INT71780

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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 17.21
Pain Relevance 1.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (TYR) cell proliferation (TYR) lysosome (TYR)
cytoplasm (TYR)
Anatomy Link Frequency
Bands 1
TYR (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 150 99.70 Very High Very High Very High
narcan 1 96.48 Very High Very High Very High
Morphine 8 95.52 Very High Very High Very High
antagonist 1 94.80 High High
Pain 2 92.32 High High
alcohol 48 90.88 High High
opioid receptor 1 89.04 High High
Neuropeptide 2 85.48 High High
Inflammation 48 84.96 Quite High
Eae 6 78.40 Quite High
Disease Link Frequency Relevance Heat
Cirrhosis 456 99.76 Very High Very High Very High
Hepatitis 264 99.20 Very High Very High Very High
Chronic Hepatitis 248 99.16 Very High Very High Very High
Disease 450 99.04 Very High Very High Very High
Fibrosis 72 96.40 Very High Very High Very High
Pain 2 92.32 High High
Injury 6 91.92 High High
Head Trauma 4 91.64 High High
Infection 40 91.60 High High
Stroke 2 91.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a PKC-dependent process the BK B2 subtype receptor (BKB2R) is modulated to forms that reflect activity of a Tyr phosphorylation pathway [13].
Phosphorylation (phosphorylation) of Tyr associated with bradykinin
1) Confidence 0.34 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 1.85 Pain Relevance 0.47
A common element of this molecular profile appearing in all presenilin and non-presenilin-based genetic forms of AD risk we tested is the initial BK-induced BKB2R Tyr phosphorylation itself, positioned early in the BKB2R signaling cascade [8], [12], [13], [14].
Phosphorylation (phosphorylation) of Tyr associated with disease and bradykinin
2) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2644820 Disease Relevance 0.86 Pain Relevance 0.08
A time-dependent increase in the activated (Thr and Tyr dually phosphorylated) state of ERK1 and ERK2 was also observed.
Phosphorylation (phosphorylated) of Tyr
3) Confidence 0.27 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.83
As the amount of STAT3-Tyr phosphorylation indicates the DNA binding capacity of the protein, the pathways seems to be activated in fibrotic diseases and not in acute hepatitis.
Phosphorylation (phosphorylation) of Tyr associated with fibrosis, disease and hepatitis
4) Confidence 0.22 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.62 Pain Relevance 0.04
The levels of STAT3-Tyr phosphorylation were the lowest in AH and strongest in LDH.
Phosphorylation (phosphorylation) of Tyr associated with hepatitis
5) Confidence 0.22 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.73 Pain Relevance 0.04
The phosphorylated form threonine/tyrosine (Thr/Tyr)-phosphorylated ERK1/2 was strongly increased in CH and LDH.
Phosphorylation (phosphorylated) of Tyr associated with chronic hepatitis
6) Confidence 0.19 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 2.14 Pain Relevance 0.04
Tyrosine (Tyr)-phosphorylated STAT3 was strongly reduced in AH and was increased in LDH.
Phosphorylation (phosphorylated) of Tyr associated with hepatitis
7) Confidence 0.19 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.59 Pain Relevance 0
The threonine/tyrosine (Thr/Tyr)-phosphorylated p38-MAPK form is increased in CH, LDH, and CIRR.


Phosphorylation (phosphorylated) of Tyr associated with chronic hepatitis and cirrhosis
8) Confidence 0.19 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 2.02 Pain Relevance 0.05
The phosphorylated form threonine/tyrosine (Thr/Tyr)-phosphorylated ERK1/2 was strongly increased in CH and LDH.
Phosphorylation (phosphorylated) of Tyr associated with chronic hepatitis
9) Confidence 0.15 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 2.12 Pain Relevance 0.04
The phosphorylated form of c-MET (Tyr) was detected in all samples.
Phosphorylation (phosphorylated) of Tyr
10) Confidence 0.15 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.46 Pain Relevance 0.04
Healthy controls, CH, and CIRR groups had comparable levels of Tyr-phosphorylated STAT3.
Phosphorylation (phosphorylated) of Tyr associated with chronic hepatitis and cirrhosis
11) Confidence 0.15 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1971050 Disease Relevance 1.76 Pain Relevance 0
Bands at 250, 130 and 100 kDa that displayed a consistent increase in intensity (indicating either an increase in Tyr phosphorylation or a binding to such a protein in the immunoprecipitate) after stretch were subjected mass spectrometric analysis.
Phosphorylation (phosphorylation) of Tyr in Bands
12) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2759504 Disease Relevance 0.06 Pain Relevance 0

General Comments

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