INT71786

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Context Info
Confidence 0.82
First Reported 1997
Last Reported 2011
Negated 1
Speculated 6
Reported most in Abstract
Documents 256
Total Number 272
Disease Relevance 110.09
Pain Relevance 46.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
fibroblast 8
epithelial cells 6
myometrium 4
colon 4
upper 4
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 1832 100.00 Very High Very High Very High
Kinase C 30 100.00 Very High Very High Very High
agonist 819 99.86 Very High Very High Very High
Paracetamol 39 99.84 Very High Very High Very High
Dopamine 97 99.82 Very High Very High Very High
bradykinin 49 99.82 Very High Very High Very High
COX-2 inhibitor 47 99.78 Very High Very High Very High
Opioid 211 99.74 Very High Very High Very High
Cannabinoid 60 99.70 Very High Very High Very High
cytokine 2140 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Osteoarthritis 778 100.00 Very High Very High Very High
Stress 493 100.00 Very High Very High Very High
Cancer 1637 99.98 Very High Very High Very High
Neuroblastoma 585 99.84 Very High Very High Very High
Hepatocellular Cancer 133 99.84 Very High Very High Very High
Malignant Neoplastic Disease 314 99.68 Very High Very High Very High
Colon Cancer 669 99.64 Very High Very High Very High
Apoptosis 1603 99.62 Very High Very High Very High
Metaplasia 168 99.56 Very High Very High Very High
Rheumatoid Arthritis 2077 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both the sulfide and sulfone metabolites of sulindac as well as more potent cyclic GMP-dependent phosphodiesterase inhibitors were shown to cause inhibition of extracellular signal-regulated kinase (ERK)1/2 phosphorylation at doses (40-600 microM) and times (1-5 days) consistent with the induction of apoptosis by the drugs.
Phosphorylation (phosphorylation) of ERK associated with apoptosis
1) Confidence 0.82 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11245463 Disease Relevance 0.93 Pain Relevance 0.19
EGF-stimulated phosphorylation of ERK and Bad is blocked by pretreatment with U0126, a selective MAP kinase kinase (MKK)1/2 inhibitor.
Phosphorylation (phosphorylation) of ERK
2) Confidence 0.80 Published 2003 Journal Cancer Res. Section Abstract Doc Link 12566304 Disease Relevance 1.32 Pain Relevance 0.16
Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.
Phosphorylation (phosphorylation) of extracellular-regulated kinase in colon associated with colon cancer
3) Confidence 0.80 Published 2003 Journal Cancer Res. Section Title Doc Link 12566304 Disease Relevance 1.43 Pain Relevance 0.17
Subsequently, rapid phosphorylation of ERK1/2 by MCC-555 treatment was detected.
Phosphorylation (phosphorylation) of ERK
4) Confidence 0.80 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731769 Disease Relevance 0.59 Pain Relevance 0.06
Moreover, in vitro studies in Panc-1 cells show that activation of VEGFR1 by VEGFB to increase mitogen-activated protein kinase 1/2 phosphorylation and cell migration on collagen-coated plates is also inhibited by tolfenamic acid.
Phosphorylation (phosphorylation) of mitogen-activated protein kinase 1
5) Confidence 0.80 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17409437 Disease Relevance 0.57 Pain Relevance 0.07
Treatment of carcinoid tumor cells with ZM336372 resulted in progressive phosphorylation of Raf-1, mitogen-activated protein kinase 1/2, and extracellular signal-regulated kinase 1/2.
Phosphorylation (phosphorylation) of mitogen-activated protein kinase 1 associated with carcinoid
6) Confidence 0.80 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15956248 Disease Relevance 0.98 Pain Relevance 0.06
BK treatment resulted in the phosphorylation of p38 MAPK and extracellular signal-regulated kinase (ERK)1/2, and 2-APB could suppress BK-induced phosphorylation of ERK1/2.
Phosphorylation (phosphorylation) of ERK associated with bradykinin
7) Confidence 0.80 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15345332 Disease Relevance 0.31 Pain Relevance 0.55
Gabapentin (120 and 240 microM) also concentration-dependently inhibited collagen (1 microg mL(-1))-induced phosphoinositide breakdown, intracellular Ca(2+) mobilization, thromboxane A(2) formation, and p38 MAPK phosphorylation in human platelets.
Phosphorylation (phosphorylation) of p38 in platelets associated with gabapentin
8) Confidence 0.80 Published 2007 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 17883897 Disease Relevance 0.08 Pain Relevance 0.74
These results suggest that the inhibition of ERK1/2 phosphorylation is responsible for at least part of the induction of programmed cell death by sulindac metabolites.
