INT71824

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Context Info
Confidence 0.38
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 4.90
Pain Relevance 6.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pdpk1) cytoplasmic membrane-bounded vesicle (Pdpk1) plasma membrane (Pdpk1)
nucleus (Pdpk1) kinase activity (Pdpk1) cytoplasm (Pdpk1)
Anatomy Link Frequency
spinal 2
neurons 2
spinal cord 1
cleavage 1
cortex 1
Pdpk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 11 100.00 Very High Very High Very High
Spinal cord 53 99.84 Very High Very High Very High
Inflammation 53 99.48 Very High Very High Very High
Morphine 24 99.16 Very High Very High Very High
Spinal nerve ligature 57 98.68 Very High Very High Very High
tolerance 18 98.12 Very High Very High Very High
agonist 17 98.12 Very High Very High Very High
bDMF 32 98.00 Very High Very High Very High
spinal dorsal horn 13 97.40 Very High Very High Very High
Eae 81 95.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 53 99.48 Very High Very High Very High
Primary Sclerosing Cholangitis 8 97.18 Very High Very High Very High
Inflammatory Pain 56 95.64 Very High Very High Very High
Reperfusion Injury 3 95.52 Very High Very High Very High
Neuropathic Pain 65 94.84 High High
Propionic Acidemia 2 93.52 High High
Apoptosis 19 91.12 High High
Depression 92 85.12 High High
Parkinson's Disease 5 83.28 Quite High
Nociception 37 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The antisense also attenuated protein kinase C-mediated phosphorylation in spinal cord.
Phosphorylation (phosphorylation) of protein kinase in spinal cord associated with kinase c and spinal cord
1) Confidence 0.38 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.58
These results demonstrate that selective reduction in the expression of the spinal protein kinase Calpha isozyme followed by a decrease of local protein kinase C-mediated phosphorylation will reverse spinal morphine infusion-induced tolerance.
Phosphorylation (phosphorylation) of protein kinase in spinal associated with kinase c, tolerance and morphine
2) Confidence 0.33 Published 2002 Journal Neuroscience Section Abstract Doc Link 12123688 Disease Relevance 0 Pain Relevance 1.39
, phosphoinositide 3-kinase (PI3K), phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and phosphorylation of phosphoinositide-dependent kinase-1 (PDK1) (Ser241).
Phosphorylation (phosphorylation) of phosphoinositide-dependent kinase
3) Confidence 0.20 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2712760 Disease Relevance 0.35 Pain Relevance 0.22
In hemiparkinsonian rats, KW6002 reversed the intermittent L-dopa treatment-induced, protein kinase A-mediated hyperphosphorylation of striatal alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid receptor GluR1 S845 residues and the concomitant shortening in motor response duration.
Phosphorylation (hyperphosphorylation) of protein kinase
4) Confidence 0.13 Published 2003 Journal Neurology Section Abstract Doc Link 14663022 Disease Relevance 0.58 Pain Relevance 0.32
The authors also found up-regulation of cyclooxygenase-2 expression and phosphorylation of protein kinase Akt at Ser-473 in response to opioid withdrawal.
Phosphorylation (phosphorylation) of protein kinase
5) Confidence 0.13 Published 2006 Journal Anesthesiology Section Body Doc Link 16810007 Disease Relevance 0 Pain Relevance 0
Furthermore, protein kinase C-dependent phosphorylation of Ser800 in the TRPV1 C terminus potentiated agonist-evoked ionic selectivity changes.
Phosphorylation (phosphorylation) of protein kinase associated with kinase c and agonist
6) Confidence 0.09 Published 2008 Journal Nat. Neurosci. Section Abstract Doc Link 18391945 Disease Relevance 0 Pain Relevance 0.42
Sensitization of PSC with culture duration was accompanied by increased expression of CD95 and TRAIL receptor 2 and no alterations of Flip expression or protein kinase B phosphorylation but was paralleled by the appearance of a COOH-terminal cleavage product of receptor-interacting protein.
Phosphorylation (phosphorylation) of kinase B in cleavage associated with primary sclerosing cholangitis
7) Confidence 0.09 Published 2002 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 12181199 Disease Relevance 1.72 Pain Relevance 0.07
Considering that the endogenous phosphorylating system associated with the cytoskeletal fraction contains cAMP-dependent protein kinase (PKA), Ca2+/calmodulin protein kinase II (CaMKII), and protein phosphatase 1 (PP1), we first assayed the effect of the acid on the kinase activities by using the specific activators cAMP and Ca2+/calmodulin or the inhibitors PKAI or KN-93 for PKA and CaMKII, respectively.
Phosphorylation (phosphorylating) of protein kinase
8) Confidence 0.08 Published 1997 Journal Exp. Neurol. Section Abstract Doc Link 9344549 Disease Relevance 0.09 Pain Relevance 0.04
RESULTS: After single injection, we found that FGF-2 mRNA levels were selectively upregulated in the prefrontal cortex only when the two drugs were coadministered, an effect paralleled by a significant increase of phosphorylated protein kinase B (P-Akt) levels.
Phosphorylation (phosphorylated) of kinase B in cortex
9) Confidence 0.06 Published 2004 Journal Biol. Psychiatry Section Body Doc Link 15158429 Disease Relevance 0 Pain Relevance 0
Similarly, Protein kinase C phosphorylation of GluR2 at Ser880 disrupts GluR2 binding to its synaptic anchoring protein ABP/GRIP and promotes GluR2 internalization in cultured hippocampal neurons [36,37].
Phosphorylation (phosphorylation) of Protein kinase in neurons associated with kinase c
10) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.39 Pain Relevance 0.48
Protein kinase A phosphorylation of GluR1 Ser845 promotes the surface-expression of GluR1 in cultured hippocampal neurons during activity-dependent long-term potentiation [35] and might also be responsible for spinal GluR1 membrane insertion in vivo following CFA-induced inflammation.
Phosphorylation (phosphorylation) of Protein kinase in spinal associated with inflammation and long-term potentiation
11) Confidence 0.03 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628655 Disease Relevance 0.40 Pain Relevance 0.49
IPC activates PI3-kinase which facilitates phosphorylation and activation of the protein kinase Akt through its mediator PDK-1 [1].
Phosphorylation (phosphorylation) of protein kinase
12) Confidence 0.03 Published 2010 Journal Basic Res Cardiol Section Body Doc Link PMC3012213 Disease Relevance 0.20 Pain Relevance 0.05
Our point also gets literature supports in that SNL induced an immediate (<10 min) but transient (<6 h) induction of phosphorylated extracellular regulated protein kinase (pERK, marker for activated cells) restricted to neurons in the SDH, while shutdown of these activated neurons attenuated the mechanic allodynia [34].
Phosphorylation (phosphorylated) of protein kinase in neurons associated with allodynia, spinal dorsal horn and spinal nerve ligature
13) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.87 Pain Relevance 0.99
As the name suggests, it involves the cAMP cascade and cAMP dependent protein kinase for activation and phosphorylation respectively [95, 209].
Phosphorylation (phosphorylation) of protein kinase
14) Confidence 0.01 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2687932 Disease Relevance 0.30 Pain Relevance 0.82

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