INT71918

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 16
Total Number 19
Disease Relevance 7.73
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (ACTA1) cytoplasm (ACTA1)
Anatomy Link Frequency
muscle 2
vessels 2
smooth muscle 1
liver 1
fibroblasts 1
ACTA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 100 99.50 Very High Very High Very High
imagery 130 98.72 Very High Very High Very High
Kinase C 7 96.08 Very High Very High Very High
cytokine 24 93.40 High High
sodium channel 1 89.92 High High
fibrosis 30 89.76 High High
ischemia 3 89.08 High High
Osteoarthritis 27 70.56 Quite High
Inflammation 81 55.24 Quite High
Pain 9 50.00 Quite Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 93 99.50 Very High Very High Very High
Carcinoma 3 99.28 Very High Very High Very High
Channelopathies 5 99.12 Very High Very High Very High
Muscle Disease 51 97.92 Very High Very High Very High
Renal Cancer 10 96.20 Very High Very High Very High
Infection 153 94.44 High High
Rickettsiaceae Infection 54 91.12 High High
Injury 25 90.32 High High
Fibrosis 35 89.76 High High
Cv Unclassified Under Development 7 89.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time the pathogen is released from the phagosome, it induces the expression of ActA, a protein that triggers the nucleation and polymerization of host globular g-actin into f-actin filaments.
Gene_expression (expression) of ActA in filaments
1) Confidence 0.75 Published 2010 Journal International Journal of Inflammation Section Body Doc Link PMC3003996 Disease Relevance 0.06 Pain Relevance 0
Typical muscle imaging findings of patients with proven mutations in the DNM2, SEPN1, ACTA1, RYR1 and collagen 6A1 are provided

Muscle channelopathies and metabolic myopathies

Gene_expression (6A1) of ACTA1 in muscle associated with muscle disease, channelopathies and imagery
2) Confidence 0.47 Published 2010 Journal Eur Radiol Section Body Doc Link PMC2940021 Disease Relevance 0.99 Pain Relevance 0.13
The genes that encode the key virulence factors PlcA, LLO, ActA, and PlcB are clustered in a 10?
Gene_expression (encode) of ActA
3) Confidence 0.29 Published 2010 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2829626 Disease Relevance 0.05 Pain Relevance 0
INTERVENTION(S): Immunohistochemical staining of endometriotic specimens for alpha-smooth muscle actin (ASMA), neural cell adhesion molecule (NCAM), and nerve growth factor (NGF) expression.
Gene_expression (expression) of ASMA in neural
4) Confidence 0.17 Published 2009 Journal Fertil. Steril. Section Body Doc Link 18930216 Disease Relevance 0.14 Pain Relevance 0
MAIN OUTCOME MEASURE(S): Comparison of the immunoreactive staining of ASMA, NCAM, and NGF expression in human endometriosis and a rat endometriosis model.
Gene_expression (expression) of ASMA
5) Confidence 0.15 Published 2009 Journal Fertil. Steril. Section Body Doc Link 18930216 Disease Relevance 0.13 Pain Relevance 0
Concomitantly, addition of BMP-7 stimulates the expression of SMC-specific markers, namely alpha-actin and heavy chain myosin as examined by RT-PCR and Northern blot analyses.
Spec (analyses) Gene_expression (expression) of alpha-actin
6) Confidence 0.13 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10825232 Disease Relevance 0 Pain Relevance 0
Sections of rat liver, kidney or stomach (BioSystems, Sp) were used as a substrate to detect specific antibodies (anti-parietal cell, PCA, and anti-smooth muscle, ASMA).
Gene_expression (parietal cell) of ASMA in kidney
7) Confidence 0.11 Published 2005 Journal J Autoimmune Dis Section Body Doc Link PMC1298324 Disease Relevance 0.76 Pain Relevance 0
One patient had antibodies to dsDNA and three had ANCA or ANA but only ASMA and CMA were detectable in a significant number of patients (29.2 % and 12.1% respectively).
Gene_expression (detectable) of ASMA
8) Confidence 0.10 Published 2005 Journal J Autoimmune Dis Section Body Doc Link PMC1298324 Disease Relevance 0.46 Pain Relevance 0
Markers for differentiated muscle, such as the muscle isoform of creatine kinase and the cytoskeletal proteins alpha-actinin, alpha-sarcomeric actin, myosin and titin were present in early stages.
Gene_expression (present) of alpha-sarcomeric actin in muscle
9) Confidence 0.09 Published 1997 Journal J. Muscle Res. Cell. Motil. Section Abstract Doc Link 9350011 Disease Relevance 0 Pain Relevance 0.04
Sections of rat liver, kidney or stomach (BioSystems, Sp) were used as a substrate to detect specific antibodies (anti-parietal cell, PCA, and anti-smooth muscle, ASMA).
Gene_expression (parietal cell) of ASMA in liver
10) Confidence 0.04 Published 2005 Journal J Autoimmune Dis Section Body Doc Link PMC1298324 Disease Relevance 0.76 Pain Relevance 0
Podoplanin immunoperoxidase and CD31 immunofluorescent labelling were mutually exclusive, therefore confirming that in RA synovial tissues, CD31+/aSMA- were immature blood vessels (Figure 2).


