INT71870

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 4.27
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
marginal zone 2
B cell 2
lung 2
appendix 2
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 4 99.72 Very High Very High Very High
endometriosis 5 99.36 Very High Very High Very High
Spinal cord 3 99.24 Very High Very High Very High
Inflammation 10 94.96 High High
Enkephalin 9 94.76 High High
trigeminal ganglion 1 92.96 High High
Pain 2 91.84 High High
Analgesic 1 83.92 Quite High
Morphine 1 82.88 Quite High
abdominal pain 3 75.92 Quite High
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 84 99.98 Very High Very High Very High
Endometriosis (extended) 5 99.36 Very High Very High Very High
Adult Respiratory Distress Syndrome 88 98.96 Very High Very High Very High
B-cell Chronic Lymphocytic Leukemia 12 98.92 Very High Very High Very High
Disease 77 95.48 Very High Very High Very High
INFLAMMATION 14 94.96 High High
Hyperplasia 2 94.00 High High
Ganglion Cysts 1 92.96 High High
Targeted Disruption 13 92.56 High High
Appendicitis 1 88.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that deletion of the NEP gene results in an opioid-related increase in thermonociceptive threshold.
Positive_regulation (results) of Gene_expression (deletion) of NEP gene associated with opioid
1) Confidence 0.48 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9347938 Disease Relevance 0.38 Pain Relevance 1.47
Furthermore, the expression and activity of neprilysin, an A?
Positive_regulation (activity) of Gene_expression (expression) of neprilysin
2) Confidence 0.45 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.79 Pain Relevance 0.06
Elevated NEP activity in the BALF of mice with acute lung injury
Positive_regulation (Elevated) of Gene_expression (activity) of NEP in lung associated with adult respiratory distress syndrome
3) Confidence 0.44 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.26 Pain Relevance 0
These stroma cells were positive for CD10 on immunohistochemical staining, establishing a diagnosis of endometriosis of the appendix.
Positive_regulation (establishing) of Gene_expression (positive) of CD10 in appendix associated with endometriosis
4) Confidence 0.17 Published 2010 Journal Hiroshima J. Med. Sci. Section Abstract Doc Link 20632687 Disease Relevance 0.63 Pain Relevance 0.40
The immunophenotype of marginal lymphomas is distinct from other small lymphocytic lymphomas: the antigen profile for the marginal zone lymphomas include CD19, CD20, CD22 positive and CD5, CD10, CD23, and CD11C negative.
Positive_regulation (include) of Neg (negative) Gene_expression (negative) of CD10 in marginal zone associated with b-cell chronic lymphocytic leukemia and lymphatic system cancer
5) Confidence 0.11 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721318 Disease Relevance 1.16 Pain Relevance 0
Flowcytometric analysis revealed a B cell population expressing CD19, CD20, CD22, CD10(dim), surface IgG, HLA-DR and CD43, but negative for CD5, CD34, and tdT.
Positive_regulation (population) of Neg (negative) Gene_expression (expressing) of CD10 in B cell
6) Confidence 0.04 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1904237 Disease Relevance 1.05 Pain Relevance 0.07

General Comments

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