INT71879

Context Info Confidence 0.57 First Reported 1997 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 30 Total Number 30 Disease Relevance 21.80 Pain Relevance 13.48

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1) nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)

Anatomy Link Frequency nucleus 10 neutrophils 8 ganglion cell layer 6 hepatocytes 4 macrophages 2 Nfkb1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 156 100.00 excitatory amino acid 1 100.00 chemokine 27 99.98 Hyperalgesia 10 99.74 anesthesia 30 99.70 isoflurane 28 99.48 Spinal cord 2 99.48 lidocaine 2 99.38 cINOD 68 99.18 palliative 1 98.74

Disease Link Frequency Relevance Heat INFLAMMATION 151 100.00 Diabetes Mellitus 28 100.00 Hyperalgesia 12 99.74 Cancer 12 99.24 Injury 21 99.16 Necrosis 22 98.96 Stress 5 98.92 Apoptosis 22 98.60 Ganglion Cysts 8 98.52 Death 9 97.64

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In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.

Negative_regulation (inhibition) of Localization (translocation) of NF-kappaB in skin associated with qutenza

1) Confidence 0.57 Published 2001 Journal Cancer Lett. Section Abstract Doc Link 11179825 Disease Relevance 0.18 Pain Relevance 0.59

In further studies, NNU-hdpa was found to significantly inhibit the productions of PGE(2) and LTB(4) in LPS-challenged RAW 264.7, which is parallel to its prevention of the nuclear translocation of the NF-kappaB p50 and p65 subunits.

Negative_regulation (prevention) of Localization (translocation) of p50 in RAW 264

2) Confidence 0.57 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19345206 Disease Relevance 0.46 Pain Relevance 0.29

We previously reported that depletion of glutathione in murine hepatocytes by diethylmaleate (DEM) or acetaminophen (APAP) leads to oxidative stress-dependent necrosis and sensitizes to tumor necrosis factor (TNF)-induced apoptosis in an oxidative stress-independent fashion, which could not be explained by interference with nuclear factor kappaB (NF-kappaB) nuclear translocation.

Negative_regulation (interference) of Localization (translocation) of nuclear factor kappaB in hepatocytes associated with stress, necrosis, paracetamol, cancer and apoptosis

3) Confidence 0.53 Published 2003 Journal Hepatology Section Abstract Doc Link 12774022 Disease Relevance 0.90 Pain Relevance 0.34

PEA prevented IkB-alpha degradation and p65 NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral hyperalgesia.

Negative_regulation (prevented) of Localization (translocation) of NF-kappaB associated with hyperalgesia

4) Confidence 0.52 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19386271 Disease Relevance 0.62 Pain Relevance 0.87

Since bee venom and melittin delay and reduce nuclear translocation of the p50 subunit of NF?

Negative_regulation (reduce) of Localization (translocation) of p50 subunit

5) Confidence 0.48 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526601 Disease Relevance 0.91 Pain Relevance 0.50

ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).

Negative_regulation (inhibited) of Localization (translocation) of NF-kappaB associated with necrosis and cancer

6) Confidence 0.41 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.52 Pain Relevance 0.24

Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.

Negative_regulation (reduced) of Localization (translocation) of NF-kappaB in neutrophils associated with anesthesia, inflammation, injury and isoflurane

7) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.31 Pain Relevance 1.07

Mice subjected to renal IR under isoflurane anesthesia also showed a reduction in inflammation evidenced by a reduced renal influx of neutrophils and macrophages, reduced ICAM-1 expression, less upregulation of proinflammatory mRNAs (TNF-alpha, ICAM-1, KC, and IL-1beta) as well as reduced nuclear translocation of NF-kappaB 24 h after renal IR injury.

Negative_regulation (reduction) of Localization (translocation) of NF-kappaB in neutrophils associated with anesthesia, inflammation, injury and isoflurane

8) Confidence 0.41 Published 2007 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 17596528 Disease Relevance 1.40 Pain Relevance 1.12

We previously reported that depletion of glutathione in murine hepatocytes by diethylmaleate (DEM) or acetaminophen (APAP) leads to oxidative stress-dependent necrosis and sensitizes to tumor necrosis factor (TNF)-induced apoptosis in an oxidative stress-independent fashion, which could not be explained by interference with nuclear factor kappaB (NF-kappaB) nuclear translocation.

Negative_regulation (interference) of Localization (translocation) of NF-kappaB in hepatocytes associated with stress, necrosis, paracetamol, cancer and apoptosis

9) Confidence 0.39 Published 2003 Journal Hepatology Section Abstract Doc Link 12774022 Disease Relevance 0.90 Pain Relevance 0.34

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia.

Negative_regulation (inhibition) of Localization (signalling) of NF-kappaB in dorsal root ganglia associated with hyperalgesia and analgesic

10) Confidence 0.38 Published 2009 Journal Eur. J. Pharmacol. Section Title Doc Link 19386271 Disease Relevance 0.55 Pain Relevance 1.06

Furthermore, MEXS inhibited nuclear factor kappa B (NF-kappaB) DNA binding activity and the translocation of NF-kappaB to the nucleus by blocking the degradation of inhibitor of kappa B-alpha (IkappaB-alpha).

Negative_regulation (inhibited) of Localization (translocation) of NF-kappaB in nucleus

11) Confidence 0.38 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15635170 Disease Relevance 0.66 Pain Relevance 0.20

PEA prevented IkB-alpha degradation and NF-kappaB nuclear translocation, confirming the involvement of this transcriptional factor in the control of peripheral inflammation.

Negative_regulation (prevented) of Localization (translocation) of NF-kappaB associated with inflammation

12) Confidence 0.38 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17565008 Disease Relevance 0.51 Pain Relevance 0.51

Therefore, we hypothesized that excessive IL-6 expression decreased LPS-induced neutrophil emigration in p50-deficient mice.

Negative_regulation (decreased) of Localization (emigration) of p50 in neutrophil

13) Confidence 0.37 Published 2004 Journal BMC Immunol Section Body Doc Link PMC449706 Disease Relevance 0.23 Pain Relevance 0.23

Moreover, the translocation of NF-kappaB in nucleus resulted from Ang II was reduced by treatment with U0126.

Negative_regulation (reduced) of Localization (translocation) of NF-kappaB in nucleus

14) Confidence 0.36 Published 2009 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 19546355 Disease Relevance 0.68 Pain Relevance 0.09

In support of this concept, we found, using inhibitors of Jun kinase and NF-kappaB p50 nuclear localization, that COX-2 gene transcription was completely dependent on phospho-c-Jun plus p50 at 6 h after LPS treatment but was only partially dependent on the combination of these factors at later treatment times.

Negative_regulation (inhibitors) of Localization (localization) of p50

15) Confidence 0.33 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114486 Disease Relevance 0.31 Pain Relevance 0.11

In support of this concept, we found, using inhibitors of Jun kinase and NF-kappaB p50 nuclear localization, that COX-2 gene transcription was completely dependent on phospho-c-Jun plus p50 at 6 h after LPS treatment but was only partially dependent on the combination of these factors at later treatment times.

Negative_regulation (inhibitors) of Localization (localization) of NF-kappaB

16) Confidence 0.33 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114486 Disease Relevance 0.31 Pain Relevance 0.11

In this study, we show that reducing ERK5 levels with a specific small hairpin RNA 5 (shERK5) reduced cell viability, sensitized cells to death receptor-induced apoptosis, and blocked the palliative effects of phorbol ester in anti-Fas Ab-treated cells. shERK5 decreased nuclear accumulation of the NF-kappaB p65 subunit, and conversely, ectopic activation of ERK5 led to constitutive nuclear localization of p65 and increased its ability to trans activate specific reporter genes.

Negative_regulation (decreased) of Localization (accumulation) of NF-kappaB associated with apoptosis, death and palliative

17) Confidence 0.32 Published 2006 Journal J. Immunol. Section Abstract Doc Link 17114430 Disease Relevance 0.44 Pain Relevance 0.10

Furthermore, our data also demonstrated that the translocation of NF-kappaB activated by LPS into the nucleus was suppressed by menthone, and I-kappaB and beta-transducin repeat containing protein (beta-TrCP) were both involved in this suppression.

Negative_regulation (suppressed) of Localization (translocation) of NF-kappaB in nucleus

18) Confidence 0.31 Published 2008 Journal Chin J Physiol Section Abstract Doc Link 18935911 Disease Relevance 0.66 Pain Relevance 0.29

All three salicylates inhibited the diabetes-induced translocation of p50 (a subunit of NF-kappaB) into nuclei of retinal vascular endothelial cells of the isolated retinal vasculature, as well as of p50 and p65 into nuclei of cells in the ganglion cell layer and inner nuclear layer on whole-retinal sections.

Negative_regulation (inhibited) of Localization (translocation) of p50 in ganglion cell layer associated with ganglion cysts and diabetes mellitus

19) Confidence 0.21 Published 2007 Journal Diabetes Section Abstract Doc Link 17259377 Disease Relevance 1.37 Pain Relevance 0.24

Certain NSAIDs, such as flurbiprofen and indomethacin, inhibit the nuclear translocation of the transcription factor NF-kB.

Negative_regulation (inhibit) of Localization (translocation) of NF-kB associated with cinod

20) Confidence 0.15 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2893374 Disease Relevance 0.24 Pain Relevance 0.27

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