INT719

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Context Info
Confidence 0.57
First Reported 1978
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 96
Total Number 98
Disease Relevance 47.91
Pain Relevance 30.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SGCG) cytoskeleton (SGCG) cytoskeleton organization (SGCG)
cytoplasm (SGCG)
Anatomy Link Frequency
brain 2
blood 2
ECM 2
cartilage 2
T-lymphocytes 2
SGCG (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 55 100.00 Very High Very High Very High
Dopamine 25 100.00 Very High Very High Very High
gABA 22 100.00 Very High Very High Very High
antagonist 16 100.00 Very High Very High Very High
Morphine 15 100.00 Very High Very High Very High
Serotonin 12 100.00 Very High Very High Very High
qutenza 11 100.00 Very High Very High Very High
monoamine 8 100.00 Very High Very High Very High
Cholecystokinin 4 100.00 Very High Very High Very High
Botox 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Headache 79 100.00 Very High Very High Very High
Cold Sores 70 100.00 Very High Very High Very High
Diabetes Mellitus 21 100.00 Very High Very High Very High
Heart Rate Under Development 12 100.00 Very High Very High Very High
Starvation 1 100.00 Very High Very High Very High
Cv General 3 Under Development 20 99.92 Very High Very High Very High
Hereditary Angioedema 7 99.88 Very High Very High Very High
Down Syndrome 3 99.88 Very High Very High Very High
Coronary Heart Disease 5 99.86 Very High Very High Very High
Decompression Sickness 10 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cilostazol, an inhibitor of phosphodiesterase (PDE) type 3, is used clinically in peripheral artery disease.
Negative_regulation (inhibitor) of type in artery associated with peripheral arterial disease
1) Confidence 0.57 Published 2004 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 15625409 Disease Relevance 0.28 Pain Relevance 0.04
Transfection with beta gamma subunit cDNAs did not affect dopamine stimulation of type V adenylyl cyclase activity, and morphine-induced inhibition of type V adenylyl cyclase activity was still evident in cells cotransfected with the alpha subunit of transducin.
Negative_regulation (inhibition) of type associated with dopamine and morphine
2) Confidence 0.57 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700117 Disease Relevance 0.07 Pain Relevance 0.70
Reduction in the duration of apnea was observed after selective inhibition of central gamma-aminobutyric acid (GABA) type A receptors and neurokinin type 1 receptors for substance P.
Negative_regulation (inhibition) of type associated with gaba, sleep disorders and substance p
3) Confidence 0.57 Published 2005 Journal Pediatr. Res. Section Abstract Doc Link 15774838 Disease Relevance 1.98 Pain Relevance 0.42
The concomitant addition of morphine produced a dose-dependent inhibition of dopamine-stimulated type V adenylyl cyclase activity.
Negative_regulation (inhibition) of type associated with dopamine and morphine
4) Confidence 0.57 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8700117 Disease Relevance 0.07 Pain Relevance 0.82
The first type receptors are not present on murine brain cells nor are inhibited by naloxone.
Negative_regulation (inhibited) of type in brain associated with narcan
5) Confidence 0.57 Published 1996 Journal Immunol. Lett. Section Abstract Doc Link 8964604 Disease Relevance 0 Pain Relevance 0.24
Acquired type II protein C deficiency in a long-term hemodialysis patient.
Negative_regulation (deficiency) of type associated with cva
6) Confidence 0.57 Published 1994 Journal Nephron Section Title Doc Link 8190190 Disease Relevance 0.37 Pain Relevance 0.14
Although differing in potency, the inhibition of both wild-type alpha3beta4 receptors and alpha3beta4(6'F10'T) receptors by QX-314 is voltage-dependent and noncompetitive.
Negative_regulation (inhibition) of type associated with potency
7) Confidence 0.57 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11723244 Disease Relevance 0 Pain Relevance 0.35
Responses to intravenous clonidine, a possible central noradrenergic probe, were examined in patients with depression before and after treatment with clorgiline, a selective monoamine oxidase type A inhibitor.
Negative_regulation (inhibitor) of type associated with depression, monoamine and clonidine
8) Confidence 0.57 Published 1988 Journal Clin. Pharmacol. Ther. Section Abstract Doc Link 2826065 Disease Relevance 0.18 Pain Relevance 0.28
