INT71788

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.90
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAP3K1) cytoskeleton (MAP3K1) cytoplasm (MAP3K1)
Anatomy Link Frequency
TK-1 1
cleavage 1
salivary gland 1
MAP3K1 (Homo sapiens)
MAP3K1 - C1238V (1)
Pain Link Frequency Relevance Heat
Morphine 8 99.54 Very High Very High Very High
positron emission tomography 48 97.68 Very High Very High Very High
interstitial cystitis 8 95.62 Very High Very High Very High
narcan 1 89.44 High High
imagery 37 88.24 High High
antagonist 1 87.76 High High
opioid receptor 1 82.00 Quite High
Kinase C 1 34.56 Quite Low
cva 2 32.40 Quite Low
peripheral neuropathy 5 12.16 Low Low
Disease Link Frequency Relevance Heat
Carcinoma 94 98.60 Very High Very High Very High
Skin Cancer 28 98.32 Very High Very High Very High
Shock 43 97.00 Very High Very High Very High
Cancer 153 96.44 Very High Very High Very High
Lung Cancer 10 96.32 Very High Very High Very High
Interstitial Cystitis 8 95.62 Very High Very High Very High
Non-small-cell Lung Cancer 17 95.20 Very High Very High Very High
Mastocytoma 1 93.00 High High
Osteogenic Sarcomas 1 92.32 High High
Stress 75 92.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CBD-tagged wild type MEKK1 or the C1238V mutant were expressed in cells, purified on chitin beads and then treated with PEITC in vitro.
Gene_expression (expressed) of MEKK1
1) Confidence 0.70 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.20 Pain Relevance 0
As before, wild type MEKK1 but not C1238V MEKK1 was inhibited in vitro by Bio-ITC (lanes 4 and 7, middle panel), and wild type MEKK1 (but not C1238V MEKK1) was covalently labeled with Bio-ITC (lanes 4 and 7, top panel).
Gene_expression (labeled) of MEKK1 (C1238V)
2) Confidence 0.61 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.20 Pain Relevance 0
MEKK1 is protected from PEITC inhibition by an ATP analog
Gene_expression (protected) of MEKK1
3) Confidence 0.61 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.06 Pain Relevance 0
As before, wild type MEKK1 but not C1238V MEKK1 was inhibited in vitro by Bio-ITC (lanes 4 and 7, middle panel), and wild type MEKK1 (but not C1238V MEKK1) was covalently labeled with Bio-ITC (lanes 4 and 7, top panel).
Gene_expression (labeled) of MEKK1
4) Confidence 0.61 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.20 Pain Relevance 0
To determine the effect of isothiocyanates on MEKK1 activity, we expressed a full-length MEKK1 protein fused to a chitin binding domain (CBD) tag to allow purification of the protein by binding to chitin beads.
Gene_expression (expressed) of MEKK1
5) Confidence 0.54 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.17 Pain Relevance 0
These cells were chosen because they have relatively high expression of MEKK1 in comparison to other cell lines, allowing detection of the endogenous protein activity by immunoprecipitation and in vitro kinase assay.
Gene_expression (expression) of MEKK1
6) Confidence 0.54 Published 2007 Journal BMC Cancer Section Body Doc Link PMC2071920 Disease Relevance 0.33 Pain Relevance 0
The activity of MEKK1 expressed in cells was monitored using in vitro kinase assays to measure changes in catalytic activity.
Gene_expression (expressed) of MEKK1
7) Confidence 0.54 Published 2007 Journal BMC Cancer Section Abstract Doc Link PMC2071920 Disease Relevance 0.16 Pain Relevance 0
Morphine enhanced the cellular levels of ERK1 (44 kDa), ERK2 (42 kDa), a 54-kDa ERK, MEK1 (45 kDa), and MEKK (78 kDa).
Gene_expression (levels) of MEKK associated with morphine
8) Confidence 0.53 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9341110 Disease Relevance 0 Pain Relevance 0.82
Calcitriol promotes the expression of mitogen-activated protein kinase kinase kinase (MEKK-1) and the cleavage of caspase 3 when used in combination with cisplatin in SCC cells 18.
Gene_expression (expression) of MEKK-1 in cleavage associated with skin cancer
9) Confidence 0.11 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 2.03 Pain Relevance 0
The general pattern of gene expression in IC and APF-treated cells suggested a less proliferative phenotype, with increased expression of E-cadherin, phosphoribosylpyrophosphate synthetase-associated protein 39, and SWI/SNF complex 170-kDa subunit, and decreased expression of vimentin, alpha2-integrin, alpha1-catenin, cyclin D1, and jun N-terminal kinase 1; these findings were confirmed for the structural gene products (E-cadherin, vimentin, alpha2-integrin, and alpha-catenin) by immunohistochemistry.
Gene_expression (expression) of kinase 1 associated with interstitial cystitis
10) Confidence 0.07 Published 2003 Journal Physiol. Genomics Section Abstract Doc Link 12847144 Disease Relevance 0.58 Pain Relevance 0.58
TK-1: thymidine kinase-1
Gene_expression (thymidine) of kinase-1 in TK-1
11) Confidence 0.04 Published 2007 Journal BMC Nucl Med Section Body Doc Link PMC1931583 Disease Relevance 0.26 Pain Relevance 0.27
2M), phosphoglycerate kinase 1 (PGK1), succinate dehydrogenase complex subunit A (SDHA), hypoxanthine-guanine phosphoribosyltransferase (HPRT), and ribosomal protein L13 (RPL13) genes, and expressed in terms of arbitrary units (a.u.).

2.5.

Gene_expression (expressed) of kinase 1
12) Confidence 0.02 Published 2010 Journal Journal of Nucleic Acids Section Body Doc Link PMC2911612 Disease Relevance 0 Pain Relevance 0
Overexpression of sphingosine kinase 1 is associated with salivary gland carcinoma progression and might be a novel predictive marker for adjuvant therapy

Background

Gene_expression (Overexpression) of kinase 1 in salivary gland associated with carcinoma
13) Confidence 0.01 Published 2010 Journal BMC Cancer Section Title Doc Link PMC2949806 Disease Relevance 0.72 Pain Relevance 0

General Comments

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