INT71781

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Context Info
Confidence 0.80
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 62
Total Number 63
Disease Relevance 27.73
Pain Relevance 23.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
fibroblast 4
colon 4
brain 2
platelets 2
ESCs 2
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 65 99.86 Very High Very High Very High
bradykinin 14 99.82 Very High Very High Very High
fluoxetine 29 99.80 Very High Very High Very High
Cannabinoid 59 99.70 Very High Very High Very High
nMDA receptor 12 99.28 Very High Very High Very High
Cannabinoid receptor 234 99.24 Very High Very High Very High
tolerance 21 99.16 Very High Very High Very High
Morphine 25 99.08 Very High Very High Very High
Opioid 21 99.08 Very High Very High Very High
Dynorphin 5 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 23 99.84 Very High Very High Very High
Colon Cancer 250 99.48 Very High Very High Very High
Apoptosis 309 99.24 Very High Very High Very High
Targeted Disruption 30 99.10 Very High Very High Very High
Hyperplasia 11 98.82 Very High Very High Very High
Urological Neuroanatomy 8 98.72 Very High Very High Very High
Cancer 334 98.52 Very High Very High Very High
Nerve Sheath Neoplasms 132 98.48 Very High Very High Very High
Osteoarthritis 106 98.24 Very High Very High Very High
Frailty 630 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Apoptosis and cell cycle arrest appeared to be independent of derivative induced inhibition of PDK1 and phosphorylation of Akt and Erk1/2.
Phosphorylation (phosphorylation) of Erk1 associated with apoptosis
1) Confidence 0.80 Published 2005 Journal Int. J. Cancer Section Abstract Doc Link 15499625 Disease Relevance 1.28 Pain Relevance 0.12
Both cirazoline- and insulin-mediated glucose uptake were inhibited by protein kinase C (PKC), phospholipase C, and p38 kinase inhibitors, but not by Erk1/2 inhibitors (despite both treatments being able to phosphorylate Erk1/2).
Phosphorylation (phosphorylate) of Erk1 associated with kinase c
2) Confidence 0.80 Published 2005 Journal Endocrinology Section Abstract Doc Link 15550506 Disease Relevance 0 Pain Relevance 0.41
These compounds induced phosphorylation of extracellular signal-regulated kinase1/2 (Erk1/2), whereas a dominant-negative inhibitor of mitogen-activate protein kinase kinase (MEK) 1 blocked the induction of ATF3.
Phosphorylation (phosphorylation) of Erk1
3) Confidence 0.80 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16079301 Disease Relevance 0.17 Pain Relevance 0.05
Pharmacologic activation of PKG with YC-1 increases JNK phosphorylation and induces apoptosis in colon cancer cells without modulating ERK1/2 phosphorylation or beta-catenin protein expression.
Phosphorylation (phosphorylation) of ERK1 in colon associated with colon cancer and apoptosis
4) Confidence 0.80 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 1.12 Pain Relevance 0.13
Induction of expression of the modified cannabinoid CB1 receptor did not limit DAMGO-mediated ERK1/2 MAP kinase phosphorylation and did not allow SR141716A to enhance the function of DAMGO.
Phosphorylation (phosphorylation) of ERK1 associated with cannabinoid
5) Confidence 0.80 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.69
This allowed the cannabinoid CB1 agonist WIN55212-2 to stimulate ERK1/2 phosphorylation but resulted in a large reduction in the capacity of DAMGO to activate these kinases.
Phosphorylation (phosphorylation) of ERK1 associated with cannabinoid and agonist
6) Confidence 0.80 Published 2008 Journal J. Biol. Chem. Section Abstract Doc Link 18319252 Disease Relevance 0 Pain Relevance 0.73
Prolonged (12h) exposure of SH-SY5Y neuroblastoma cells to the mu-opioid receptor (MOPr) agonist [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (DAMGO) causes homologous desensitization as well as heterologous desensitization of the extracellular signal-regulated kinase 1/2 (ERK 1/2) phosphorylation induced by insulin-like growth factor (IGF)-I.
Phosphorylation (phosphorylation) of ERK 1 in SH-SY5Y associated with neuroblastoma, agonist, enkephalin and opioid receptor
7) Confidence 0.80 Published 2010 Journal FEBS Lett. Section Abstract Doc Link 20643133 Disease Relevance 0.17 Pain Relevance 0.35
In this connection, PGE(2) and butaprost induced phosphorylation of extracellular signal-regulated kinases 1/2 (Erk1/2), whose down-regulation by RNA interference significantly attenuated PGE(2)-induced cell proliferation.
Phosphorylation (phosphorylation) of Erk1
8) Confidence 0.80 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18583546 Disease Relevance 0.53 Pain Relevance 0.10
Intriguingly, we revealed remarkable defects in NT3-induced ERK1/2 phosphorylation and neurite outgrowth.
