INT71787

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 37
Total Number 44
Disease Relevance 17.50
Pain Relevance 17.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK3) mitochondrion (MAPK3) Golgi apparatus (MAPK3)
protein complex assembly (MAPK3) protein complex (MAPK3) cytoplasm (MAPK3)
Anatomy Link Frequency
spinal cord 3
HEK 2
colon 1
fibroblast 1
DRG 1
MAPK3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 24 99.88 Very High Very High Very High
fluoxetine 15 99.82 Very High Very High Very High
Opioid 32 99.80 Very High Very High Very High
mu opioid receptor 2 99.66 Very High Very High Very High
COX-2 inhibitor 15 99.38 Very High Very High Very High
dorsal root ganglion 4 99.24 Very High Very High Very High
dexamethasone 1 99.12 Very High Very High Very High
Kappa opioid receptor 10 99.10 Very High Very High Very High
Spinal cord 18 98.98 Very High Very High Very High
Lasting pain 4 98.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 287 99.76 Very High Very High Very High
Hepatocellular Cancer 16 99.76 Very High Very High Very High
Colon Cancer 277 99.70 Very High Very High Very High
Urological Neuroanatomy 5 99.64 Very High Very High Very High
Pain 43 98.92 Very High Very High Very High
Ganglion Cysts 4 98.76 Very High Very High Very High
INFLAMMATION 120 98.54 Very High Very High Very High
Apoptosis 193 97.70 Very High Very High Very High
Neuroma 20 97.60 Very High Very High Very High
Nociception 9 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, tumor cells with elevated ERK1/2 activity can be effectively sensitized to radiation treatment by a combinational inhibition of HSP90 and MAPK activity.
Positive_regulation (elevated) of ERK1 associated with cancer
1) Confidence 0.67 Published 2005 Journal Oncogene Section Abstract Doc Link 15735687 Disease Relevance 0.23 Pain Relevance 0
We hypothesized that activation of extracellular signal-regulated kinases 1 and 2 (ERK1/2) and the expression of c-Fos, prodynorphin (mRNA), and dynorphin in the spinal cord could participate in the molecular mechanisms underlying postoperative opioid-induced sensitization.
Positive_regulation (activation) of ERK1 in spinal cord associated with dynorphin, opioid and spinal cord
2) Confidence 0.67 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 19917879 Disease Relevance 0.26 Pain Relevance 0.90
Furthermore, fluoxetine-induced activation of both the cAMP-response element-binding (CREB) protein and extracellular signal-regulated protein kinases (ERK1/2), which was abolished by the selective inhibitor of MAP kinase kinase (MEK) 1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene (U0126), and increased cyclin D1 expression.
Positive_regulation (activation) of ERK1 associated with fluoxetine
3) Confidence 0.67 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18573488 Disease Relevance 0 Pain Relevance 1.17
Recently, we have reported that the phosphorylation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) and p38 mitogen-activated protein kinase (MAPK) occurs in primary afferent neurons in response to noxious stimulation of the peripheral tissue, i.e., activity-dependent activation of ERK1/2 and p38 MAPK in dorsal root ganglion (DRG) neurons.
Positive_regulation (activation) of ERK1 in DRG associated with ganglion cysts and dorsal root ganglion
4) Confidence 0.67 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17237256 Disease Relevance 0.68 Pain Relevance 0.50
Regarding the selectivity of KDN21 for phenotypic delta and kappa opioid receptors, we investigated the effect of KDN21 on the activation of MAPKs [extracellular signal-regulated kinases 1 and 2 (ERK1/2)] by delta- or kappa-selective agonists.
Spec (investigated) Positive_regulation (activation) of ERK1 associated with agonist and kappa opioid receptor
5) Confidence 0.67 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16006595 Disease Relevance 0 Pain Relevance 0.57
FGF-2 rapidly induced activation of ERK1/2 and p38 MAP kinases, and specific inhibitors for these enzymes significantly reduced FGF-2-induced IL-6 release.
Positive_regulation (activation) of ERK1
6) Confidence 0.67 Published 2004 Journal Pancreas Section Body Doc Link 15502643 Disease Relevance 0 Pain Relevance 0
Acute opioid treatment of HEK 293 cells expressing mu-opioid receptors resulted in the activation of ERK1/2, and this response was abolished in the presence of U0126, a MEK1/2 inhibitor.
Positive_regulation (activation) of ERK1 in HEK associated with mu opioid receptor and opioid
7) Confidence 0.67 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11720767 Disease Relevance 0 Pain Relevance 0.70
Both Gi and Gz mediated DPDPE-induced activation of ERK1/2, but these responses were abolished by chronic opioid treatment.
Positive_regulation (activation) of ERK1 associated with opioid
8) Confidence 0.67 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0.05 Pain Relevance 0.65
Collectively, our results show that although Gz mediated opioid-induced inhibition of adenylyl cyclase and activation of ERK1/2, Gz alone was insufficient to mediate opioid-induced adenylyl cyclase supersensitization.
