INT71916

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 16
Disease Relevance 1.69
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TTN) extracellular region (TTN) nucleus (TTN)
enzyme binding (TTN) cytoplasm (TTN)
Anatomy Link Frequency
Notch 1
muscle 1
cleavage 1
anatomical structure 1
skeletal muscles 1
TTN (Homo sapiens)
Pain Link Frequency Relevance Heat
Snapping jaw 36 99.48 Very High Very High Very High
addiction 8 99.28 Very High Very High Very High
agonist 54 98.28 Very High Very High Very High
sodium channel 1 89.92 High High
Face pain 22 89.88 High High
Pain 41 79.04 Quite High
cINOD 11 58.28 Quite High
imagery 10 53.24 Quite High
Myofascial pain syndrome 17 50.00 Quite Low
tetrodotoxin 2 34.24 Quite Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Disorders 92 100.00 Very High Very High Very High
Temporomandibular Joint Syndrome 36 99.48 Very High Very High Very High
Alzheimer's Dementia 40 91.44 High High
Facial Pain 24 89.88 High High
Sprains And Strains 33 71.60 Quite High
Pain 32 58.56 Quite High
INFLAMMATION 11 58.04 Quite High
Dislocations 3 54.44 Quite High
Congenital Anomalies 34 50.00 Quite Low
Arthralgia 1 6.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Markers for differentiated muscle, such as the muscle isoform of creatine kinase and the cytoskeletal proteins alpha-actinin, alpha-sarcomeric actin, myosin and titin were present in early stages.
Gene_expression (present) of titin in muscle
1) Confidence 0.75 Published 1997 Journal J. Muscle Res. Cell. Motil. Section Abstract Doc Link 9350011 Disease Relevance 0 Pain Relevance 0.04
One construct has its transmembrane domain (TMD) replaced by the Notch TMD (APP-m-NOTCH) and the other with the juxtamembrane portion of the APP ectodomain (the ?
Gene_expression (replaced) of TMD in Notch
2) Confidence 0.65 Published 2008 Journal Mol Brain Section Body Doc Link PMC2637266 Disease Relevance 0 Pain Relevance 0
Moreover, it is considered to be very important to define the morphologic and functional changes in the anatomical structure of the TMJ region and to follow the progression of TMD based on the clinical manifestations observed upon MRI in patients with TMD.
Gene_expression (progression) of TMD in anatomical structure associated with snapping jaw and temporomandibular joint disorders
3) Confidence 0.29 Published 2009 Journal The Open Dentistry Journal Section Body Doc Link PMC2703205 Disease Relevance 0.98 Pain Relevance 0.26
As regards the 2 × 2 matrix diagnostic model, clearly, there may be clinical situations in which several symptoms caused by different pathologies overlap as in the concomitant presence of TMD and organic trigeminal damage.
Gene_expression (presence) of TMD associated with temporomandibular joint disorders
4) Confidence 0.21 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2909162 Disease Relevance 0.42 Pain Relevance 0.25
The current TMD simulation was initiated from a homology model of the human ?
Gene_expression (simulation) of TMD
5) Confidence 0.12 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1584325 Disease Relevance 0 Pain Relevance 0.03
In our TMD simulation, the entire loop tended to move closer to ?
Gene_expression (simulation) of TMD
6) Confidence 0.12 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1584325 Disease Relevance 0 Pain Relevance 0.05
In the current TMD simulation, this interaction seemed essential to mediate the concerted motion of the ?
Gene_expression (simulation) of TMD
7) Confidence 0.12 Published 2006 Journal PLoS Computational Biology Section Body Doc Link PMC1584325 Disease Relevance 0 Pain Relevance 0.08
Comparing the force in passive and chemically activated fibers would explain whether this difference is due to a shorter titin protein in extraocular muscles (in which case the single fiber total stiffness would also be always positive), or whether it is in fact the collagen surrounding the fibers that provides most of the passive force in whole extraocular muscle (in which case the single fiber total stiffness would be similar to that observed in skeletal muscles).
Gene_expression (protein) of titin in skeletal muscles
8) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2660417 Disease Relevance 0 Pain Relevance 0
Moreover, although Spitz-TMD and Keren-TMD display high sequence homology, Spitz-TMD was poorly processed compared to Keren-TMD.
Gene_expression (processed) of TMD
9) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0 Pain Relevance 0.05
The TMD region of APP695 was cloned from a synthetic duplex DNA fragment.
Gene_expression (region) of TMD
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0.07 Pain Relevance 0
Moreover, although Spitz-TMD and Keren-TMD display high sequence homology, Spitz-TMD was poorly processed compared to Keren-TMD.
Gene_expression (processed) of TMD
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0 Pain Relevance 0.05
The chimeric protein substrates used for the in vitro activity assay contained the predicted TMD region of the 695-amino acid long isoform of APP (?
Gene_expression (region) of TMD
12) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0 Pain Relevance 0
Incubation of MCMJR1 with the substrates Gurken-TMD and Keren-TMD, in the presence of amino-peptidase (bestatin) and cysteine/serine protease (E-64/PMSF) inhibitors, produced a ?
Gene_expression (produced) of TMD
13) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0 Pain Relevance 0.04
To map the profile of this cleavage, we designed a chimeric substrate (APP-TMD) containing the TMD of APP fused to MBP.
Gene_expression (containing) of TMD in cleavage
14) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0.07 Pain Relevance 0
Moreover, although Spitz-TMD and Keren-TMD display high sequence homology, Spitz-TMD was poorly processed compared to Keren-TMD.
Gene_expression (processed) of TMD
15) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0 Pain Relevance 0.05
-Secretase cleaves at multiple sites within the TMD of its physiological substrate ?
Gene_expression (sites) of TMD
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0.15 Pain Relevance 0.06

General Comments

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