Phosphorylation (phosphorylation) of ERK associated with apoptosis
9) Confidence 0.79 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11245463 Disease Relevance 0.92 Pain Relevance 0.13
When compared with control HT29-pCEP4 clones, HT29-MEK1(R4F) clones were resistant to both apoptosis and inhibition of ERK1/2 phosphorylation induced by sulindac metabolites.
Phosphorylation (phosphorylation) of ERK associated with apoptosis
10) Confidence 0.79 Published 2004 Journal Cancer Res. Section Abstract Doc Link 15548677 Disease Relevance 1.11 Pain Relevance 0.11
These results suggest that ARE sequences in the 3'UTR of the NAG-1 gene contribute to mRNA degradation and ERK1/2 phosphorylation is responsible for the stabilization of NAG-1 mRNA.
Phosphorylation (phosphorylation) of ERK
11) Confidence 0.79 Published 2006 Journal Mol. Cancer Ther. Section Abstract Doc Link 16731769 Disease Relevance 0.38 Pain Relevance 0.05
In conclusion, our study showed that growth inhibitory concentrations of selective COX-1 and COX-2 inhibitors increased ERK1/2 phosphorylation in hepatoma cells, and that inhibition of the MEK/ERK signaling pathway potentiates the antitumor activity of both types of inhibitors.
Phosphorylation (phosphorylation) of ERK associated with hepatocellular cancer and cox-2 inhibitor
12) Confidence 0.79 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.67 Pain Relevance 0.37
Aspirin and NS-398, in contrast to PD98059, did not suppress ERK1/2 phosphorylation induced by HGF.
Phosphorylation (phosphorylation) of ERK in HGF associated with aspirin
13) Confidence 0.79 Published 2002 Journal Hepatology Section Abstract Doc Link 11981761 Disease Relevance 0.49 Pain Relevance 0.48
The decreased phosphorylation of extracellular signal-regulated kinase (ERK) was induced by JEV infection and the decrease in ERK was reversed by salicylate.
Phosphorylation (phosphorylation) of extracellular signal-regulated kinase associated with infection
14) Confidence 0.78 Published 2002 Journal J. Gen. Virol. Section Abstract Doc Link 12124453 Disease Relevance 0.75 Pain Relevance 0.58
The decreased phosphorylation of extracellular signal-regulated kinase (ERK) was induced by JEV infection and the decrease in ERK was reversed by salicylate.
Phosphorylation (phosphorylation) of ERK associated with infection
15) Confidence 0.78 Published 2002 Journal J. Gen. Virol. Section Abstract Doc Link 12124453 Disease Relevance 0.75 Pain Relevance 0.58
Growth inhibitory concentrations of NSAIDs unexpectedly increased ERK phosphorylation in BxPC-3 and MIA PaCa-2 cells.
Phosphorylation (phosphorylation) of ERK in BxPC-3
16) Confidence 0.77 Published 2003 Journal Pancreas Section Body Doc Link 14576498 Disease Relevance 0.15 Pain Relevance 0
In addition, methionine enkephalin also elevates the levels of protein kinase C (PKC) activity and phosphorylated extracellular signal-regulated kinase (ERK) 1/2.
Phosphorylation (phosphorylated) of ERK associated with kinase c and enkephalin
17) Confidence 0.77 Published 2004 Journal Int. Immunopharmacol. Section Abstract Doc Link 14975362 Disease Relevance 0.32 Pain Relevance 0.79
Apoptosis and cell cycle analysis is carried out by flow cytometry, the phosphorylation of mitogen-activated protein kinases (MAPK) ERK1 and ERK2 is detected by Western blotting assay, and changes of calcium concentration were analyzed using the calcium-sensitive dye Fluo-3 AM.
Spec (analyzed) Phosphorylation (phosphorylation) of ERK2 associated with apoptosis
18) Confidence 0.77 Published 2004 Journal Int. Immunopharmacol. Section Abstract Doc Link 14975362 Disease Relevance 0.61 Pain Relevance 0.62
In addition, methionine enkephalin also elevates the levels of protein kinase C (PKC) activity and phosphorylated extracellular signal-regulated kinase (ERK) 1/2.
Phosphorylation (phosphorylated) of extracellular signal-regulated kinase associated with kinase c and enkephalin
19) Confidence 0.77 Published 2004 Journal Int. Immunopharmacol. Section Abstract Doc Link 14975362 Disease Relevance 0.32 Pain Relevance 0.79
Both the sulfide and sulfone metabolites of sulindac as well as more potent cyclic GMP-dependent phosphodiesterase inhibitors were shown to cause inhibition of extracellular signal-regulated kinase (ERK)1/2 phosphorylation at doses (40-600 microM) and times (1-5 days) consistent with the induction of apoptosis by the drugs.
Phosphorylation (phosphorylation) of signal-regulated kinase associated with apoptosis
20) Confidence 0.72 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11245463 Disease Relevance 0.93 Pain Relevance 0.19

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