INT71779

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Context Info
Confidence 0.47
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 27
Total Number 31
Disease Relevance 21.41
Pain Relevance 5.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
fibroblasts 10
cartilage 4
arms 4
epithelial cells 4
eosinophils 2
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 525 99.98 Very High Very High Very High
Morphine 16 99.98 Very High Very High Very High
COX2 3 99.56 Very High Very High Very High
agonist 15 99.42 Very High Very High Very High
metalloproteinase 33 98.94 Very High Very High Very High
Inflammation 237 98.92 Very High Very High Very High
Osteoarthritis 68 98.28 Very High Very High Very High
Nicotine 5 97.52 Very High Very High Very High
cytokine 79 90.24 High High
narcan 2 87.44 High High
Disease Link Frequency Relevance Heat
Stress 759 100.00 Very High Very High Very High
Chronic Hepatitis 62 99.84 Very High Very High Very High
Colon Cancer 45 99.48 Very High Very High Very High
Eosinophilic Esophagitis 106 99.36 Very High Very High Very High
Nasopharynx Cancer 145 99.32 Very High Very High Very High
Cirrhosis 114 99.32 Very High Very High Very High
Inflammatory Breast Neoplasms 4 99.20 Very High Very High Very High
Disease 1425 99.16 Very High Very High Very High
Infection 121 98.96 Very High Very High Very High
Lung Injury 9 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).
Positive_regulation (enhanced) of Gene_expression (levels) of ERK associated with morphine
1) Confidence 0.47 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.81
Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).
Positive_regulation (enhanced) of Gene_expression (levels) of ERK2 associated with morphine
2) Confidence 0.47 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.80
Intracellular Ca(2+) triggered the activation of mitogen-activated protein kinase (MAPK) in HMC-1, especially p42 and p44 isoforms of extracellular signal-regulated kinase (ERK) and p38 MAPK, but not c-Jun N-terminal kinase (JNK).
Positive_regulation (activation) of Gene_expression (isoforms) of ERK
3) Confidence 0.43 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.17 Pain Relevance 0.21
Intracellular Ca(2+) triggered the activation of mitogen-activated protein kinase (MAPK) in HMC-1, especially p42 and p44 isoforms of extracellular signal-regulated kinase (ERK) and p38 MAPK, but not c-Jun N-terminal kinase (JNK).
Positive_regulation (activation) of Gene_expression (isoforms) of extracellular signal-regulated kinase
4) Confidence 0.43 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.17 Pain Relevance 0.21
Our data showed an increased expression of ERK in the PBMC of EoE subjects, and it is possible that, together with eotaxin, FGF enhances activation of eosinophils in EoE specifically.
Positive_regulation (increased) of Gene_expression (expression) of ERK in eosinophils associated with eosinophilic esophagitis
5) Confidence 0.43 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 0.67 Pain Relevance 0
Hydrogen peroxide-induced oxidative stress evokes lagging ERK activation and enhanced JNK activation in AD fibroblasts
Positive_regulation (induced) of Gene_expression (activation) of ERK in fibroblasts associated with stress and disease
6) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.29 Pain Relevance 0.43
Similarly to ERK, the stress-activated MAPK modules of JNK (Figure 4A–C) and p38 (Figure 5A–C) were both activated by both BK concentrations and showed a diminished response in the PS-1 (M146L) fibroblasts.
Positive_regulation (activated) of Gene_expression (modules) of p38 in fibroblasts associated with stress and bradykinin
7) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.74 Pain Relevance 0.28
In the presence of DMSO vehicle alone, BK-stimulated ERK activation was significantly decreased (2 fold) in PS-1 (M146L) AD fibroblasts relative to controls (Figure 8A–B).
Positive_regulation (stimulated) of Gene_expression (activation) of ERK in fibroblasts associated with disease and bradykinin
8) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.81 Pain Relevance 0.48
Cell lysates collected in 1% SDS were immunoblotted for expression and activation of ERK, JNK and p38 and normalized to the loading control protein tubulin.
Positive_regulation (activation) of Gene_expression (expression) of p38
9) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.41 Pain Relevance 0.25
Thus H2O2-induced oxidative stress resulted in early lagging ERK and later enhanced JNK activation in the PS-1 (M146L) AD fibroblasts.
Positive_regulation (enhanced) of Gene_expression (activation) of ERK in fibroblasts associated with stress and disease
10) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.52 Pain Relevance 0
Similarly to ERK, the stress-activated MAPK modules of JNK (Figure 4A–C) and p38 (Figure 5A–C) were both activated by both BK concentrations and showed a diminished response in the PS-1 (M146L) fibroblasts.
Positive_regulation (activated) of Gene_expression (modules) of p38 in fibroblasts associated with stress and bradykinin
11) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.74 Pain Relevance 0.28
Cell lysates collected in 1% SDS were immunoblotted for expression and activation of ERK, JNK and p38 and normalized to the loading control protein tubulin.
Positive_regulation (activation) of Gene_expression (expression) of ERK
12) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.35 Pain Relevance 0.25
Blocking of p38, ERK, or JNK with SB203580 (P<0.0001), PD98059 (P<0.0001), or SP600125 (P<0.0001), respectively, impaired histamine-induced TF expression in a concentration-dependent manner.
Positive_regulation (induced) of Gene_expression (expression) of ERK
13) Confidence 0.31 Published 2005 Journal Circulation Section Body Doc Link 16009787 Disease Relevance 0 Pain Relevance 0
Our laboratory has previously demonstrated that RhoC can mediate inflammatory breast cancer cell migration and invasion through co-activation of the p42/p44 Erk and p38 arms of the MAPK pathway [40].
Positive_regulation (activation) of Gene_expression (arms) of p38 in arms associated with inflammation
14) Confidence 0.30 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.26 Pain Relevance 0.05
Adopting immunohistochemistry labeled streptavidin biotin method, overexpression of epidermal growth factor receptor and phosphorylated extracellular signal-regulated kinase was detected in NPC.
Positive_regulation (overexpression) of Gene_expression (overexpression) of extracellular signal-regulated kinase associated with nasopharynx cancer
15) Confidence 0.28 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.73 Pain Relevance 0
Our laboratory has previously demonstrated that RhoC can mediate inflammatory breast cancer cell migration and invasion through co-activation of the p42/p44 Erk and p38 arms of the MAPK pathway [40].
Positive_regulation (activation) of Gene_expression (arms) of Erk in arms associated with inflammation
16) Confidence 0.26 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.26 Pain Relevance 0.05
Specific PAR-2 activation stimulates major pathophysiological pathways involved in the OA process, including MMP-1 and MMP-13 as well as cyclooxygenase 2 (COX-2), through the activation of extracellular signal-regulated kinase 1/2 (Erk1/2) and p38.


Positive_regulation (activation) of Gene_expression (/) of p38 associated with metalloproteinase, cox2 and osteoarthritis
17) Confidence 0.24 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246240 Disease Relevance 1.27 Pain Relevance 0.69
Substrates of p38 MAPK
Positive_regulation (Substrates) of Gene_expression (Substrates) of p38 MAPK
18) Confidence 0.24 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0
Treatment with A3AR agonist before reperfusion markedly increased ERK1 and ERK2 expression and attenuated reperfusion lung injury and apoptosis, thus presenting a promising approach for moderating lung injury and supporting recovery after clinical I/R.


Positive_regulation (increased) of Gene_expression (expression) of ERK2 in lung associated with lung injury, agonist and apoptosis
19) Confidence 0.17 Published 2007 Journal Crit Care Section Body Doc Link PMC2206506 Disease Relevance 1.39 Pain Relevance 0.30
7 nAChR-dependent signals including ERK
Positive_regulation (dependent) of Gene_expression (signals) of ERK
20) Confidence 0.13 Published 2008 Journal PPAR Research Section Body Doc Link PMC2515882 Disease Relevance 0.98 Pain Relevance 0.22

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