INT71789

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Context Info
Confidence 0.70
First Reported 1997
Last Reported 2011
Negated 11
Speculated 5
Reported most in Abstract
Documents 396
Total Number 440
Disease Relevance 234.44
Pain Relevance 89.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (MAPK1) mitochondrion (MAPK1) Golgi apparatus (MAPK1)
DNA binding (MAPK1) protein complex (MAPK1) response to stress (MAPK1)
Anatomy Link Frequency
fibroblasts 44
epithelial cells 21
Caco-2 10
T cells 7
myometrium 6
MAPK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 4160 100.00 Very High Very High Very High
Inflammation 3599 100.00 Very High Very High Very High
cytokine 2782 100.00 Very High Very High Very High
Osteoarthritis 1360 100.00 Very High Very High Very High
cINOD 420 100.00 Very High Very High Very High
dexamethasone 69 100.00 Very High Very High Very High
Kinase C 60 100.00 Very High Very High Very High
aspirin 68 99.98 Very High Very High Very High
Nicotine 206 99.90 Very High Very High Very High
Inflammatory stimuli 94 99.90 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 6105 100.00 Very High Very High Very High
INFLAMMATION 4140 100.00 Very High Very High Very High
Down Syndrome 864 100.00 Very High Very High Very High
Osteoarthritis 665 100.00 Very High Very High Very High
Lung Cancer 278 100.00 Very High Very High Very High
Infection 960 99.98 Very High Very High Very High
Shock 132 99.98 Very High Very High Very High
Apoptosis 2910 99.92 Very High Very High Very High
Skin Cancer 57 99.90 Very High Very High Very High
Cancer 2164 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taurine was also shown to stimulate the activation of ERK 1/2.
Positive_regulation (activation) of ERK
1) Confidence 0.70 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 18036343 Disease Relevance 0.26 Pain Relevance 0.10
This taurine-stimulated ERK 1/2 activation was inhibited by PD98059.
Positive_regulation (activation) of ERK
2) Confidence 0.70 Published 2007 Journal FEBS Lett. Section Abstract Doc Link 18036343 Disease Relevance 0.26 Pain Relevance 0.10
In the present work, we tested the hypothesis that serotonin (5-hydroxytryptamine = 5-HT) might activate the extracellular signal-regulated kinase (ERK) pathway in human peripheral blood mononuclear cells (PBMC).
Spec (might) Positive_regulation (activate) of ERK in PBMC associated with serotonin
3) Confidence 0.69 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.05
In addition, p38 MAP kinase was not activated under these conditions.
Neg (not) Positive_regulation (activated) of p38
4) Confidence 0.69 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.21
This activation of ERK did not occur in adherent monocytes suggesting that the effect was on lymphocytes.
Positive_regulation (activation) of ERK in monocytes
5) Confidence 0.69 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.19
Our results showed an increase in ERK activation by 5-HT with a peak effect at 30 min and maximal stimulation with 5-HT at 1microM.
Positive_regulation (activation) of ERK
6) Confidence 0.69 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.11
In the present work, we tested the hypothesis that serotonin (5-hydroxytryptamine = 5-HT) might activate the extracellular signal-regulated kinase (ERK) pathway in human peripheral blood mononuclear cells (PBMC).
Spec (might) Positive_regulation (activate) of extracellular signal-regulated kinase in PBMC associated with serotonin
7) Confidence 0.69 Published 2004 Journal Life Sci. Section Abstract Doc Link 15530505 Disease Relevance 0 Pain Relevance 0.05
Furthermore, treatment with 3MA markedly down-regulated capsaicin-induced p38 activation and LC3 conversion, and BaF1 completely down-regulated ERK activation and led to LC3II accumulation.
Positive_regulation (activation) of p38 associated with qutenza
8) Confidence 0.68 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.61 Pain Relevance 0.74
In MCF-7 and MDA-MB-231 cells, p38 was activated for more than 48 h by capsaicin treatment, but extracellular signal-regulated kinase (ERK) activation decreased after 12 h, and LC3II levels continuously increased.
