INT71778

Context Info Confidence 0.36 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.37 Pain Relevance 0.81

mitochondrion (MAP2K1) Golgi apparatus (MAP2K1) cytoplasm (MAP2K1) cytosol (MAP2K1) signal transduction (MAP2K1) mitosis (MAP2K1)

Anatomy Link Frequency epithelial cells 2 MAP2K1 (Homo sapiens)

Pain Link Frequency Relevance Heat Morphine 8 99.98 narcan 1 87.92 antagonist 2 86.24 opioid receptor 1 80.48 addiction 2 5.00 cINOD 2 5.00

Disease Link Frequency Relevance Heat Cancer 21 89.84 Breast Cancer 28 76.04 Infection 6 5.00 Apoptosis 3 5.00 Hyperplasia 1 5.00 Adenocarcinoma 1 5.00 INFLAMMATION 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).

Positive_regulation (enhanced) of Gene_expression (levels) of MEK1 associated with morphine

1) Confidence 0.36 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.81

induces cell transformation in multiple cell types including human embryonic kidney and human mammary epithelial cells expressing hTERT, the SV40 Early Region, and constitutively active MEK (Fig. 6A), as well as in NIH 3T3 mouse fibroblasts (data not shown).

Positive_regulation (active) of Gene_expression (expressing) of MEK in epithelial cells

2) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.37 Pain Relevance 0

General Comments

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