INT71784

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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.80
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K1) cytoskeleton (MAP3K1) cytoplasm (MAP3K1)
Anatomy Link Frequency
cleavage 4
salivary gland 2
MAP3K1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 8 99.98 Very High Very High Very High
narcan 1 89.44 High High
antagonist 1 87.76 High High
opioid receptor 1 82.00 Quite High
Kinase C 2 35.08 Quite Low
dexamethasone 16 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
palliative 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 44 98.84 Very High Very High Very High
Carcinoma 91 98.60 Very High Very High Very High
Cancer 122 96.96 Very High Very High Very High
Mastocytoma 2 93.52 High High
Osteogenic Sarcomas 2 92.84 High High
Breast Cancer 23 92.28 High High
Retinoblastoma 2 90.52 High High
Prostate Cancer 26 86.04 High High
Bladder Cancer 10 78.72 Quite High
Apoptosis 35 62.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).
Positive_regulation (enhanced) of Gene_expression (levels) of MEKK associated with morphine
1) Confidence 0.34 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.82
Calcitriol promotes the expression of mitogen-activated protein kinase kinase kinase (MEKK-1) and the cleavage of caspase 3 when used in combination with cisplatin in SCC cells 18.
Positive_regulation (cleavage) of Gene_expression (expression) of MEKK-1 in cleavage associated with skin cancer
2) Confidence 0.07 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 2.04 Pain Relevance 0
Calcitriol promotes the expression of mitogen-activated protein kinase kinase kinase (MEKK-1) and the cleavage of caspase 3 when used in combination with cisplatin in SCC cells 18.
Positive_regulation (promotes) of Gene_expression (expression) of MEKK-1 in cleavage associated with skin cancer
3) Confidence 0.07 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 2.04 Pain Relevance 0
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy

Background

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of kinase 1 in salivary gland associated with carcinoma
4) Confidence 0.01 Published 2010 Journal BMC Cancer Section Title Doc Link PMC2949806 Disease Relevance 0.72 Pain Relevance 0

General Comments

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