate the role of adrenoceptors in the modulation of in vivo interleukin-10 (IL-10) production in lipopolysaccharide (LPS)-treated mice.
Regulation (modulation) of Gene_expression (production) of interleukin-10
17) Confidence 0.27 Published 2000 Journal Neuroreport Section Abstract Doc Link 11095519 Disease Relevance 0 Pain Relevance 0.20
The latter was dependent on IL-10 expression as demonstrated by the failure of IL10?
Regulation (dependent) of Gene_expression (expression) of IL-10
18) Confidence 0.27 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2270344 Disease Relevance 0.50 Pain Relevance 0
These facts suggest that since oral administration of LPS or bacterial flora might alter the IL-10 production, serum IL-10 production could be enhanced in GF mice.
Spec (might) Regulation (alter) of Gene_expression (production) of IL-10
19) Confidence 0.26 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0 Pain Relevance 0.13
We constructed transgenic mice expressing murine IL-10 under the control of the human VMD2 gene promoter in B6CBAF2/J founder mice [3].
Regulation (under) of Gene_expression (expressing) of IL-10 associated with targeted disruption
20) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.72 Pain Relevance 0.20

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