However, whereas the onset of inhibition of wild-type alpha3beta4 receptors is voltage-dependent and noncompetitive, the onset of inhibition of alpha3beta4(6'F10'T) receptors by tetracaine is unaffected by membrane voltage, and at concentrations < or = 30 microM seems to be competitive with acetylcholine.
Negative_regulation (inhibition) of type
9) Confidence 0.57 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11723244 Disease Relevance 0 Pain Relevance 0.37
[Selective inhibitors of type 2 cyclooxygenase: less renal effects than the classical non-steroidal anti-inflammatory agents].
Negative_regulation (inhibitors) of type associated with inflammation and cox2
10) Confidence 0.57 Published 2000 Journal Nephrologie Section Title Doc Link 11213386 Disease Relevance 0.51 Pain Relevance 0.65
Thus, we wished to determine whether 5-hydroxytryptamine type 3 receptor blockade slows colonic and small bowel transit in patients with diarrhea-predominant irritable bowel syndrome (IBS) and whether symptoms would be ameliorated with drug therapy.
Negative_regulation (blockade) of type in bowel associated with diarrhoea and spastic colon
11) Confidence 0.57 Published 1992 Journal Mayo Clin. Proc. Section Abstract Doc Link 1434911 Disease Relevance 0.34 Pain Relevance 0.40
Type I protein C deficiency was demonstrated in this patient as well as in his asymptomatic sister.
Negative_regulation (deficiency) of Type
12) Confidence 0.57 Published 1992 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 1568546 Disease Relevance 0.71 Pain Relevance 0.26
The clinical availability of new drugs able to produce a selective inhibition of type 2 cyclooxygenase (COX-2), the enzyme thought to be mainly responsible for generating arachidonic-acid-derived inflammatory mediators, has been the origin of much hope.
Negative_regulation (inhibition) of type associated with inflammatory mediators
13) Confidence 0.57 Published 2001 Journal Pharmacol. Res. Section Abstract Doc Link 11394934 Disease Relevance 0.35 Pain Relevance 0.32
Mobitz type II block continued, but blood pressure and heart rate were maintained during the operation.
Negative_regulation (block) of type in blood
14) Confidence 0.42 Published 2010 Journal Masui Section Abstract Doc Link 20229756 Disease Relevance 0.11 Pain Relevance 0.48
Cilostazol, a type III phosphodiesterase inhibitor, was approved in the United States in 1999 for the reduction of the symptoms of intermittent claudication.
Negative_regulation (inhibitor) of type associated with restless leg syndrome
15) Confidence 0.42 Published 2001 Journal Am. J. Cardiol. Section Abstract Doc Link 11434897 Disease Relevance 0.21 Pain Relevance 0.16
We examined the effect of cilostazol, a type III phosphodiesterase inhibitor, on pain-free and maximal walking distance and quality of life measures.
Negative_regulation (inhibitor) of type associated with pain
16) Confidence 0.42 Published 2002 Journal Am. J. Cardiol. Section Abstract Doc Link 12480040 Disease Relevance 0.45 Pain Relevance 0.31
These data suggest that small doses of a phosphodiesterase type 5 inhibitor may be a useful adjunct to inhaled iloprost in the management of pulmonary hypertension.


Negative_regulation (inhibitor) of type
17) Confidence 0.42 Published 2001 Journal Circulation Section Body Doc Link 11551870 Disease Relevance 0 Pain Relevance 0
Another new approach to migraine prevention is angiotensin type 1 (AT1) receptor blockade.
Negative_regulation (blockade) of type associated with migraine
18) Confidence 0.42 Published 2004 Journal Annu. Rev. Med. Section Abstract Doc Link 14746533 Disease Relevance 0.75 Pain Relevance 0.76
Vardenafil: a novel type 5 phosphodiesterase inhibitor for the treatment of erectile dysfunction.
Negative_regulation (inhibitor) of type associated with reprotox - general 2
19) Confidence 0.42 Published 2004 Journal Expert Opin Pharmacother Section Title Doc Link 15102574 Disease Relevance 0.59 Pain Relevance 0.03
It has been reported that tramadol inhibits muscarinic type 3 receptor function, which primarily mediates smooth muscle contraction and glandular secretion.
Negative_regulation (inhibits) of type in smooth muscle associated with tramadol
20) Confidence 0.42 Published 2004 Journal Can J Anaesth Section Abstract Doc Link 15197115 Disease Relevance 0 Pain Relevance 0.70

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