INT71769

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 40
Total Number 40
Disease Relevance 22.53
Pain Relevance 10.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
macrophage 9
T cells 6
blood 3
monocyte 3
spinal cord 2
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 819 99.92 Very High Very High Very High
Inflammation 718 98.72 Very High Very High Very High
Analgesic 6 98.12 Very High Very High Very High
Pain 56 97.60 Very High Very High Very High
methotrexate 50 97.26 Very High Very High Very High
fibrosis 65 96.72 Very High Very High Very High
Inflammatory response 68 96.36 Very High Very High Very High
Spinal cord 37 95.80 Very High Very High Very High
Paracetamol 8 95.16 Very High Very High Very High
Demyelination 19 89.60 High High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 55 99.96 Very High Very High Very High
Targeted Disruption 159 99.68 Very High Very High Very High
Sprains And Strains 154 99.40 Very High Very High Very High
Pulmonary Fibrosis 50 99.16 Very High Very High Very High
Toxicity 15 98.96 Very High Very High Very High
INFLAMMATION 825 98.72 Very High Very High Very High
Infection 383 98.52 Very High Very High Very High
Disease Progression 10 98.12 Very High Very High Very High
Rheumatoid Arthritis 22 97.80 Very High Very High Very High
Pain 54 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We next examined whether loss of M2 expression and the concomitant reduction in IL-10 expression might alter the CD8 T cell response to MHV68 since IL-10 is known to suppress T cell responses [18].
Negative_regulation (reduction) of Gene_expression (expression) of IL-10 in T cell
1) Confidence 0.57 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 0.41 Pain Relevance 0
On the other hand, oral administration of LPS in drinking water for germfree mice caused a decrease in IL-10 production in serum compared to GF control (Fig. 1).
Negative_regulation (decrease) of Gene_expression (production) of IL-10
2) Confidence 0.57 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0 Pain Relevance 0.10
First, the IL-10 production into M phi culture fluids was temporarily increased around days 1 to 3, thereafter gradually declined, and returned to normal by day 14.
Negative_regulation (declined) of Gene_expression (production) of IL-10
3) Confidence 0.57 Published 1997 Journal Kansensh?gaku Zasshi Section Abstract Doc Link 9339628 Disease Relevance 0.68 Pain Relevance 0.75
In addition, up-regulation of TNF production by S-isomers is associated with inhibition of interleukin-10 (IL-10) production.
Negative_regulation (inhibition) of Gene_expression (production) of IL-10
4) Confidence 0.52 Published 2000 Journal Eur. Cytokine Netw. Section Abstract Doc Link 10903797 Disease Relevance 0.54 Pain Relevance 0.42
In contrast, IL-10 expression was reduced.
Negative_regulation (reduced) of Gene_expression (expression) of IL-10
5) Confidence 0.52 Published 2002 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 12392966 Disease Relevance 1.00 Pain Relevance 0.76
Therefore, the absence of IL-10 expression accelerates the kinetics of lesion expansion, the onset of pain behaviors, and the peripheral immune response to spinal cord injury.
Negative_regulation (absence) of Gene_expression (expression) of IL-10 in spinal cord associated with pain and spinal cord
6) Confidence 0.43 Published 2004 Journal Neuroscience Section Abstract Doc Link 15026134 Disease Relevance 1.22 Pain Relevance 0.63
We first attempted to block IL-10 protein expression with blocking antibodies to IL-10.
Negative_regulation (block) of Gene_expression (expression) of IL-10 protein
7) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2743195 Disease Relevance 1.06 Pain Relevance 0.25
On the other hand, IL-6 inhibition without the unwanted effects on TNF and IL-10 production shown by R-isomers could be correlated to the analgesic effect reported for R-2-arylpropionic acids.
Negative_regulation (inhibition) of Gene_expression (production) of IL-10 associated with analgesic
8) Confidence 0.38 Published 2000 Journal Eur. Cytokine Netw. Section Abstract Doc Link 10903797 Disease Relevance 0.33 Pain Relevance 0.37
In addition, up-regulation of TNF production by S-isomers is associated with inhibition of interleukin-10 (IL-10) production.
Negative_regulation (inhibition) of Gene_expression (production) of interleukin-10
