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Context Info
Confidence 0.34
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.79
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1, PGR) enzyme binding (ESR1, PGR) DNA binding (ESR1, PGR)
cytoplasm (ESR1, PGR) signal transduction (ESR1, PGR) nucleus (ESR1, PGR)
ESR1 (Homo sapiens)
PGR (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 15 96.96 Very High Very High Very High
agonist 18 72.12 Quite High
imagery 4 50.04 Quite High
antagonist 29 42.44 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
endometriosis 3 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
sSRI 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 280 100.00 Very High Very High Very High
Cancer 187 100.00 Very High Very High Very High
Metastasis 34 99.88 Very High Very High Very High
Aggression 6 96.84 Very High Very High Very High
Disease 65 94.44 High High
Reprotox - General 1 63 92.08 High High
Advanced Or Metastatic Breast Cancer 10 85.20 High High
Uterine Fibroids 21 85.12 High High
Recurrence 37 83.44 Quite High
Carcinoma 10 79.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
All 21 metastases were negative for ER and PR on immunohistochemistry.
ER Binding (negative) of PR associated with metastasis
1) Confidence 0.34 Published 1997 Journal J. Pathol. Section Abstract Doc Link 9349240 Disease Relevance 0.57 Pain Relevance 0.10
Subgroups were classified on the basis of ER, PR, and HER2 IHC findings with 71 of the 110 patients (64.5%) being HR+, 14 patients (12.7%) HER2+, and 25 patients (22.7%) TN.
ER Binding (findings) of PR
2) Confidence 0.26 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2972282 Disease Relevance 0.62 Pain Relevance 0.11
/PR-positive breast cancer was associated with longer overall survival (70% for high ER?
ER Binding (associated) of PR-positive associated with breast cancer
3) Confidence 0.14 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.74 Pain Relevance 0
These models also showed that PR modulation results in a complex interaction with ER- and AR-mediated responses.
ER Binding (interaction) of PR
4) Confidence 0.09 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1775068 Disease Relevance 0.34 Pain Relevance 0.06
Patients who have ER-positive tumours with unfavourable characteristics, such as HER-2 positivity, PgR negativity or nodal positivity, are likely to be selected for immediate AI therapy.
ER Neg (negativity) Binding (negativity) of PgR associated with cancer
5) Confidence 0.04 Published 2007 Journal International Journal of Clinical Practice Section Body Doc Link PMC2228389 Disease Relevance 0.66 Pain Relevance 0
For example, breast carcinomas that are ER-negative, PR-negative, and do not have HER2 over expressed (triple negative) are marked by aggressive behavior, but because women with triple-negative disease are not eligible for tamoxifen or trastuzumab treatment, they usually have relatively low long-term survival [92].
ER Binding (negative) of PR associated with aggression, breast cancer and disease
6) Confidence 0.04 Published 2010 Journal Current Genomics Section Body Doc Link PMC2878980 Disease Relevance 0.86 Pain Relevance 0

General Comments

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