INT71882

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Context Info
Confidence 0.81
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 20
Total Number 21
Disease Relevance 11.46
Pain Relevance 4.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
nucleus 3
spinal 1
osteoblast 1
A549 1
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Brush evoked pain 3 99.62 Very High Very High Very High
qutenza 3 95.96 Very High Very High Very High
agonist 4 95.56 Very High Very High Very High
Inflammation 58 95.20 Very High Very High Very High
Paracetamol 1 94.36 High High
withdrawal 10 94.32 High High
intrathecal 3 94.00 High High
Morphine 7 93.88 High High
Potency 1 93.08 High High
Dorsal horn 1 91.56 High High
Disease Link Frequency Relevance Heat
Hemophilus Infection 178 99.70 Very High Very High Very High
Neuropathic Pain 5 99.62 Very High Very High Very High
Apoptosis 163 99.52 Very High Very High Very High
Injury 28 99.10 Very High Very High Very High
INFLAMMATION 60 95.20 Very High Very High Very High
Osteoporosis 11 94.72 High High
Breast Cancer 1 92.96 High High
Cancer 6 92.64 High High
Hypoxia 53 92.52 High High
Cardiovascular Disease 3 92.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Additionally, there are other signaling factors that act more directly to activate NF-kappaB via IkappaB or by direct phosphorylation of NF-kappaB subunits.
Phosphorylation (phosphorylation) of NF-kappaB
1) Confidence 0.81 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14555789 Disease Relevance 1.01 Pain Relevance 0.23
This was associated with decreased phosphorylation of NF-kappaB inhibitor protein, IkappaBalpha, and decreased expression of several NFkappaB-regulated genes.
Phosphorylation (phosphorylation) of NF-kappaB
2) Confidence 0.74 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.88 Pain Relevance 0.29
Co-immunoprecipitation studies revealed an interaction of Hsp70 with NF-kappaB and IkappaBalpha, but not with IkappaB kinase, IKKgamma, suggesting that Hsp70 binds to the NF-kappaB:IkappaB complex preventing IkappaB phosphorylation by IKK.
Phosphorylation (phosphorylation) of IkappaB
3) Confidence 0.74 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.66 Pain Relevance 0.24
Additionally, there are other signaling factors that act more directly to activate NF-kappaB via IkappaB or by direct phosphorylation of NF-kappaB subunits.
Phosphorylation (phosphorylation) of IkappaB
4) Confidence 0.62 Published 2003 Journal Cardiovasc. Toxicol. Section Abstract Doc Link 14555789 Disease Relevance 1.02 Pain Relevance 0.24
Co-immunoprecipitation studies revealed an interaction of Hsp70 with NF-kappaB and IkappaBalpha, but not with IkappaB kinase, IKKgamma, suggesting that Hsp70 binds to the NF-kappaB:IkappaB complex preventing IkappaB phosphorylation by IKK.
Phosphorylation (phosphorylation) of IkappaB
5) Confidence 0.57 Published 2008 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 17473852 Disease Relevance 0.72 Pain Relevance 0.26
Overall, our results suggest that P(3)-25 exerts antitumorigenic activity by inhibiting phosphorylation of p65, the transcriptionally active subunit of NF-kappaB by inhibiting its upstream kinases, and potentiates apoptosis mediated by chemotherapeutic agents.
Phosphorylation (phosphorylation) of NF-kappaB associated with apoptosis
6) Confidence 0.46 Published 2007 Journal Cell Death Differ. Section Abstract Doc Link 16645640 Disease Relevance 0.53 Pain Relevance 0.07
Herein, we showed that NTHi activated the phosphorylation of p38 MAPK and nuclear translocation of NF-kappa B within 90 mins, and the enhanced DNA binding activity was observed in nuclear extracts of A549 cells after NTHi inoculation.
Phosphorylation (phosphorylation) of NF-kappa B in A549 associated with hemophilus infection
7) Confidence 0.36 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.15 Pain Relevance 0.12
Indeed, there are still increasing evidences that the blockade of MAPK inhibited NF-kappa B-dependent gene transcription without affecting IkappaBalpha phosphorylation and NF-kappa B-DNA binding ability [9,24-27].
Phosphorylation (phosphorylation) of NF-kappa B-DNA
8) Confidence 0.28 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 0.29 Pain Relevance 0.04
We performed Western blot analysis of the total protein lysate from the tissues of mouse PIN lesions to measure the level of expression of androgen receptor, vascular endothelial growth factor, nuclear factor-kappaB p65, BclII, AKT (total and phosphorylated Ser473), p53, cyclin-dependent kinase inhibitor p21WAF1/CIP1, p27, BAX, and caspase-3 to demonstrate the COX-2-independent mechanism involved in the inhibition of PIN lesions of the dorsolateral prostate by both celecoxib and exisulind.
Phosphorylation (phosphorylated) of nuclear factor-kappaB
9) Confidence 0.18 Published 2004 Journal Clin. Cancer Res. Section Body Doc Link 15570007 Disease Relevance 0.07 Pain Relevance 0
IL-1beta strongly increased the translocation of NF-kappaB to the nucleus and the phosphorylation of extracellular-signal-regulated kinase, p38, and c-Jun amino-terminal kinase; but the up-regulation was not inhibited by DEX or COX inhibitors.
Phosphorylation (phosphorylation) of NF-kappaB in nucleus
10) Confidence 0.11 Published 2009 Journal J Orthop Sci Section Body Doc Link 19802674 Disease Relevance 0.06 Pain Relevance 0
The expression of phosphorylated extracellular signal-regulated protein kinase 1/2 (pERK1/2), phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha (pCaMK-IIalpha) protein and phosphorylated IkappaB (pIkappaB) protein was increased by s.c. formalin injection at various time points.
Phosphorylation (phosphorylated) of pIkappaB
11) Confidence 0.08 Published 2008 Journal Neuroscience Section Abstract Doc Link 18329177 Disease Relevance 0.15 Pain Relevance 0.20
The expression of phosphorylated extracellular signal-regulated protein kinase 1/2 (pERK1/2), phosphorylated calcium/calmodulin-dependent protein kinase-IIalpha (pCaMK-IIalpha) protein and phosphorylated IkappaB (pIkappaB) protein was increased by s.c. formalin injection at various time points.
Phosphorylation (phosphorylated) of pIkappaB
12) Confidence 0.08 Published 2008 Journal Neuroscience Section Abstract Doc Link 18329177 Disease Relevance 0.15 Pain Relevance 0.20
Protein kinase A activation then prevents the phosphorylation and subsequent degradation of IkappaB, which in turn prevents translocation of the NF-kappaB p65 subunit to the nucleus to transactivate the IL-12 p40 gene, ultimately resulting in decreased IL-12 production following LPS stimulation.
Phosphorylation (phosphorylation) of IkappaB in nucleus
13) Confidence 0.08 Published 2008 Journal J. Immunol. Section Abstract Doc Link 18322172 Disease Relevance 0 Pain Relevance 0.82
Expression and phosphorylation of mitogen-activated protein kinases (MAPKs; JNK, ERK p44/42, and p38) and nuclear factor-kappa B (NF-?
Phosphorylation (phosphorylation) of nuclear factor-kappa B
14) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Abstract Doc Link PMC2089075 Disease Relevance 1.16 Pain Relevance 0
Lidocaine treatment resulted in decreased generation of phosphorylated IkappaB.
Phosphorylation (phosphorylated) of IkappaB
15) Confidence 0.05 Published 2010 Journal Immunobiology Section Body Doc Link 19559500 Disease Relevance 0.06 Pain Relevance 0
This effect is mediated by inhibition of NFkappaB activation via decreased IkappaB phosphorylation and is not mediated by lidocaine's effect on VGSC.


