INT7190

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Context Info
Confidence 0.16
First Reported 1992
Last Reported 1992
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 3.23

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peptidase activity (Ctsb) mitochondrion (Ctsb) extracellular space (Ctsb)
extracellular region (Ctsb) response to stress (Ctsb) lysosome (Ctsb)
Syt17 (Rattus norvegicus)
Ctsb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 69 100.00 Very High Very High Very High
antagonist 6 97.48 Very High Very High Very High
Enkephalin 18 93.48 High High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results indicate that phospholipase C and serine/threonine kinases are involved in the activation of cathepsin B by BK, des-Arg9-BK or L-Arg.
des-Arg9-BK Positive_regulation (activation) of cathepsin B associated with bradykinin
1) Confidence 0.16 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.04
Genistein inhibited the activation of cathepsin B by des-Arg9-BK or L-Arg in a different fashion, suggesting that tyrosine kinase(s) is also involved in the activation.
des-Arg9-BK Positive_regulation (activation) of cathepsin B associated with bradykinin
2) Confidence 0.16 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 0.98
The activation of cathepsin B by BK or des-Arg9-BK was inhibited by des-Arg9-[Leu8]-BK or islet-activating protein (IAP), and the activation of cathepsin B by L-Arg was inhibited by Leu-Arg (kyotorphin-receptor antagonist) or Botulinum C3-enzyme.
des-Arg9-BK Positive_regulation (activation) of cathepsin B associated with antagonist and bradykinin
3) Confidence 0.16 Published 1992 Journal J Osaka Univ Dent Sch Section Abstract Doc Link 1341708 Disease Relevance 0 Pain Relevance 1.21

General Comments

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