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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.37
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MAP2K1) Golgi apparatus (MAP2K1) cytoplasm (MAP2K1)
cytosol (MAP2K1) signal transduction (MAP2K1) mitosis (MAP2K1)
Anatomy Link Frequency
epithelial cells 2
MAP2K1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 99.98 Very High Very High Very High
narcan 1 87.92 High High
antagonist 2 86.24 High High
opioid receptor 1 80.48 Quite High
addiction 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 21 89.84 High High
Breast Cancer 28 76.04 Quite High
Infection 6 5.00 Very Low Very Low Very Low
Apoptosis 3 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low
Adenocarcinoma 1 5.00 Very Low Very Low Very Low
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).
Positive_regulation (enhanced) of Gene_expression (levels) of MEK1 associated with morphine
1) Confidence 0.36 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.81
induces cell transformation in multiple cell types including human embryonic kidney and human mammary epithelial cells expressing hTERT, the SV40 Early Region, and constitutively active MEK (Fig. 6A), as well as in NIH 3T3 mouse fibroblasts (data not shown).
Positive_regulation (active) of Gene_expression (expressing) of MEK in epithelial cells
2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.37 Pain Relevance 0

General Comments

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