Phosphorylation (phosphorylation) of ERK1 in neurite
9) Confidence 0.80 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20188729 Disease Relevance 0.55 Pain Relevance 0.28
We demonstrate that FLX inhibits phosphorylation of ERK1/2 kinases in a time and concentration-dependent manner, followed by reduced phosphorylation of transcription factor c-Myc in A549 and HT29 cells.
Phosphorylation (phosphorylation) of ERK1 in HT29 associated with fluoxetine
10) Confidence 0.80 Published 2008 Journal Cancer Biol. Ther. Section Abstract Doc Link 18836303 Disease Relevance 0.84 Pain Relevance 0.93
Both CAP and WIN induced transient increases in Erk1/2, p38, JNK1/2 MAPK and Akt/PI-3K phosphorylation status resulting in cell proliferation and migration increases which mirrored those elicited by EGF.
Phosphorylation (phosphorylation) of Erk1
11) Confidence 0.80 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.14 Pain Relevance 0.63
Thrombin induced phosphorylation of ERK1/2 and p38 in MDMs.
Phosphorylation (phosphorylation) of ERK1 in MDMs
12) Confidence 0.80 Published 2009 Journal Blood Section Abstract Doc Link 19652200 Disease Relevance 0.98 Pain Relevance 0.30
Functional coupling of G alpha(i2)/z to the opioid receptors was demonstrated by opioid-induced inhibition of adenylyl cyclase and stimulation of ERK1/2 phosphorylation in PTX-treated cells.
Phosphorylation (phosphorylation) of ERK1 associated with opioid receptor and opioid
13) Confidence 0.80 Published 2000 Journal Neuroreport Section Abstract Doc Link 11043551 Disease Relevance 0.08 Pain Relevance 0.57
Despite a complete blockade of ERK1/2 phosphorylation, U0126 did not affect opioid-induced AC superactivation, indicating that ERK1/2 activity was not required for opioid-induced AC superactivation in HEK 293 cells.
Phosphorylation (phosphorylation) of ERK1 in HEK associated with opioid
14) Confidence 0.80 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11720767 Disease Relevance 0 Pain Relevance 0.70
In addition, morphine also elevated the levels of PKC activity and phosphorylated ERK1/2.
Phosphorylation (phosphorylated) of ERK1 associated with morphine
15) Confidence 0.80 Published 2004 Journal Toxicol In Vitro Section Abstract Doc Link 15130602 Disease Relevance 0.64 Pain Relevance 0.60
Cell cycle analysis was carried out by flow cytometry, the phosphorylation of mitogen-activated protein kinases ERK1 and ERK2 was detected by Western blotting assay, and changes of calcium concentration were monitored by scanning intracellular fluorescence intensity.
Phosphorylation (phosphorylation) of ERK1
16) Confidence 0.80 Published 2004 Journal Toxicol In Vitro Section Abstract Doc Link 15130602 Disease Relevance 0.79 Pain Relevance 0.56
The importance of activated MAP kinases for DOR internalization is further demonstrated by glutamate and paclitaxel because these substances induce phosphorylation of ERK1/2 and concomitantly prevent DOR sequestration by etorphine.
Phosphorylation (phosphorylation) of ERK1 associated with glutamate and immobilon
17) Confidence 0.80 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 14742744 Disease Relevance 0 Pain Relevance 1.02
Treatment of HCT116 human colon cancer cells with the specific mitogen-activated protein kinase kinase, U0126 (5-50 microM) resulted in a time- and dose-dependent inhibition of ERK1/2 phosphorylation, and induction of apoptosis.
Phosphorylation (phosphorylation) of ERK1 in colon associated with colon cancer and apoptosis
18) Confidence 0.79 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11245463 Disease Relevance 0.97 Pain Relevance 0.15
In the present study we used immunoblotting techniques to examine the effects of acute and repeated restraint stress on the phosphorylation state of three MAPKs, the extracellular signal-regulated kinase Erk1/2, c-Jun-N-terminal kinase/stress-activated protein kinase (JNK/SAPK) and p38 MAPK, in different brain regions.
Phosphorylation (phosphorylation) of Erk1 in brain associated with stress
19) Confidence 0.79 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850571 Disease Relevance 0.46 Pain Relevance 0.18
The association of beta-arrestin2 with the heterodimer can be altered by treatment with a combination of muOR agonist (DAMGO) and deltaOR antagonist (Tipp(psi)), and this leads to a shift in the pattern of ERK1/2 phosphorylation to the pattern observed with muOR alone.
Phosphorylation (phosphorylation) of ERK1 associated with antagonist and agonist
20) Confidence 0.79 Published 2007 Journal FASEB J. Section Abstract Doc Link 17384143 Disease Relevance 0.07 Pain Relevance 0.48

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