Positive_regulation (activated) of p38 in MDA-MB-231 associated with qutenza
9) Confidence 0.68 Published 2010 Journal Mol. Pharmacol. Section Abstract Doc Link 20371669 Disease Relevance 0.65 Pain Relevance 0.63
Taken together, these data demonstrate for the first time that the EP2 receptor mediates the mitogenic effect of PGE(2) in esophageal squamous cell carcinoma via activation of the Erk/AP-1 pathway.
Positive_regulation (activation) of Erk associated with skin cancer
10) Confidence 0.67 Published 2008 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 18583546 Disease Relevance 0.17 Pain Relevance 0.07
Together, our findings provide a unifying mechanism for pain hypersensitivity after peripheral nerve injury through P2X4R-evoked increase in Ca(2+) and activation of p38-MAPK leading to the synthesis and exocytotic release of BDNF from microglia.
Positive_regulation (activation) of p38 in microglia associated with nervous system injury, hypersensitivity, stimulus evoked pain and peripheral nerve injury
11) Confidence 0.67 Published 2009 Journal J. Neurosci. Section Abstract Doc Link 19295157 Disease Relevance 0.30 Pain Relevance 0.15
Sulindac sulfide treatment was associated with activation of ERKp44/42 and p38 MAPK in a dosage- and time-dependent manner, and also activated upstream MEK.
Positive_regulation (activation) of ERK
12) Confidence 0.67 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15657353 Disease Relevance 0.82 Pain Relevance 0.26
In conclusion, MEK/ERK and p38 MAPK activation mediate COX-2 induction by sulindac sulfide.
Positive_regulation (activation) of ERK
13) Confidence 0.67 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15657353 Disease Relevance 0.68 Pain Relevance 0.33
U0126 dose-dependently protected HT29 cells from these antiproliferative effects of NS-398, indicating an antiproliferative role for sustained ERK-1/-2 activation in response to this NSAID.
Positive_regulation (activation) of ERK associated with cinod
14) Confidence 0.67 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.50 Pain Relevance 0.26
Treatment of HT29 colorectal carcinoma cells with 75 microM NS-398 caused activation of ERK-1/-2 but not of the p38 and c-Jun N-terminal kinase (JNK) mitogen-activated protein kinases.
Positive_regulation (activation) of ERK associated with colorectal cancer
15) Confidence 0.67 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.64 Pain Relevance 0.15
The activation of ERK by NS-398 preceded and accompanied a decrease in attached cell yield and an increase in apoptosis.
Positive_regulation (activation) of ERK associated with apoptosis
16) Confidence 0.67 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.60 Pain Relevance 0.28
U0126, a specific inhibitor of the ERK-activating kinases MEK-1/-2, prevented the activation of ERK induced by NS-398 and blocked the increase in COX-2 protein expression seen when HT29 cells were treated with NS-398 alone.
Positive_regulation (induced) of ERK
17) Confidence 0.67 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 11992399 Disease Relevance 0.61 Pain Relevance 0.26
On the other hand, activation of p38 MAPK in EoL-1 cells by NaSal could lead to apoptosis.
Positive_regulation (activation) of p38 associated with apoptosis
18) Confidence 0.66 Published 1999 Journal Immunol. Invest. Section Abstract Doc Link 10574634 Disease Relevance 0.78 Pain Relevance 0.52
Results demonstrated that all three cytokines could trigger the receptor-mediated activation of extracellular signal-regulated kinase (ERK) within one hour but not p38 MAPK activity in EoL-1 cells.
Positive_regulation (activation) of extracellular signal-regulated kinase associated with cytokine
19) Confidence 0.66 Published 1999 Journal Immunol. Invest. Section Abstract Doc Link 10574634 Disease Relevance 0.74 Pain Relevance 0.38
In contrast, sodium salicylate (NaSal), a nonsteroidal anti-inflammatory drug (NSAID), could activate p38 MAPK but not ERK within one hour.
Neg (not) Positive_regulation (activate) of ERK associated with inflammation and cinod
20) Confidence 0.66 Published 1999 Journal Immunol. Invest. Section Abstract Doc Link 10574634 Disease Relevance 0.82 Pain Relevance 0.41

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