Positive_regulation (activation) of ERK1 associated with opioid
9) Confidence 0.67 Published 2000 Journal J. Neurochem. Section Abstract Doc Link 10737627 Disease Relevance 0 Pain Relevance 0.57
These findings suggest that activated ERK1/2 could induce c-Fos expression and trigger the transcription of prodynorphin in the spinal cord.
Positive_regulation (activated) of ERK1 in spinal cord associated with spinal cord
10) Confidence 0.67 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 19917879 Disease Relevance 0.20 Pain Relevance 1.08
Again in PFCX, FLX selectively increased the expression level of MAP kinases Erk1/2, without affecting their phosphorylation.
Positive_regulation (increased) of Erk1 in PFCX associated with urological neuroanatomy and fluoxetine
11) Confidence 0.49 Published 2004 Journal Neuropsychopharmacology Section Abstract Doc Link 15138445 Disease Relevance 0.40 Pain Relevance 0.62
Despite a complete blockade of ERK1/2 phosphorylation, U0126 did not affect opioid-induced AC superactivation, indicating that ERK1/2 activity was not required for opioid-induced AC superactivation in HEK 293 cells.
Neg (not) Positive_regulation (required) of ERK1 in HEK associated with opioid
12) Confidence 0.49 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11720767 Disease Relevance 0 Pain Relevance 0.69
Both CAP and WIN induced transient increases in Erk1/2, p38, JNK1/2 MAPK and Akt/PI-3K phosphorylation status resulting in cell proliferation and migration increases which mirrored those elicited by EGF.
Positive_regulation (increases) of Erk1
13) Confidence 0.49 Published 2010 Journal Exp. Eye Res. Section Abstract Doc Link 20619260 Disease Relevance 0.15 Pain Relevance 0.63
Treatment with COX-1 and COX-2 inhibitors in the presence of the selective MEK1/2 inhibitor U0126 effectively suppressed ERK1/2 activation and combinations of either SC-560 or CAY10404 with U0126 resulted in synergistic effects on cell growth inhibition and induction of apoptosis.
Positive_regulation (activation) of ERK1 associated with cox-2 inhibitor and apoptosis
14) Confidence 0.49 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.78 Pain Relevance 0.48
Treatment of hepatoma cells with the selective COX-1 inhibitor SC-560, as well as with the selective COX-2 inhibitor CAY10404, was associated with activation of ERK1/2 in a time- and dose-dependent manner.
Positive_regulation (activation) of ERK1 associated with hepatocellular cancer and cox-2 inhibitor
15) Confidence 0.49 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 18424914 Disease Relevance 0.72 Pain Relevance 0.49
We also identified an early expression of c-Fos immunoreactivity in the superficial laminae of the dorsal horn of the spinal cord (peak at 4 h; p < 0.001), together with a partial activation of ERK1/2 (4 h; p < 0.001).
Spec (partial) Positive_regulation (activation) of ERK1 in spinal cord associated with dorsal horn and spinal cord
16) Confidence 0.49 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 19917879 Disease Relevance 0.21 Pain Relevance 1.09
Pretreatment of MAPK inhibitors (PD98059 and SB203580) markedly blocked Ca(2+)-induced IL-8 production from cells, and anti-inflammatory drugs, such as dexamethasone and cyclosporin A, partially inhibited the activation of ERK1/2.
Positive_regulation (activation) of ERK1 associated with inflammation, cinod and dexamethasone
17) Confidence 0.49 Published 2005 Journal Cytokine Section Abstract Doc Link 16343928 Disease Relevance 0.16 Pain Relevance 0.21
Due to the beneficial effect of sorafenib in HCC and strong activation of EGFR, ERK1 and AKT1, our patient received sorafenib.
Positive_regulation (activation) of ERK1 associated with hepatocellular cancer
18) Confidence 0.48 Published 2010 Journal Onkologie Section Abstract Doc Link 20502062 Disease Relevance 1.14 Pain Relevance 0.09
We have compared the activation of G protein, inhibition of adenylyl cyclase, stimulation of intracellular calcium release, and activation of the ERK1/2 MAPK pathway between cells expressing mutant Galpha(o) that is either RGS-insensitive or RGS-sensitive.
Positive_regulation (activation) of ERK1
19) Confidence 0.45 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12524446 Disease Relevance 0.19 Pain Relevance 0.52
We also examined the expression of two mitogen-activated protein (MAP) kinases, activated p38 and extracellular signal-regulated kinases 1 and 2 (ERK1/2), which are known to contribute to chronic pain, within these human neuromas.
Positive_regulation (activated) of ERK1 associated with lasting pain and neuroma
20) Confidence 0.45 Published 2008 Journal Ann. Neurol. Section Abstract Doc Link 19107992 Disease Relevance 0.61 Pain Relevance 1.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox