INT71807

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 18
Total Number 19
Disease Relevance 8.90
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cp) extracellular space (Cp) oxidoreductase activity (Cp)
extracellular region (Cp)
Anatomy Link Frequency
plasma 1
blood 1
neuron 1
lateral 1
EBL 1
Cp (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 106 99.72 Very High Very High Very High
GABAergic 51 97.96 Very High Very High Very High
dexamethasone 22 96.72 Very High Very High Very High
Ultiva 6 95.24 Very High Very High Very High
Paracetamol 5 93.80 High High
Arthritis 18 91.32 High High
epidural 2 88.80 High High
COX-2 inhibitor 2 86.08 High High
Pyramidal cell 6 85.48 High High
antagonist 8 74.12 Quite High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 152 100.00 Very High Very High Very High
Hemorrhage 28 100.00 Very High Very High Very High
Cerebral Palsy 28 100.00 Very High Very High Very High
Muscular Dystrophy 16 99.80 Very High Very High Very High
INFLAMMATION 116 99.72 Very High Very High Very High
Neurodegenerative Disease 6 99.56 Very High Very High Very High
Pressure And Volume Under Development 42 98.68 Very High Very High Very High
Targeted Disruption 12 98.48 Very High Very High Very High
Cancer 250 97.20 Very High Very High Very High
Squamous Cell Carcinoma 18 92.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found ceruloplasmin (Cp) that was strongly induced by LPS (neuroprotection) and completely inhibited by the GR blockade (a neurotoxic condition).
Negative_regulation (inhibited) of Cp
1) Confidence 0.58 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.32 Pain Relevance 0.04
A protective effect of CP was also observed with respect to depletion of non-protein sulfhydryl compounds, cysteine and glycogen.
Negative_regulation (effect) of CP
2) Confidence 0.55 Published 1997 Journal Fundam Clin Pharmacol Section Abstract Doc Link 9342599 Disease Relevance 0.16 Pain Relevance 0.41
We found ceruloplasmin (Cp) that was strongly induced by LPS (neuroprotection) and completely inhibited by the GR blockade (a neurotoxic condition).
Negative_regulation (inhibited) of ceruloplasmin
3) Confidence 0.43 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1819560 Disease Relevance 0.32 Pain Relevance 0.04
In our recent study (Yang et al., 2009), CPZ-exposed mice showed obvious myelin sheath loss in the ventral and lateral parts of CP, where smaller fiber tracts are located.
Negative_regulation (loss) of CP in lateral
4) Confidence 0.17 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0 Pain Relevance 0
Significant decreases in the amount of MBP in CP were seen in all experiments (Figure 7).
Negative_regulation (decreases) of CP
5) Confidence 0.14 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0 Pain Relevance 0.03
Both CP and indomethacin were not selective inhibitors of COX-2 (Fig. 4).
Negative_regulation (inhibitors) of CP
6) Confidence 0.11 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 1.17 Pain Relevance 0.45
METHODS: 28 ASA III patients, scheduled for cardiac surgery, were randomized in two groups: Group pTCI received remifentanil to achieve an effect-site target of 15 ng ml(-1) by limiting Cp to 15 ng ml(-1) and group eTCI received remifentanil to achieve an effect-site target of 15 ng ml(-1) without limiting remifentanil Cp.
Negative_regulation (limiting) of Cp
7) Confidence 0.10 Published 2007 Journal Acta Anaesthesiol Belg Section Body Doc Link 17486919 Disease Relevance 0 Pain Relevance 0
TM treatment was started at 0.7 mg/day per mouse and then titrated biweekly to maintain ceruloplasmin suppression at 20% to 30% of baseline.
Negative_regulation (suppression) of ceruloplasmin
8) Confidence 0.10 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 0.90 Pain Relevance 0
The level of plasma ceruloplasmin, which is a good surrogate marker for total body copper status, was monitored biweekly and TM dose was adjusted accordingly to maintain ceruloplasmin suppression at 20% to 30% of baseline.
Negative_regulation (suppression) of ceruloplasmin in body
9) Confidence 0.10 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2922193 Disease Relevance 1.71 Pain Relevance 0
BACKGROUND: During total intravenous anaesthesia, the target controlled infusion concentration of remifentanil can be achieved either in limiting maximum plasma concentration (Cp) to the effect site target concentration which corresponds to a plasma TCI technique (pTCI) or as fast as possible to achieve the effect-site target without limiting Cp (eTCI).
Negative_regulation (limiting) of Cp in plasma associated with ultiva
10) Confidence 0.09 Published 2007 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 17486919 Disease Relevance 0 Pain Relevance 0.27
Serum haptoglobin was slightly reduced in CP and CK extracts-treated groups, but not significantly.
Neg (not) Negative_regulation (reduced) of CP
11) Confidence 0.08 Published 2006 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1475933 Disease Relevance 0.72 Pain Relevance 0.22
They are also in agreement with the data by Fagiolini and Hensch (2000) who observed that, employing long-term monocular deprivation as a probe for OD plasticity, the CP is prolonged into adulthood in GAD65 knock-out mice.
Negative_regulation (deprivation) of CP associated with targeted disruption
12) Confidence 0.06 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2854574 Disease Relevance 0.10 Pain Relevance 0.08
In our recent study (Yang et al., 2009), CPZ-exposed mice showed obvious myelin sheath loss in the ventral and lateral parts of CP, where smaller fiber tracts are located.
Negative_regulation (loss) of CP in ventral
13) Confidence 0.06 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0 Pain Relevance 0
These findings suggest that IGI levels cross two thresholds during development, the first setting the point after which inhibition levels are enough to allow OD plasticity to be expressed (beginning of CP); as development proceeds, the inhibitory tone further increases and crosses a second threshold, after which inhibition drastically reduces the potential for plasticity (closure of CP) (Feldman, 2000).


Negative_regulation (closure) of CP
14) Confidence 0.06 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2854574 Disease Relevance 0.16 Pain Relevance 0.09
These results indicate that in normal adult animals, where inhibitory processes have completed their development, a brief reduction of GABAergic inhibition is sufficient to reopen a window of plasticity in the visual cortex well after the normal closure of the CP.
Negative_regulation (closure) of CP in cortex associated with gabaergic
15) Confidence 0.06 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2854574 Disease Relevance 0.05 Pain Relevance 0.15
We agree that other factors, such as an altered bleeding profile during surgery, are also important and may result in greater blood loss in CP and DMD patients; however, when we compare both groups, the poorer bone quality observed in DMD patients compared to CP patients resulted in sudden increases in per-level EBL during the correction procedures.
Negative_regulation (loss) of CP in blood associated with pressure volume 2 under development, muscular dystrophy, cerebral palsy and hemorrhage
16) Confidence 0.03 Published 2010 Journal Scoliosis Section Body Doc Link PMC2924263 Disease Relevance 1.70 Pain Relevance 0.03
This increase in EBL was primarily due to bone bleeding in CP and paralytic patients.
Negative_regulation (bleeding) of CP in EBL associated with pressure volume 2 under development, cerebral palsy and hemorrhage
17) Confidence 0.02 Published 2010 Journal Scoliosis Section Body Doc Link PMC2924263 Disease Relevance 1.59 Pain Relevance 0.07
The mean CP across the population was only significantly different from chance for the subset of sessions in which the performance was very good for the easiest trials, and decreased as sessions including poorer peak performance were included (Fig. 9E).
Negative_regulation (decreased) of CP
18) Confidence 0.01 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610398 Disease Relevance 0 Pain Relevance 0
The lack of a CP significantly different from chance for the sessions in which the behavior was biased towards the Ineff stimulus suggests that the cells play a different role in the population in sessions in which the monkey was biased in favor of the stimulus preferred by the neuron vs. those in which the monkey was biased away from that stimulus.
Negative_regulation (lack) of CP in neuron
19) Confidence 0.01 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2610398 Disease Relevance 0 Pain Relevance 0

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