INT71881

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Context Info
Confidence 0.45
First Reported 1997
Last Reported 2008
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.38
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
nucleus 4
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 22 95.20 Very High Very High Very High
withdrawal 18 94.84 High High
Morphine 12 94.40 High High
Potency 1 93.60 High High
ischemia 2 91.04 High High
cytokine 2 84.16 Quite High
cINOD 2 50.56 Quite High
Inflammatory response 3 47.00 Quite Low
Analgesic 2 25.00 Low Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 22 95.20 Very High Very High Very High
Hemophilus Infection 89 94.88 High High
Infection 12 83.92 Quite High
Death 1 75.72 Quite High
Shock 2 75.00 Quite High
Stroke 2 75.00 Quite High
Encephalitis 2 74.08 Quite High
Middle Cerebral Artery Infarction 1 53.76 Quite High
Brain Hemorrhage 2 50.12 Quite High
Skin Cancer 1 15.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Co-immunoprecipitation studies revealed an interaction of Hsp70 with NF-kappaB and IkappaBalpha, but not with IkappaB kinase, IKKgamma, suggesting that Hsp70 binds to the NF-kappaB:IkappaB complex preventing IkappaB phosphorylation by IKK.
Positive_regulation (preventing) of Phosphorylation (phosphorylation) of IkappaB
1) Confidence 0.45 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.71 Pain Relevance 0.26
Indeed, there are still increasing evidences that the blockade of MAPK inhibited NF-kappa B-dependent gene transcription without affecting IkappaBalpha phosphorylation and NF-kappa B-DNA binding ability [9,24-27].
Neg (without) Positive_regulation (without) of Phosphorylation (phosphorylation) of NF-kappa B-DNA
2) Confidence 0.20 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.29 Pain Relevance 0.04
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Positive_regulation (following) of Phosphorylation (phosphorylation) of IkappaB in nucleus
3) Confidence 0.05 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.82
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Positive_regulation (prevents) of Phosphorylation (phosphorylation) of IkappaB in nucleus
4) Confidence 0.05 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.83
NF-kappaB, which resides in an inactive, cytoplasmic complex in unstimulated cells, is activated by phosphorylation and degradation of its inhibitory subunit, IkappaB.
Positive_regulation (activated) of Phosphorylation (phosphorylation) of IkappaB
5) Confidence 0.02 Published 1997 Journal Biol. Chem. Section Abstract Doc Link 9348104 Disease Relevance 0.38 Pain Relevance 0.29

General Comments

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