9) Confidence 0.38 Published 2000 Journal Eur. Cytokine Netw. Section Abstract Doc Link 10903797 Disease Relevance 0.54 Pain Relevance 0.42
As already observed, a persisting increase of IL-10 production was observed in the FA model (silica) which paralleled the establishment of lung fibrosis (Figure 5 A).
Negative_regulation (persisting) of Gene_expression (production) of IL-10 in lung associated with fibrosis and pulmonary fibrosis
10) Confidence 0.36 Published 2005 Journal Respir Res Section Body Doc Link PMC1274346 Disease Relevance 1.70 Pain Relevance 0.52
In a similar pattern, the reduced gene expression of IL-10 was concordant between the iNOS inhibitor AG treated- and iNOS-KO-mice, and the eNOS inhibitor L-NIO treated- and eNOS-KO-mice.
Negative_regulation (reduced) of Gene_expression (expression) of IL-10 associated with targeted disruption
11) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2838835 Disease Relevance 0.72 Pain Relevance 0.13
We also observed decreased IL-10 production and increased levels of proinflammatory cytokines in blood and brain of E. coli–infected neonatal mice 24 h after infection.
Negative_regulation (decreased) of Gene_expression (production) of IL-10 in blood associated with infection and cytokine
12) Confidence 0.33 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.72 Pain Relevance 0.17
However, our preliminary cytofluorimetric analysis seems to indicate that IL-10 production is decreased mainly in CD3+ lymphocytes [Franchi et al., unpublished results].
Negative_regulation (decreased) of Gene_expression (production) of IL-10 in lymphocytes
13) Confidence 0.31 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.14 Pain Relevance 0.13
Moreover, methotrexate treatment augmented the accumulation of IL-10, a known anti-inflammatory cytokine, in wild-type mice and A3 knockout mice, but actually decreased IL-10 levels in A2A knockout mice.
Negative_regulation (decreased) of Gene_expression (levels) of IL-10 associated with targeted disruption, inflammation, methotrexate and cytokine
14) Confidence 0.29 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526598 Disease Relevance 1.09 Pain Relevance 1.06
The inhibitory effect of vitamin D3 seems to be similar to that of IL-27, which inhibits the lineage commitment of TH17 cells [33, 41–43 51] and induces IL-10 production, which, in turn, suppresses EAE initiation [34].
Negative_regulation (suppresses) of Gene_expression (production) of IL-10 associated with multiple sclerosis
15) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0.10 Pain Relevance 0
and IL-10 and a decreased expression of IFN-?
Negative_regulation (decreased) of Gene_expression (expression) of IL-10
16) Confidence 0.26 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2255028 Disease Relevance 0.61 Pain Relevance 0.13
However, diminished production of IL-10 mRNA and IL-10 protein in term and preterm neonates compared with adults was observed after stimulating with LPS (Schultz et al., 2004).
Negative_regulation (diminished) of Gene_expression (production) of IL-10 protein
17) Confidence 0.25 Published 2010 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2882833 Disease Relevance 0.79 Pain Relevance 0.19
Other studies have shown that mesenchymal stem cells are inherently immunosuppressive through production of PGE-2, interleukin-10 and expression of the tryptophan catabolizing enzyme indoleamine 2,3,-dioxygenase as well as Galectin-1 [125,126].
Negative_regulation (immunosuppressive) of Gene_expression (production) of interleukin-10 in stem cells
18) Confidence 0.24 Published 2007 Journal J Transl Med Section Body Doc Link PMC1914111 Disease Relevance 0.12 Pain Relevance 0
As shown in Figure 8, and as observed in the BalbC mice, the in vivo administration of Bv8 at either time significantly decreased IL-10 production in the WT animals but not in the in the PROKR 1 KO mice.


Negative_regulation (decreased) of Gene_expression (production) of IL-10
19) Confidence 0.23 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.27 Pain Relevance 0.14
However, as shown in panel C, the in vitro addition of Bv8 significantly reduced Con-A induced IL-10 production at concentrations of 10-11, 10-9 and 10-7 M.
Negative_regulation (reduced) of Gene_expression (production) of IL-10
20) Confidence 0.23 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0 Pain Relevance 0.15

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