INT71783

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.59
Pain Relevance 3.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
brain 4
lung 2
PFCX 2
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 13 99.98 Very High Very High Very High
fluoxetine 7 99.74 Very High Very High Very High
agonist 5 99.42 Very High Very High Very High
cocaine 9 99.20 Very High Very High Very High
Hippocampus 3 98.48 Very High Very High Very High
addiction 2 86.04 High High
Inflammation 7 84.76 Quite High
narcan 1 84.40 Quite High
Visceral pain 2 84.32 Quite High
antagonist 1 82.72 Quite High
Disease Link Frequency Relevance Heat
Stress 19 100.00 Very High Very High Very High
Urological Neuroanatomy 5 99.64 Very High Very High Very High
Colon Cancer 45 99.48 Very High Very High Very High
Lung Injury 9 98.88 Very High Very High Very High
Apoptosis 22 98.24 Very High Very High Very High
Cancer 38 96.72 Very High Very High Very High
Shock 7 85.44 High High
Sepsis 46 85.04 High High
INFLAMMATION 10 84.76 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 84.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).
Positive_regulation (enhanced) of Gene_expression (levels) of ERK1 associated with morphine
1) Confidence 0.59 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.80
A single exposure to 30 min of restraint stress-elevated phospho-Erk1/2 (P-Erk1/2) levels in all three brain regions examined (hippocampus, medial prefrontal cortex and cingulate cortex), but did not alter the phosphorylation pattern of the other two MAPKs in any region.
Positive_regulation (stress-elevated) of Gene_expression (levels) of Erk1 in brain associated with stress and hippocampus
2) Confidence 0.49 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850571 Disease Relevance 0.45 Pain Relevance 0.17
A single exposure to 30 min of restraint stress-elevated phospho-Erk1/2 (P-Erk1/2) levels in all three brain regions examined (hippocampus, medial prefrontal cortex and cingulate cortex), but did not alter the phosphorylation pattern of the other two MAPKs in any region.
Positive_regulation (stress-elevated) of Gene_expression (levels) of Erk1 in brain associated with stress and hippocampus
3) Confidence 0.49 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850571 Disease Relevance 0.45 Pain Relevance 0.17
Again in PFCX, FLX selectively increased the expression level of MAP kinases Erk1/2, without affecting their phosphorylation.
Positive_regulation (increased) of Gene_expression (expression) of Erk1 in PFCX associated with urological neuroanatomy and fluoxetine
4) Confidence 0.49 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138445 Disease Relevance 0.40 Pain Relevance 0.62
In addition, KOR agonists activate kinase cascades including G-protein coupled Receptor Kinases (GRK) and members of the mitogen-activated protein kinase (MAPK) family: ERK1/2, p38 and JNK.
Positive_regulation (activate) of Gene_expression (/) of ERK1
5) Confidence 0.49 Published 2010 Journal Psychopharmacology (Berl.) Section Body Doc Link 20401607 Disease Relevance 0.15 Pain Relevance 0
In addition, morphine also elevated the levels of PKC activity and phosphorylated ERK1/2.
Positive_regulation (elevated) of Gene_expression (levels) of ERK1 associated with morphine
6) Confidence 0.45 Published 2004 Journal Toxicol In Vitro Section Abstract Doc Link 15130602 Disease Relevance 0.65 Pain Relevance 0.61
We report here that deletion of the ERK1 isoform, which leads to increased ERK2 stimulus-dependent signaling, facilitates the development of cocaine-induced psychomotor sensitization and the acquisition of a cocaine conditioned place preference.
Positive_regulation (facilitates) of Gene_expression (deletion) of ERK1 associated with cocaine
7) Confidence 0.22 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16407894 Disease Relevance 0.07 Pain Relevance 0.38
Treatment with A3AR agonist before reperfusion markedly increased ERK1 and ERK2 expression and attenuated reperfusion lung injury and apoptosis, thus presenting a promising approach for moderating lung injury and supporting recovery after clinical I/R.


Positive_regulation (increased) of Gene_expression (expression) of ERK1 in lung associated with lung injury, agonist and apoptosis
8) Confidence 0.17 Published 2007 Journal Crit Care Section Body Doc Link PMC2206506 Disease Relevance 1.39 Pain Relevance 0.30
Third, activating phosphorylation of ERK1/ERK2 MAP kinases is frequently observed in human colorectal cancer cell lines and tumor specimens [20].
Positive_regulation (activating) of Gene_expression (/) of ERK1 associated with cancer and colon cancer
9) Confidence 0.09 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2596176 Disease Relevance 0.86 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox