INT71794

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Context Info
Confidence 0.39
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 18
Disease Relevance 10.50
Pain Relevance 2.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINC1) extracellular region (SERPINC1) plasma membrane (SERPINC1)
Anatomy Link Frequency
blood 1
endothelial cells 1
blood vessels 1
liver 1
SERPINC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 13 100.00 Very High Very High Very High
cva 119 99.36 Very High Very High Very High
Nicotine 3 97.44 Very High Very High Very High
Inflammation 256 97.24 Very High Very High Very High
Angina 1 95.52 Very High Very High Very High
fortral 1 92.72 High High
Central nervous system 22 90.48 High High
Paracetamol 2 86.68 High High
alcohol 3 86.20 High High
antagonist 4 83.68 Quite High
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 3 100.00 Very High Very High Very High
Pulmonary Embolism 15 99.76 Very High Very High Very High
Liver Failure 2 99.68 Very High Very High Very High
Sepsis 308 99.56 Very High Very High Very High
Thrombosis 60 99.54 Very High Very High Very High
Thrombophilia 9 99.26 Very High Very High Very High
Increased Venous Pressure Under Development 2 99.04 Very High Very High Very High
Nicotine Addiction 19 98.88 Very High Very High Very High
Amyloidosis 42 98.44 Very High Very High Very High
Disseminated Intravascular Coagulation 409 97.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because, according to subgroup analysis, antithrombin reduced 90-day mortality only in the group of patients who did not receive heparin at the same time, an interaction between antithrombin and heparin was postulated that probably offset the beneficial anti-inflammatory properties of the former [19,57,58].
antithrombin Binding (interaction) of associated with inflammation
1) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.69 Pain Relevance 0.09
Therapeutic doses of heparin were not permitted because of the interaction of this agent with antithrombin and its anticoagulatory effects.
antithrombin Binding (interaction) of
2) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.69 Pain Relevance 0
Because the possibility of an interaction with antithrombin had not been excluded, the subgroup analysis was determined a priori, before the start of the study, although there was no stratification for heparin.
antithrombin Binding (interaction) of
3) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.48 Pain Relevance 0.08
It has been estimated that there are about 500,000 binding sites for antithrombin on each single endothelial cell on the inner surface of the blood vessels [26].
antithrombin Binding (binding) of in blood vessels
4) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.13 Pain Relevance 0.03
Interaction between antithrombin and heparin
antithrombin Binding (Interaction) of
5) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.50 Pain Relevance 0.25
Results of preclinical research carried out after the KyberSept study suggested the possibility of an undesirable drug interaction between antithrombin and heparin, and this – together with previous knowledge on this subject – provided the justification for re-analyses of the findings.
antithrombin Binding (interaction) of
6) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.65 Pain Relevance 0.10
[Congenital antithrombin III deficiency associated with pulmonary thromboembolism].
antithrombin III Binding (associated) of associated with pulmonary embolism and cva
7) Confidence 0.37 Published 1997 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Title Doc Link 9341285 Disease Relevance 0.46 Pain Relevance 0.19
Most were also investigated with electrocardiograms, ultrasound of the precerebral vessels and cerebral magnetic resonance imaging (MRI), as well as extensive blood chemistry screening for coagulation parameters, hemoglobin (Hb), platelet count, erythrocyte sedimentation rate (ESR), activated partial thromboplastin time (APPT), fibrinogen, protein S and C, lupus anticoagulant and anticardiolipin antibodies, homocystein and antithrombin 3.
antithrombin 3 Binding (investigated) of in blood associated with systemic lupus erythematosus and imagery
8) Confidence 0.36 Published 2007 Journal BMC Med Section Body Doc Link PMC1939710 Disease Relevance 0.38 Pain Relevance 0.52
Heparin exerts an anticoagulatory effect by binding to antithrombin and thereby alters its conformation in such a manner that it inhibits thrombin 1000-fold more strongly [23].
antithrombin Binding (binding) of
9) Confidence 0.29 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.07 Pain Relevance 0.04
Further, rather less direct confirmation of the role of heparin as an unfavourable interaction partner with antithrombin in severe sepsis comes from another predefined subgroup analysis of the KyberSept trial.
antithrombin Binding (interaction) of associated with sepsis
10) Confidence 0.29 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.42 Pain Relevance 0.05
Interaction between antithrombin and heparin was considered a possible reason, because antithrombin achieved a significant reduction in mortality at 90 days in a subgroup of patients who did not simultaneously receive prophylactic doses of heparin.
antithrombin Binding (Interaction) of
11) Confidence 0.29 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.46 Pain Relevance 0
Antithrombin reduced the ischaemia/reperfusion induced renal or hepatic injury by inhibiting leucocyte activation, suggesting that therapeutic effects of antithrombin might be mainly mediated by prostacyclin released from endothelial cells through interaction of antithrombin with cell surface glycosaminoglycans [39,40].
antithrombin Spec (might) Binding (interaction) of in endothelial cells associated with injury and cv unclassified under development
12) Confidence 0.29 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.40 Pain Relevance 0.04
The mechanisms of such inhibitory interaction of porins with antithrombin remain to be detailed; however, antithrombin's heparin-binding site may well be among the potential targets because affinity of porins to heparin-binding domains of matrix proteins was recently reported [75].
antithrombin Binding (interaction) of
13) Confidence 0.29 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.51 Pain Relevance 0.03
Cigarette smoking results in faster clearance of heparin, possibly related to smoking-related activation of thrombosis with enhanced heparin binding to antithrombin III.
antithrombin III Binding (binding) of associated with nicotine addiction and thrombosis
14) Confidence 0.29 Published 1999 Journal Clin Pharmacokinet Section Abstract Doc Link 10427467 Disease Relevance 1.04 Pain Relevance 0.39
A transient hypercoagulable state due to liver failure is documented, characterized by acquired deficiencies of antithrombin III, protein C, and protein S.
antithrombin III Binding (characterized) of in liver associated with liver failure and thrombophilia
15) Confidence 0.29 Published 2007 Journal Vasc Endovascular Surg Section Abstract Doc Link 17704344 Disease Relevance 0.87 Pain Relevance 0.28
The activity of LMWHs is mediated by their binding to antithrombin III (AT III); however, because of fragmentation, the coagulation factors IIa and Xa are affected differently by AT III and, therefore, the antithrombotic activity is separated by the anticoagulant effect because of a larger anti-Xa activity compared with anti-IIa activity.
antithrombin III Binding (binding) of
16) Confidence 0.18 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605328 Disease Relevance 0.08 Pain Relevance 0.04
Recently, impairment of the thrombin-antithrombin pathway, in association with the low antithrombin biological activity was recognized to have possible pathogenic role in hypercoagulability of amyloidosis patients [10].
antithrombin Binding (recognized) of associated with amyloidosis and thrombophilia
17) Confidence 0.04 Published 2005 Journal Int Semin Surg Oncol Section Body Doc Link PMC1232862 Disease Relevance 2.45 Pain Relevance 0.38
In present medical practice the natural thrombin inhibitor – heparin and its low-molecular fragments are widely used, which act by formation of the triple complex with thrombin and antithrombin III– as anticoagulants of direct action (Mousa SA.
antithrombin Binding (complex) of
18) Confidence 0.01 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2627521 Disease Relevance 0.23 Pain Relevance 0.14

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