INT71875

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 92
Total Number 95
Disease Relevance 48.13
Pain Relevance 22.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
nucleus 13
macrophages 3
inner nuclear layer 3
urinary bladder 3
ganglion cell layer 3
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 296 100.00 Very High Very High Very High
chemokine 127 100.00 Very High Very High Very High
Pain 34 100.00 Very High Very High Very High
Analgesic 23 100.00 Very High Very High Very High
electroacupuncture 8 100.00 Very High Very High Very High
substance P 199 99.82 Very High Very High Very High
excitatory amino acid 1 99.80 Very High Very High Very High
Sciatic nerve 15 99.68 Very High Very High Very High
Hyperalgesia 10 99.46 Very High Very High Very High
lidocaine 2 99.38 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 515 100.00 Very High Very High Very High
Targeted Disruption 78 99.96 Very High Very High Very High
Diabetes Mellitus 88 99.82 Very High Very High Very High
Injury 90 99.68 Very High Very High Very High
Hyperalgesia 12 99.46 Very High Very High Very High
Cancer 190 99.24 Very High Very High Very High
Necrosis 52 98.96 Very High Very High Very High
Hemophilus Infection 178 98.90 Very High Very High Very High
INFLAMMATION 907 98.80 Very High Very High Very High
Death 251 98.74 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.
Localization (translocation) of NF-kappaB in skin associated with qutenza
1) Confidence 0.78 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.18 Pain Relevance 0.58
The effect of ME10092 treatment (1-100 pmol/mouse) on nuclear translocation of NF-kappaB, activation of expression of inflammatory mediators and production of nitric oxide were measured in the lipopolysaccharide (LPS)-induced brain inflammation model in mice in vivo.
Localization (translocation) of NF-kappaB in brain associated with inflammatory mediators, inflammation and encephalitis
2) Confidence 0.78 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.41 Pain Relevance 0.21
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Localization (translocation) of NF-kappaB associated with necrosis and cancer
3) Confidence 0.78 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.52 Pain Relevance 0.24
In further studies, NNU-hdpa was found to significantly inhibit the productions of PGE(2) and LTB(4) in LPS-challenged RAW 264.7, which is parallel to its prevention of the nuclear translocation of the NF-kappaB p50 and p65 subunits.
Localization (translocation) of p50 in RAW 264
4) Confidence 0.78 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19345206 Disease Relevance 0.45 Pain Relevance 0.29
Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.
Localization (translocation) of NF-kappaB in neutrophils associated with anesthesia, inflammation, injury and isoflurane
5) Confidence 0.78 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.31 Pain Relevance 1.06
Treatment with taurine and niacin generally inhibited the BL-induced increases in the nuclear localization of NF-kappaB and preserved IkappaBalpha protein in BL + TN groups.
Localization (localization) of NF-kappaB
6) Confidence 0.77 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.15 Pain Relevance 0.15
Decrease of the electroacupuncture-induced analgesic effects in nuclear factor-kappa B1 knockout mice.
Localization (Decrease) of nuclear factor-kappa B1 associated with targeted disruption, pain, analgesic and electroacupuncture
7) Confidence 0.75 Published 2002 Journal Neurosci. Lett. Section Title Doc Link 11834313 Disease Relevance 0.19 Pain Relevance 0.76
We previously reported that depletion of glutathione in murine hepatocytes by diethylmaleate (DEM) or acetaminophen (APAP) leads to oxidative stress-dependent necrosis and sensitizes to tumor necrosis factor (TNF)-induced apoptosis in an oxidative stress-independent fashion, which could not be explained by interference with nuclear factor kappaB (NF-kappaB) nuclear translocation.
Localization (translocation) of nuclear factor kappaB in hepatocytes associated with stress, necrosis, paracetamol, cancer and apoptosis
8) Confidence 0.73 Published 2003 Journal Hepatology Section Abstract Doc Link 12774022 Disease Relevance 0.90 Pain Relevance 0.34
We previously reported that depletion of glutathione in murine hepatocytes by diethylmaleate (DEM) or acetaminophen (APAP) leads to oxidative stress-dependent necrosis and sensitizes to tumor necrosis factor (TNF)-induced apoptosis in an oxidative stress-independent fashion, which could not be explained by interference with nuclear factor kappaB (NF-kappaB) nuclear translocation.
Localization (translocation) of NF-kappaB in hepatocytes associated with stress, necrosis, paracetamol, cancer and apoptosis
9) Confidence 0.73 Published 2003 Journal Hepatology Section Abstract Doc Link 12774022 Disease Relevance 0.89 Pain Relevance 0.34
We demonstrate that Keap1/Nrf2 and NF-kappaB respond differently to electrophiles that bind proteins covalently and the redox perturbation associated with glutathione depletion, and that crosstalk may enable NF-kappaB to partly influence Nrf2 expression during cellular stress.
Localization (respond) of NF-kappaB associated with stress
10) Confidence 0.72 Published 2010 Journal Biochem. Pharmacol. Section Abstract Doc Link 20416283 Disease Relevance 0.48 Pain Relevance 0.10
Differential effect of covalent protein modification and glutathione depletion on the transcriptional response of Nrf2 and NF-kappaB.
Localization (response) of NF-kappaB
11) Confidence 0.72 Published 2010 Journal Biochem. Pharmacol. Section Title Doc Link 20416283 Disease Relevance 0.40 Pain Relevance 0.11
PEA prevented IkB-alpha degradation and p65 NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral hyperalgesia.
Localization (translocation) of NF-kappaB associated with hyperalgesia
12) Confidence 0.71 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.61 Pain Relevance 0.81
PEA prevented IkB-alpha degradation and NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral inflammation.
Localization (translocation) of NF-kappaB associated with inflammation
13) Confidence 0.70 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.50 Pain Relevance 0.50
Moreover, the translocation of NF-kappaB in nucleus resulted from Ang II was reduced by treatment with U0126.
Localization (translocation) of NF-kappaB in nucleus
14) Confidence 0.68 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.67 Pain Relevance 0.09
TRPC6 up-regulation in Ang II-induced podocyte apoptosis might result from ERK activation and NF-kappaB translocation.
Localization (translocation) of NF-kappaB in podocyte associated with apoptosis
15) Confidence 0.68 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Title Doc Link 19546355 Disease Relevance 0.67 Pain Relevance 0.14
The activation of ERK pathway and subsequent translocation of NF-kappaB was possibly necessary for the up-regulation TRPC6 induced by Ang II.
Localization (translocation) of NF-kappaB
16) Confidence 0.68 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.51 Pain Relevance 0.03
Clonidine also significantly enhanced LPS-induced NF-kappaB activation by enhancing the nuclear translocation of NF-kappaB as well as increasing the NF-kappaB-DNA binding activity.
Localization (translocation) of NF-kappaB
17) Confidence 0.68 Published 2008 Journal J. Surg. Res. Section Body Doc Link 18262561 Disease Relevance 0 Pain Relevance 0
This occurred at the transcriptional level, since the gingerol compounds decreased LPS-induced IkappaB-alpha degradation, prevented nuclear translocation of NF-kappaB p65 and reduced NF-kappaB activity in a concentration-dependent manner.
Localization (translocation) of NF-kappaB
18) Confidence 0.68 Published 2006 Journal Planta Med. Section Abstract Doc Link 16732525 Disease Relevance 0.28 Pain Relevance 0.19
Treatment with taurine and niacin generally inhibited the BL-induced increases in the nuclear localization of NF-kappaB and preserved IkappaBalpha protein in BL + TN groups.
Localization (localization) of NF-kappaB
19) Confidence 0.68 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10734156 Disease Relevance 0.15 Pain Relevance 0.15
Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia.
Localization (signalling) of NF-kappaB in dorsal root ganglia associated with hyperalgesia and analgesic
20) Confidence 0.67 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19386271 Disease Relevance 0.55 Pain Relevance 1.06

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