Phosphorylation (phosphorylation) of IkappaB
16) Confidence 0.05 Published 2010 Journal Immunobiology Section Body Doc Link 19559500 Disease Relevance 0 Pain Relevance 0
Intracellular and tissue levels of GPX1 activity affect apoptotic signaling pathway, protein kinase phosphorylation, and oxidant-mediated activation of NFkappaB.
Phosphorylation (phosphorylation) of NFkappaB associated with apoptosis
17) Confidence 0.04 Published 2007 Journal Annu. Rev. Nutr. Section Abstract Doc Link 17465855 Disease Relevance 0.97 Pain Relevance 0.13
TRAF-6 activates the protein kinase NFkB-Interacting Kinase (NIK), which phosphorylates the Inhibitor of IkB Kinase (IKK), thus leading to phosphorylation and degradation of IkB and translocation of NF-kB to the nucleus.
Phosphorylation (phosphorylation) of NF-kB in nucleus
18) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.43 Pain Relevance 0.03
NF-kappaB, which resides in an inactive, cytoplasmic complex in unstimulated cells, is activated by phosphorylation and degradation of its inhibitory subunit, IkappaB.
Phosphorylation (phosphorylation) of IkappaB
19) Confidence 0.03 Published 1997 Journal Biol. Chem. Section Abstract Doc Link 9348104 Disease Relevance 0.38 Pain Relevance 0.29
The functional inhibition of IL-18 signaling pathways suppressed injury-induced tactile allodynia and decreased the phosphorylation of nuclear factor kappaB in spinal astrocytes and the induction of astroglial markers.
Phosphorylation (phosphorylation) of nuclear factor kappaB in spinal associated with brush evoked pain and injury
20) Confidence 0.03 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 19036970 Disease Relevance 0.70 Pain Relevance 0.61

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