INT7180

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Context Info
Confidence 0.51
First Reported 1982
Last Reported 2011
Negated 2
Speculated 5
Reported most in Abstract
Documents 180
Total Number 186
Disease Relevance 68.48
Pain Relevance 88.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Trib3) nucleus (Trib3) enzyme binding (Trib3)
kinase activity (Trib3)
Anatomy Link Frequency
brain 5
neurons 5
midbrain 4
spinal cord dorsal horn 4
macrophages 3
Trib3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 280 100.00 Very High Very High Very High
adenocard 89 100.00 Very High Very High Very High
Kinase C inhibitor 20 100.00 Very High Very High Very High
COX2 8 100.00 Very High Very High Very High
opiate 6 99.92 Very High Very High Very High
antagonist 228 99.86 Very High Very High Very High
metalloproteinase 141 99.84 Very High Very High Very High
Analgesic 42 99.76 Very High Very High Very High
intrathecal 91 99.68 Very High Very High Very High
tetrodotoxin 12 99.66 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 220 99.64 Very High Very High Very High
Neuropathic Pain 120 99.56 Very High Very High Very High
Cardiovascular Disease 15 99.40 Very High Very High Very High
Toxicity 63 99.36 Very High Very High Very High
Hyperalgesia 187 99.34 Very High Very High Very High
Drug Dependence 24 99.30 Very High Very High Very High
Paralysis 4 99.30 Very High Very High Very High
Pancreatic Cancer 1 99.30 Very High Very High Very High
Hiatal Hernia 111 99.24 Very High Very High Very High
INFLAMMATION 462 99.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action.
Negative_regulation (inhibitor) of kinase associated with hyperalgesia, adenocard, inflammation and eae
1) Confidence 0.51 Published 2001 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 11160637 Disease Relevance 0.37 Pain Relevance 0.77
Persistent nociceptive behavior in rats induced by subcutaneous formalin injection was significantly reduced by intrathecal pretreatment with a phospholipase C inhibitor (neomycin), and an inhibitor of protein kinase C (W-7), and was significantly enhanced by a phorbol ester (phorbol 12-myristate 13-acetate, PMA) and a stimulator of protein kinase C (SC-10).
Negative_regulation (inhibitor) of kinase associated with nociception, kinase c and intrathecal
2) Confidence 0.49 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1501774 Disease Relevance 0.51 Pain Relevance 0.53
Acute administration or morphine to foetuses and neonates either directly or via the mother leads to a decrease in the total pyruvate kinase activity. 2.
Negative_regulation (decrease) of kinase associated with morphine
3) Confidence 0.45 Published 1982 Journal Int. J. Biochem. Section Abstract Doc Link 7067901 Disease Relevance 0 Pain Relevance 0.27
The decrease in the total pyruvate kinase activity and the L/M ratio is more prominent when the route of administration of morphine is via the mother. 4.
Negative_regulation (decrease) of kinase associated with morphine
4) Confidence 0.45 Published 1982 Journal Int. J. Biochem. Section Abstract Doc Link 7067901 Disease Relevance 0 Pain Relevance 0.31
Changed sensitivity of alpha 2-adrenoceptors mediating a decrease in protein kinase inhibitor activity in the brain of vasopressin-hypertensive rats.
Negative_regulation (decrease) of kinase in brain associated with hypertension
5) Confidence 0.40 Published 1986 Journal Eur. J. Pharmacol. Section Title Doc Link 3007171 Disease Relevance 0.30 Pain Relevance 0.41
Clonidine produced an increase of cGMP content and a decrease of the endogenous type II inhibitor of protein kinase in rat hypothalamic slices.
Negative_regulation (inhibitor) of kinase associated with clonidine
6) Confidence 0.40 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3007171 Disease Relevance 0.19 Pain Relevance 0.25
Extracellular levels of adenosine (ADO) can be raised through inhibition of adenosine kinase (AK), a primary metabolic enzyme for ADO.
Negative_regulation (inhibition) of kinase associated with adenocard
7) Confidence 0.40 Published 2001 Journal Brain Res. Section Abstract Doc Link 11423084 Disease Relevance 0.30 Pain Relevance 0.54
Our data suggest that the inhibition of pyruvate kinase by phenylalanine decreases glycolysis and energy production, and that alanine, a known competitor of phenylalanine on the enzyme activity, prevents the reduction of glycolysis and energy production caused by phenylalanine, probably by preventing the enzyme inhibition provoked by the amino acid.
Negative_regulation (inhibition) of kinase
8) Confidence 0.40 Published 2003 Journal Metab Brain Dis Section Abstract Doc Link 12603085 Disease Relevance 0.08 Pain Relevance 0.06
Lead inhibits in vitro creatine kinase and pyruvate kinase activity in brain cortex of rats.
Negative_regulation (inhibits) of kinase in brain
9) Confidence 0.36 Published 2010 Journal Toxicol In Vitro Section Title Doc Link 19925858 Disease Relevance 0.27 Pain Relevance 0
Lead inhibits in vitro creatine kinase and pyruvate kinase activity in brain cortex of rats.
