INT71785

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 22
Total Number 24
Disease Relevance 11.35
Pain Relevance 8.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
brain 2
spinal cord 1
fibroblast 1
lung 1
endometrium 1
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 13 99.62 Very High Very High Very High
Inflammation 214 99.52 Very High Very High Very High
fluoxetine 7 99.46 Very High Very High Very High
Dynorphin 7 99.36 Very High Very High Very High
agonist 77 99.22 Very High Very High Very High
cytokine 79 99.00 Very High Very High Very High
Lasting pain 3 98.92 Very High Very High Very High
Hippocampus 3 98.48 Very High Very High Very High
Pain 38 98.28 Very High Very High Very High
Spinal cord 8 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 21 99.64 Very High Very High Very High
INFLAMMATION 246 99.52 Very High Very High Very High
Urological Neuroanatomy 5 99.36 Very High Very High Very High
Meningoencephalitis 8 99.24 Very High Very High Very High
Pain 30 98.92 Very High Very High Very High
Lung Injury 9 98.88 Very High Very High Very High
Neuroma 10 98.64 Very High Very High Very High
Apoptosis 68 98.56 Very High Very High Very High
Colon Cancer 52 98.28 Very High Very High Very High
Cancer 107 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
INTERPRETATION: These results demonstrate that multiple sodium channel isoforms (Nav1.3, Nav1.7, and Nav1.8), as well as activated p38 and ERK1/2 MAP kinases, are expressed in painful human neuromas, indicating that these molecules merit study as possible therapeutic targets for the treatment of pain associated with traumatic neuromas.


