INT71847

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Context Info
Confidence 0.33
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.61
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col3a1) extracellular region (Col3a1)
Col3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
fibrosis 18 98.68 Very High Very High Very High
Morphine 13 98.36 Very High Very High Very High
nalbuphine 1 93.56 High High
Kinase C inhibitor 1 79.52 Quite High
metalloproteinase 4 75.60 Quite High
addiction 1 59.68 Quite High
antagonist 5 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Calcium channel 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 14 98.68 Very High Very High Very High
Adhesions 2 89.60 High High
Dilated Cardiomyopathy 2 79.44 Quite High
Coronary Heart Disease 18 77.32 Quite High
Renal Disease 1 71.64 Quite High
Keloid Scars 1 69.36 Quite High
Immunization 15 63.60 Quite High
Hypertension 7 56.04 Quite High
Autoimmune Disease 2 50.00 Quite Low
Myocardial Infarction 5 29.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine enhanced the accumulation of collagen type I in a dose-dependent manner and also increased (p < 0.001) the accumulation of collagen type III at a high concentration (control, 1,291+/-55.8 vs. morphine, 10(-4) M, 2,697.6+/-257.8 ng/microg protein).
Positive_regulation (increased) of Positive_regulation (accumulation) of collagen type III associated with morphine
1) Confidence 0.33 Published 1997 Journal Nephron Section Abstract Doc Link 9346391 Disease Relevance 0.14 Pain Relevance 1.25
The increased accumulation of collagen I and III has been associated mostly with fibrosis [18], [19].
Positive_regulation (increased) of Positive_regulation (accumulation) of collagen I and III associated with fibrosis
2) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.46 Pain Relevance 0.14

General Comments

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