Negative_regulation (inhibits) of kinase in brain
10) Confidence 0.36 Published 2010 Journal Toxicol In Vitro Section Title Doc Link 19925858 Disease Relevance 0.27 Pain Relevance 0
Thus, hyperalgesia induced by prostaglandin E2, prostacyclin (prostaglandin I2), (8R,15S)-dihydroxyicosa(5E-9,11,13Z)tetraenoic acid, the adenosine A2-agonist 2-phenylaminoadenosine, 8-bromocyclic adenosine monophosphate and the direct activator of adenyl cyclase, forskolin, were not significantly attenuated by the selective inhibition of protein kinase C by the 19-31 fragment of protein kinase C.
Negative_regulation (inhibition) of kinase associated with kinase c, adenocard, hyperalgesia and agonist
11) Confidence 0.30 Published 1991 Journal Neuroscience Section Abstract Doc Link 1722888 Disease Relevance 0.55 Pain Relevance 1.23
Two other inhibitors of protein kinase C, sphingosine and staurosporine, also failed to attenuate prostaglandin E2-induced hyperalgesia.
Negative_regulation (inhibitors) of kinase associated with hyperalgesia and kinase c
12) Confidence 0.30 Published 1991 Journal Neuroscience Section Abstract Doc Link 1722888 Disease Relevance 0.52 Pain Relevance 1.09
Tyrphostin A-23 (a highly selective tyrosine kinase inhibitor) 1 and 10 nM significantly decreased the sevoflurane-stimulated glucose uptake from 32.1 +/- 1.8 to 25.8 +/- 1.1 and 15.2 +/- 1.7 pmol. h(-1). mg protein(-1), respectively.
Negative_regulation (inhibitor) of kinase
13) Confidence 0.30 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12088955 Disease Relevance 0 Pain Relevance 0.07
Genistein (a selective tyrosine kinase inhibitor) 1 and 10 nM also significantly decreased the sevoflurane- stimulated glucose uptake from 32.1 +/- 1.8 to 25.7 +/- 1.5 and 15.2 +/- 1.4 pmol. h(-1). mg protein(-1), respectively.
Negative_regulation (inhibitor) of kinase
14) Confidence 0.30 Published 2002 Journal Anesth. Analg. Section Abstract Doc Link 12088955 Disease Relevance 0 Pain Relevance 0.14
The effects of G-protein and protein kinase inhibitors on the behavioral responses of rats to intradermal injection of capsaicin.
Negative_regulation (inhibitors) of kinase associated with qutenza
15) Confidence 0.30 Published 1997 Journal Pain Section Title Doc Link 9211478 Disease Relevance 0.27 Pain Relevance 1.19
A microdialysis fiber was implanted in the spinal cord dorsal horn for administration of G-protein and protein kinase inhibitors to decipher the role of signal transduction cascades in mechanical allodynia induced by intradermal injection of capsaicin.
Negative_regulation (inhibitors) of kinase in spinal cord dorsal horn associated with qutenza, allodynia, dorsal horn and spinal cord
16) Confidence 0.30 Published 1997 Journal Pain Section Abstract Doc Link 9211478 Disease Relevance 0.23 Pain Relevance 0.74
A-134974: a novel adenosine kinase inhibitor, relieves tactile allodynia via spinal sites of action in peripheral nerve injured rats.
Negative_regulation (inhibitor) of kinase in peripheral nerve associated with brush evoked pain, adenocard and nociceptor
17) Confidence 0.30 Published 2001 Journal Brain Res. Section Title Doc Link 11423084 Disease Relevance 0.40 Pain Relevance 1.27
Infusion of a G-protein inhibitor (GDP-beta-S), a general protein kinase inhibitor (H7), or selective inhibitors of protein kinase C (NPC15437), protein kinase A (H89), or protein kinase G (KT5823) into the spinal cord dorsal horn reversed the mechanical allodynia induced by intradermal injection of capsaicin in a dose-dependent manner by increasing the threshold to mechanical stimulation towards baseline.
Negative_regulation (inhibitors) of kinase in spinal cord dorsal horn associated with kinase c, qutenza, allodynia, dorsal horn and spinal cord
18) Confidence 0.29 Published 1997 Journal Pain Section Abstract Doc Link 9211478 Disease Relevance 0.37 Pain Relevance 1.27
Infusion of a G-protein inhibitor (GDP-beta-S), a general protein kinase inhibitor (H7), or selective inhibitors of protein kinase C (NPC15437), protein kinase A (H89), or protein kinase G (KT5823) into the spinal cord dorsal horn reversed the mechanical allodynia induced by intradermal injection of capsaicin in a dose-dependent manner by increasing the threshold to mechanical stimulation towards baseline.
Negative_regulation (inhibitors) of kinase in spinal cord dorsal horn associated with kinase c, qutenza, allodynia, dorsal horn and spinal cord
19) Confidence 0.29 Published 1997 Journal Pain Section Abstract Doc Link 9211478 Disease Relevance 0.37 Pain Relevance 1.29
Infusion of a G-protein inhibitor (GDP-beta-S), a general protein kinase inhibitor (H7), or selective inhibitors of protein kinase C (NPC15437), protein kinase A (H89), or protein kinase G (KT5823) into the spinal cord dorsal horn reversed the mechanical allodynia induced by intradermal injection of capsaicin in a dose-dependent manner by increasing the threshold to mechanical stimulation towards baseline.
Negative_regulation (inhibitors) of kinase in spinal cord dorsal horn associated with kinase c, qutenza, allodynia, dorsal horn and spinal cord
20) Confidence 0.29 Published 1997 Journal Pain Section Abstract Doc Link 9211478 Disease Relevance 0.37 Pain Relevance 1.28

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