INT71868

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Context Info
Confidence 0.52
First Reported 1997
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 9
Total Number 13
Disease Relevance 10.73
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tenc1)
Anatomy Link Frequency
brain 2
fat 1
striatum 1
lung 1
thickening 1
Tenc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropathic pain 82 100.00 Very High Very High Very High
Enkephalin 15 100.00 Very High Very High Very High
Osteoarthritis 11 99.84 Very High Very High Very High
Inflammation 29 99.56 Very High Very High Very High
Opioid 14 99.48 Very High Very High Very High
Central nervous system 4 98.68 Very High Very High Very High
fibrosis 5 97.38 Very High Very High Very High
antagonist 6 96.80 Very High Very High Very High
qutenza 2 94.72 High High
Spinal cord 4 94.64 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 114 100.00 Very High Very High Very High
Normal Pressure Hydrocephalus 48 100.00 Very High Very High Very High
Aging 6 100.00 Very High Very High Very High
Dermatitis 8 99.98 Very High Very High Very High
Osteoarthritis 11 99.84 Very High Very High Very High
Disease 191 99.68 Very High Very High Very High
INFLAMMATION 29 99.56 Very High Very High Very High
Alzheimer's Dementia 98 99.48 Very High Very High Very High
Injury 46 98.68 Very High Very High Very High
Burns 44 98.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neither a low nor a high dose of the NEP inhibitor had an effect on NEP activity in the brain cortex (Figure 4d, right panel).
Regulation (effect) of NEP in brain
1) Confidence 0.52 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.33 Pain Relevance 0
Neither the amount of muscle mass nor of body fluid was altered in NEP knockouts (Figures 2a and b), whilst there was significant fat accumulation (Figure 2c and d).
Neg (Neither) Regulation (altered) of NEP in fat
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.75 Pain Relevance 0.03
Furthermore, in the brain regions studied, the corresponding enzyme activities of NEP and ACE did not differ significantly between the lines of mice, except for a higher NEP activity in the striatum and olfactory bulb of DBA/2 mice (p < 0.01).
Neg (except) Regulation (differ) of NEP in olfactory bulb
3) Confidence 0.33 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756041 Disease Relevance 0.32 Pain Relevance 0.35
Mechanisms of toxic smoke inhalation and burn injury: Role of neutral endopeptidase and vascular leakage in mice

The effects of neutral endopeptidase (NEP) in acute inflammation in the lung were studied using a newly developed murine model of smoke and burn (SB) injury.

Regulation (effects) of NEP in lung associated with inflammation, burns and injury
4) Confidence 0.23 Published 2009 Journal Toxicology Mechanisms and Methods Section Title Doc Link PMC2736052 Disease Relevance 1.66 Pain Relevance 0.14
All data shown here demonstrate a significant effect of lower NEP activity (either by pharmacological inhibition or genetic manipulation) on fat accumulation and thus pathological gain in body weight.
Regulation (effect) of NEP in body associated with body weight
5) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2940827 Disease Relevance 0.95 Pain Relevance 0
The augmented ACD response in NEP(-/-) animals was abrogated by either administration of a neurokinin receptor 1 antagonist or by repeated pretreatment with topical capsaicin.
Regulation (response) of NEP associated with qutenza, antagonist and dermatitis
6) Confidence 0.22 Published 2001 Journal J. Immunol. Section Abstract Doc Link 11145711 Disease Relevance 1.32 Pain Relevance 0.47
Age-related accumulations of amyloid in the choroid plexus and meninges, fibrosis, thickening of the basement membrane, and senescent changes in the choroidal epithelium and choroidal vasculature probably play a role both in decreased CSF production and decreased CSF absorption in normal aging, in NPH and in AD [1,12,15,16].
Regulation (role) of NPH in thickening associated with fibrosis, normal pressure hydrocephalus, aging, alzheimer's dementia and disease
7) Confidence 0.20 Published 2006 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC1538629 Disease Relevance 1.63 Pain Relevance 0.09
The observation that the non-neuropathic condition OA has been diagnosed in an appreciable proportion of (putative) NeP patients is consistent with previously published data that NeP patients are disproportionably affected by OA [20].
Regulation (affected) of NeP associated with neuropathic pain and osteoarthritis
8) Confidence 0.18 Published 2007 Journal BMC Public Health Section Body Doc Link PMC1947963 Disease Relevance 1.56 Pain Relevance 1.14
Regional differences in opioid metabolism indicate that NEP evokes tissue-specific patterns of ENK-regulation.
Regulation (regulation) of NEP associated with enkephalin and opioid
9) Confidence 0.12 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9347938 Disease Relevance 0.36 Pain Relevance 1.44
Furthermore, in the brain regions studied, the corresponding enzyme activities of NEP and ACE did not differ significantly between the lines of mice, except for a higher NEP activity in the striatum and olfactory bulb of DBA/2 mice (p < 0.01).
Neg (except) Regulation (differ) of NEP in striatum
10) Confidence 0.11 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9756041 Disease Relevance 0.32 Pain Relevance 0.35
In this study, we examined the activity of IDE and NEP on formation of relevant ?
Spec (examined) Regulation (activity) of NEP
11) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.27 Pain Relevance 0.05
We have examined the ability of IDE and NEP to generate amyloid-forming species from the exposed and non-amyloidogenic hAChE T40 oligomerisation domain and the consequences for heterologous seeding of A?
Spec (examined) Regulation (ability) of NEP associated with alzheimer's dementia
12) Confidence 0.10 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.55 Pain Relevance 0
Furthermore, in mice having both copies of NEP genes silenced, the loss of function lead to an elevation in the brain and in plasma of A?
Regulation (copies) of NEP in brain
13) Confidence 0.05 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2726140 Disease Relevance 0.71 Pain Relevance 0.03

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