Gene_expression (blood vessels) of aSMA in blood vessels associated with arthritis
11) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779850 Disease Relevance 0.76 Pain Relevance 0.24
Although erythrocytes could be observed in some immature vessels lumen by light phase contrast microscopy (data not shown), to formally exclude that increased lymphatics in RA could explain the presence of CD31 vessels lacking aSMA-positive periendothelial cells, we performed double CD31 and lymphatic (podoplanin) immunolabelling.
Neg (lacking) Gene_expression (lacking) of aSMA in lumen associated with arthritis
12) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779850 Disease Relevance 0.54 Pain Relevance 0.24
Interobserver correlation coefficient for CD31+/aSMA- number of vessels was r?
Gene_expression (/) of aSMA in vessels
13) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779850 Disease Relevance 0 Pain Relevance 0
To examine calponin expression and structural changes of periglomerular calponin-positive glomeruli, five serial tissue sections were stained with periodic acid-methenamine silver (PAMS), alpha-smooth muscle actin (ASMA) antiserum, calponin antiserum, vimentin antiserum, and the periodic acid-Schiff (PAS) method.
Spec (examine) Gene_expression (expression) of ASMA in smooth muscle
14) Confidence 0.02 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0 Pain Relevance 0
Myofibroblasts are usually immunostained using several specific markers, such as alpha-smooth muscle actin (ASMA), vimentin, and calponin in several tissues (Frangogiannis et al., 2000; Chen et al., 2009; Ferguson et al., 2009) However, to the authors' knowledge there has been no report of calponin expression in renal myofibroblasts, while calponin expression in the renal vessels, mesangial cells, and renal tumor cells has been reported (Islam et al., 2004a & b).
Gene_expression (expression) of ASMA in mesangial cells associated with renal cancer
15) Confidence 0.02 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.85 Pain Relevance 0.21
Myofibroblasts express the mesenchymal marker ASMA and share features of both fibroblasts and smooth muscle cells.
Gene_expression (express) of ASMA in smooth muscle cells
16) Confidence 0.02 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.56 Pain Relevance 0.03
Northern analysis was performed to examine cardiac expression of mRNAs encoding alpha-actin and myosin heavy chain (MHC) isoforms.
Spec (examine) Gene_expression (expression) of alpha-actin
17) Confidence 0.01 Published 1999 Journal Am. J. Physiol. Section Abstract Doc Link 10233047 Disease Relevance 0.26 Pain Relevance 0.30
Myofibroblasts are usually immunostained using several specific markers, such as alpha-smooth muscle actin (ASMA), vimentin, and calponin in several tissues (Frangogiannis et al., 2000; Chen et al., 2009; Ferguson et al., 2009) However, to the authors' knowledge there has been no report of calponin expression in renal myofibroblasts, while calponin expression in the renal vessels, mesangial cells, and renal tumor cells has been reported (Islam et al., 2004a & b).
Gene_expression (expression) of ASMA in vessels associated with renal cancer
18) Confidence 0.01 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.85 Pain Relevance 0.21
Myofibroblasts express the mesenchymal marker ASMA and share features of both fibroblasts and smooth muscle cells.
Gene_expression (express) of ASMA in fibroblasts
19) Confidence 0.01 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998789 Disease Relevance 0.56 Pain Relevance 0.03

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