Gene_expression (expressed) of ERK1
1) Confidence 0.75 Published 2008 Journal Ann. Neurol. Section Body Doc Link 19107992 Disease Relevance 0.14 Pain Relevance 0
Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).
Gene_expression (levels) of ERK1 associated with morphine
2) Confidence 0.66 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.80
In addition, KOR agonists activate kinase cascades including G-protein coupled Receptor Kinases (GRK) and members of the mitogen-activated protein kinase (MAPK) family: ERK1/2, p38 and JNK.
Gene_expression (/) of ERK1
3) Confidence 0.65 Published 2010 Journal Psychopharmacology (Berl.) Section Body Doc Link 20401607 Disease Relevance 0.14 Pain Relevance 0
Moreover, prodynorphin (mRNA, real-time polymerase chain reaction), dynorphin (enzymatic immunoassay), c-Fos expression, and ERK1/2 phosphorylation (both by immunohistochemistry) in the lumbar spinal cord were assessed.
Gene_expression (expression) of ERK1 in spinal cord associated with dynorphin and spinal cord
4) Confidence 0.65 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 19917879 Disease Relevance 0.35 Pain Relevance 1.06
Sulindac metabolites simultaneously (a) increase cellular cyclic GMP and subsequently activate cyclic GMP-dependent protein kinase (PKG); (b) activate c-jun NH2-terminal kinase (JNK); (c) inhibit extracellular signal-regulated kinase 1/2 (ERK1/2); and (d) decrease beta-catenin protein expression at times and doses consistent with apoptosis.
Gene_expression (expression) of ERK1 associated with apoptosis
5) Confidence 0.65 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16546990 Disease Relevance 0.99 Pain Relevance 0.16
Again in PFCX, FLX selectively increased the expression level of MAP kinases Erk1/2, without affecting their phosphorylation.
Gene_expression (expression) of Erk1 in PFCX associated with urological neuroanatomy and fluoxetine
6) Confidence 0.65 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138445 Disease Relevance 0.40 Pain Relevance 0.61
A single exposure to 30 min of restraint stress-elevated phospho-Erk1/2 (P-Erk1/2) levels in all three brain regions examined (hippocampus, medial prefrontal cortex and cingulate cortex), but did not alter the phosphorylation pattern of the other two MAPKs in any region.
Gene_expression (levels) of Erk1 in brain associated with stress and hippocampus
7) Confidence 0.65 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850571 Disease Relevance 0.44 Pain Relevance 0.17
A single exposure to 30 min of restraint stress-elevated phospho-Erk1/2 (P-Erk1/2) levels in all three brain regions examined (hippocampus, medial prefrontal cortex and cingulate cortex), but did not alter the phosphorylation pattern of the other two MAPKs in any region.
Gene_expression (levels) of Erk1 in brain associated with stress and hippocampus
8) Confidence 0.65 Published 2003 Journal Brain Res. Section Abstract Doc Link 12850571 Disease Relevance 0.44 Pain Relevance 0.17
In addition, morphine also elevated the levels of PKC activity and phosphorylated ERK1/2.
Gene_expression (levels) of ERK1 associated with morphine
9) Confidence 0.58 Published 2004 Journal Toxicol In Vitro Section Abstract Doc Link 15130602 Disease Relevance 0.65 Pain Relevance 0.61
DESIGN: ERK1/2 phosphorylation and expression throughout the menstrual cycle were evaluated in vivo in normal and endometriotic human endometrium, and in vitro techniques assessed the steroidal regulation of ERK1/2 and its effect on endometrial cell survival.
Gene_expression (expression) of ERK1 in endometrium
10) Confidence 0.58 Published 2008 Journal J. Clin. Endocrinol. Metab. Section Body Doc Link 18559923 Disease Relevance 0 Pain Relevance 0
We also examined the expression of two mitogen-activated protein (MAP) kinases, activated p38 and extracellular signal-regulated kinases 1 and 2 (ERK1/2), which are known to contribute to chronic pain, within these human neuromas.
Spec (examined) Gene_expression (expression) of ERK1 associated with lasting pain and neuroma
11) Confidence 0.58 Published 2008 Journal Ann. Neurol. Section Abstract Doc Link 19107992 Disease Relevance 0.62 Pain Relevance 1.21
We show that the expressions of TLR4, myeloid differentiation protein 88 (MyD88), nuclear factor (NF)-kappaB, phospho-IkappaB, phospho-extracellular signal-regulated kinases 1/2 (p-Erk1/2) and the inflammatory cytokines interleukin (IL)-8, tumor necrosis factor (TNF)-alpha and interferon (IFN)-beta were significantly increased in Acanthamoeba-treated cells.
Gene_expression (expressions) of Erk1 associated with necrosis, inflammation, cancer, meningoencephalitis and cytokine
12) Confidence 0.58 Published 2010 Journal Immunol. Cell Biol. Section Abstract Doc Link 20125114 Disease Relevance 1.23 Pain Relevance 0.25
This was accompanied by a decrease in the expressions of SOS and phosphorylated MAP kinases, ERK1 and ERK2, but not FAK or Grab2.
Gene_expression (expressions) of ERK1
13) Confidence 0.33 Published 2004 Journal Med. Sci. Monit. Section Body Doc Link 15173663 Disease Relevance 0 Pain Relevance 0
Apoptosis and cell cycle analysis is carried out by flow cytometry, the phosphorylation of mitogen-activated protein kinases (MAPK) ERK1 and ERK2 is detected by Western blotting assay, and changes of calcium concentration were analyzed using the calcium-sensitive dye Fluo-3 AM.
Gene_expression (detected) of ERK1 associated with apoptosis
14) Confidence 0.30 Published 2004 Journal Int. Immunopharmacol. Section Abstract Doc Link 14975362 Disease Relevance 0.60 Pain Relevance 0.61
We report here that deletion of the ERK1 isoform, which leads to increased ERK2 stimulus-dependent signaling, facilitates the development of cocaine-induced psychomotor sensitization and the acquisition of a cocaine conditioned place preference.
Gene_expression (deletion) of ERK1 associated with cocaine
15) Confidence 0.30 Published 2006 Journal Neuropsychopharmacology Section Abstract Doc Link 16407894 Disease Relevance 0.07 Pain Relevance 0.36
Levels of phosphorylated and total ERK1, ERK2 (p44 and p42, respectively), and p38 MAPK were measured in fibroblast-like cells from OA and RA patients, derived from the synovial tissue, by Western blotting.
Gene_expression (Levels) of ERK1 in fibroblast associated with rheumatoid arthritis and osteoarthritis
16) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 1.27 Pain Relevance 0.77
Treatment with A3AR agonist before reperfusion markedly increased ERK1 and ERK2 expression and attenuated reperfusion lung injury and apoptosis, thus presenting a promising approach for moderating lung injury and supporting recovery after clinical I/R.


Gene_expression (expression) of ERK1 in lung associated with lung injury, agonist and apoptosis
17) Confidence 0.27 Published 2007 Journal Crit Care Section Body Doc Link PMC2206506 Disease Relevance 1.39 Pain Relevance 0.30
For example, expression of cyclin F and ERK1 were down-regulated ?
Gene_expression (expression) of ERK1
18) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.19 Pain Relevance 0.07
PAR2 activation also unexpectedly down-regulated expression of MAPK associated genes, including ERK-1.
Gene_expression (expression) of ERK-1
19) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.29 Pain Relevance 0.03
Levels of total ERK1 and ERK2 were unaffected by the drug treatments (Figure 7a).
Gene_expression (Levels) of ERK1
20) Confidence 0.24 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453762 Disease Relevance 0.25 Pain Relevance 0.43

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox