INT71878

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 24
Total Number 24
Disease Relevance 10.85
Pain Relevance 9.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
spinal cord 2
brain 2
nucleus 2
DRG 2
macrophage 1
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 124 99.76 Very High Very High Very High
Paracetamol 11 99.76 Very High Very High Very High
cytokine 59 99.50 Very High Very High Very High
Hyperalgesia 15 99.06 Very High Very High Very High
rheumatoid arthritis 5 98.92 Very High Very High Very High
Snapping jaw 2 98.92 Very High Very High Very High
Spinal cord 8 98.68 Very High Very High Very High
Osteoarthritis 4 97.72 Very High Very High Very High
Migraine 6 94.16 High High
withdrawal 18 93.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 141 99.76 Very High Very High Very High
Natriuresis 4 99.62 Very High Very High Very High
Hyperalgesia 18 99.06 Very High Very High Very High
Rheumatoid Arthritis 5 98.92 Very High Very High Very High
Temporomandibular Joint Disorders 1 98.92 Very High Very High Very High
Pressure And Volume Under Development 15 98.88 Very High Very High Very High
Necrosis 12 97.92 Very High Very High Very High
Cancer 22 97.74 Very High Very High Very High
Osteoarthritis 4 97.72 Very High Very High Very High
Rheumatic Diseases 1 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inflammation, cartilage degradation, cell proliferation, angiogenesis and pannus formation are processes in which the role of NF-kappaB is prominent.
Protein_catabolism (degradation) of NF-kappaB in cartilage associated with inflammation
1) Confidence 0.65 Published 2006 Journal Osteoarthr. Cartil. Section Abstract Doc Link 16730463 Disease Relevance 1.07 Pain Relevance 0.53
Treatment of Hepa 1-6 cells with H(2)O(2) was sufficient for NF-kappaB activation and IkappaBalpha degradation, and APAP was able to block both of these events.
Protein_catabolism (degradation) of NF-kappaB in Hepa 1-6 associated with paracetamol
2) Confidence 0.65 Published 2000 Journal Toxicol. Sci. Section Abstract Doc Link 10828269 Disease Relevance 0.16 Pain Relevance 0.90
To investigate the mechanism by which PEA attenuated hyperalgesia, we evaluated inhibitory kB-alpha (IkB-alpha) degradation and p65 nuclear factor kB (NF-kappaB) activation in DRG.
Protein_catabolism (degradation) of NF-kappaB in DRG associated with hyperalgesia
3) Confidence 0.58 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.68 Pain Relevance 0.90
PEA prevented IkB-alpha degradation and p65 NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral hyperalgesia.
Protein_catabolism (degradation) of NF-kappaB associated with hyperalgesia
4) Confidence 0.58 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.61 Pain Relevance 0.81
To investigate the mechanism by which PEA attenuated hyperalgesia, we evaluated inhibitory kB-alpha (IkB-alpha) degradation and p65 nuclear factor kB (NF-kappaB) activation in DRG.
Protein_catabolism (degradation) of p65 nuclear factor kB in DRG associated with hyperalgesia
5) Confidence 0.58 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.68 Pain Relevance 0.90
PEA prevented IkB-alpha degradation and NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral inflammation.
Protein_catabolism (degradation) of NF-kappaB associated with inflammation
6) Confidence 0.57 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.50 Pain Relevance 0.50
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Protein_catabolism (degradation) of NF-kappaB in spinal cord associated with pressure and volume under development and spinal cord
7) Confidence 0.57 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.52 Pain Relevance 0.50
PEA attenuated the development of carrageenan-induced paw edema, we evaluated inhibitor kappaB-alpha (I kappa B-alpha) degradation and nuclear factor-kappaB (NF-kappaB) p65 activation in the cytosolic or nuclear extracts from spinal cord tissue.
Protein_catabolism (degradation) of factor-kappaB in spinal cord associated with pressure and volume under development and spinal cord
8) Confidence 0.50 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.52 Pain Relevance 0.49
B (p50, p65/RelA, and p52/RelB) by ubiquitin-mediated degradation of inhibitor-?
Protein_catabolism (degradation) of p50
9) Confidence 0.42 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.55 Pain Relevance 0
Furthermore, MEIO inhibited the LPS-induced DNA binding activity of nuclear factor-kappaB (NF-kappaB), and this was associated with the prevention of inhibitor kappaB degradation and a reduction in nuclear p65 protein levels.
Protein_catabolism (degradation) of NF-kappaB
10) Confidence 0.40 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15905055 Disease Relevance 0.95 Pain Relevance 0.22
We also found that the degradation of IkappaB and IKK activation were inhibited by capsaicin.
Protein_catabolism (degradation) of IkappaB
11) Confidence 0.36 Published 2007 Journal Helicobacter Section Body Doc Link 17760719 Disease Relevance 0 Pain Relevance 0
However, more recently it was shown that Nkx-2.5 is required for the expression of atrial natriuretic peptide [61] and, along with NF-kappaB, is part of the brain natriuretic peptide promoter [62].
Protein_catabolism (along) of NF-kappaB in brain associated with natriuresis
12) Confidence 0.31 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.37 Pain Relevance 0.05
However, more recently it was shown that Nkx-2.5 is required for the expression of atrial natriuretic peptide [61] and, along with NF-kappaB, is part of the brain natriuretic peptide promoter [62].
Protein_catabolism (with) of NF-kappaB in brain associated with natriuresis
13) Confidence 0.31 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.37 Pain Relevance 0.05
Similarly, the study by Singer et al. showed that p38 MAPK and NF-kappa B may affect COX-2 expression in human airway myocytes via separate signaling pathways given the fact that SB203580 did not affect cytokine-stimulated IkappaBalpha degradation and NF-kappa B nuclear binding activity [23].
Protein_catabolism (degradation) of NF-kappa B in myocytes associated with cytokine
14) Confidence 0.29 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.23 Pain Relevance 0.05
Arvanil also prevents tumor necrosis factor-alpha-induced nuclear factor-kappaB (NF-kappaB) activation by direct inhibition of IkappaBalpha degradation, NF-kappaB binding to DNA, and NF-kappaB-dependent transcription.
Protein_catabolism (degradation) of NF-kappaB associated with necrosis and cancer
15) Confidence 0.18 Published 2006 Journal Mol. Pharmacol. Section Abstract Doc Link 16394182 Disease Relevance 0.41 Pain Relevance 0.31
These results suggest that EAAD has the inhibitory effects on LPS-induced TNF-alpha, NO and PGE(2) production, and expression of iNOS and COX-2 in macrophage through blockade in the phosphorylation of MAPKs, following I-kappaBalpha degradation and NF-kappaB activation.
Protein_catabolism (degradation) of NF-kappaB in macrophage
16) Confidence 0.17 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17229575 Disease Relevance 0.67 Pain Relevance 0.06
Furthermore, EAAD suppressed LPS-induced phosphorylation of p38 MAPK and extracellular-signal regulated kinases 1/2 (ERK1/2), I-kappaBalpha degradation, and NF-kappaB activation in RAW 264.7 cells.
Protein_catabolism (degradation) of NF-kappaB in RAW 264
17) Confidence 0.17 Published 2007 Journal Pharmacol. Res. Section Abstract Doc Link 17229575 Disease Relevance 1.01 Pain Relevance 0.25
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Protein_catabolism (degradation) of IkappaB in nucleus
18) Confidence 0.10 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.81
Investigating the molecular mechanisms by which parthenolide prevents iNOS/NO synthesis, we found that parthenolide inhibits the activation of p42/44 mitogen-activated protein kinase (MAPK), but not IkBalpha (IkappaBalpha) degradation or nuclear factor-kappaB (NF-kappaB) p65 activation.
Protein_catabolism (degradation) of nuclear factor-kappaB
19) Confidence 0.07 Published 2002 Journal J. Neuroimmunol. Section Abstract Doc Link 12417429 Disease Relevance 0.32 Pain Relevance 0.28
Expression of receptor activator of nuclear factor-kappaB ligand in synovial tissue: comparison with degradation of articular cartilage in temporomandibular joint disorders.
Protein_catabolism (degradation) of nuclear factor-kappaB in temporomandibular joint associated with snapping jaw
20) Confidence 0.06 Published 2007 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Title Doc Link 17560137 Disease Relevance 0.10 Pain Relevance 0.18

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