INT71933

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Context Info
Confidence 0.56
First Reported 1997
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 14.24
Pain Relevance 2.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F2) extracellular space (F2) extracellular region (F2)
plasma membrane (F2)
Anatomy Link Frequency
blood 8
platelet 6
chest 4
plasma 2
macrophages 2
F2 (Homo sapiens)
F2 - G20210A (1)
Pain Link Frequency Relevance Heat
spastic colon 29 99.52 Very High Very High Very High
alcohol 1 99.00 Very High Very High Very High
cva 133 96.84 Very High Very High Very High
Restless leg syndrome 61 96.04 Very High Very High Very High
Inflammation 173 90.24 High High
cytokine 162 89.20 High High
Inflammatory mediators 4 87.76 High High
Pain 66 86.68 High High
corticosteroid 28 84.48 Quite High
Angina 26 82.32 Quite High
Disease Link Frequency Relevance Heat
Thrombocytopenia 8 100.00 Very High Very High Very High
Systemic Lupus Erythematosus 7 100.00 Very High Very High Very High
Myocardial Infarction 137 99.84 Very High Very High Very High
Disseminated Intravascular Coagulation 10 99.66 Very High Very High Very High
Diabetes Mellitus 122 99.60 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

25 99.52 Very High Very High Very High
Hyperglycemia 75 99.34 Very High Very High Very High
Thrombophilia 232 99.14 Very High Very High Very High
Alcohol Addiction 1 99.12 Very High Very High Very High
Vasculitis 18 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Augmented local thrombin production in myocardial infarction patients with glucose >7.0 mmol/l was accompanied by increased platelet activation, reflected by elevated sCD40L levels in venous plasma and bleeding time blood.
Positive_regulation (Augmented) of Gene_expression (production) of thrombin in blood associated with hemorrhage and myocardial infarction
1) Confidence 0.56 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 0.99 Pain Relevance 0
We used the following definitions: cardiac failure was defined as requiring use of inotropic agents; respiratory failure was defined as the need for assisted ventilatiory support; ARDS was defined as clinical deterioration with severe arterial hypoxaemia and diffuse bilateral infiltrates on chest radiograph; disseminated intravenous coagulation (DIC) was defined as elevated prothrombin time (PT) with elevated activated partial thromboplastin time (APTT), and decreased fibrinogen (FIB) level with thrombocytopenia; liver function impairment was defined as aminotransferase (ALT or AST) levels ?
Positive_regulation (as) of Gene_expression (time) of prothrombin in chest associated with respiratory failure, thrombocytopenia, disseminated intravascular coagulation, adult respiratory distress syndrome and myocardial infarction
2) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.58 Pain Relevance 0.08
The following data were collected from the Institutional Database or direct analysis of the perfusion files: demographics: age (months), weight (kg), gender; type of surgical operation with Aristotle complexity score [16]; preoperative laboratory data: hematocrit (percentage), platelet count (cells/microliter), prothrombin time (seconds), activated partial thromboplastin time (seconds), antithrombin (percentage), serum creatinine value (milligrams per deciliter); CPB data: CPB duration (minutes), lowest temperature on CPB (degrees Centigrade), use of blood prime, ScVO2 values (percentage), and lactate values (mmol/L).
Spec (partial) Positive_regulation (activated) of Gene_expression (time) of prothrombin in blood
3) Confidence 0.49 Published 2010 Journal Crit Care Section Body Doc Link PMC2945132 Disease Relevance 0 Pain Relevance 0
We used the following definitions: cardiac failure was defined as requiring use of inotropic agents; respiratory failure was defined as the need for assisted ventilatiory support; ARDS was defined as clinical deterioration with severe arterial hypoxaemia and diffuse bilateral infiltrates on chest radiograph; disseminated intravenous coagulation (DIC) was defined as elevated prothrombin time (PT) with elevated activated partial thromboplastin time (APTT), and decreased fibrinogen (FIB) level with thrombocytopenia; liver function impairment was defined as aminotransferase (ALT or AST) levels ?
Spec (partial) Positive_regulation (elevated) of Gene_expression (time) of prothrombin in chest associated with respiratory failure, thrombocytopenia, disseminated intravascular coagulation, adult respiratory distress syndrome and myocardial infarction
4) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2515635 Disease Relevance 0.61 Pain Relevance 0.07
This condition develops as the result of the formation of antibodies to the heparin-platelet factor 4 complex, which causes secondary activation of platelets, coagulation, and ultimately increased thrombin production.33
Positive_regulation (increased) of Gene_expression (production.33) of thrombin in platelets
5) Confidence 0.48 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2879296 Disease Relevance 1.06 Pain Relevance 0.04
Hypercoagulability develops in septic patients, resulting in enhanced thrombin generation, thrombin activation, and fibrin formation.
Positive_regulation (enhanced) of Gene_expression (generation) of thrombin associated with thrombophilia
6) Confidence 0.46 Published 2006 Journal Crit Care Section Body Doc Link PMC1794466 Disease Relevance 0.73 Pain Relevance 0.09
Our results show that unfractionated and low molecular weight heparins potently inhibit monocytic tissue factor induced thrombin generation.
Positive_regulation (induced) of Gene_expression (generation) of thrombin
7) Confidence 0.40 Published 1999 Journal Haemostasis Section Abstract Doc Link 10844403 Disease Relevance 0 Pain Relevance 0.08
Acute hyperglycemia activates platelet aggregation, enhances thrombin generation, and activates coagulation factor VII (9).
Positive_regulation (enhances) of Gene_expression (generation) of thrombin in platelet associated with hyperglycemia
8) Confidence 0.38 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.64 Pain Relevance 0.14
In summary, our findings demonstrate that acute hyperglycemia in acute myocardial infarction patients without a previous history of diabetes is associated with increased thrombin generation and platelet activation at the site of vascular injury as well as greater resistance to fibrinolysis.
Positive_regulation (increased) of Gene_expression (generation) of thrombin in platelet associated with hyperglycemia, diabetes mellitus, vasculitis and myocardial infarction
9) Confidence 0.38 Published 2008 Journal Diabetes Care Section Body Doc Link PMC2494657 Disease Relevance 1.00 Pain Relevance 0
Hypercoagulability develops in septic patients, resulting in enhanced thrombin generation, thrombin activation, and fibrin formation.
Positive_regulation (enhanced) of Gene_expression (generation) of thrombin associated with thrombophilia
10) Confidence 0.33 Published 2006 Journal Crit Care Section Body Doc Link PMC1794466 Disease Relevance 0.74 Pain Relevance 0.09
The prothrombin mutation is associated with elevated plasma prothrombin levels (factor II activity >130 percent) and is present in about 2–5 percent of healthy individuals.
Positive_regulation (elevated) of Gene_expression (levels) of prothrombin in plasma
11) Confidence 0.25 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305329 Disease Relevance 0.54 Pain Relevance 0.13
Prostacyclin production in tryptase and thrombin stimulated human bladder endothelial cells: effect of pretreatment with phospholipase A2 and cyclooxygenase inhibitors.
Positive_regulation (stimulated) of in endothelial cells Gene_expression (production) of thrombin in bladder
12) Confidence 0.18 Published 2006 Journal J. Urol. Section Title Doc Link 16952710 Disease Relevance 0.25 Pain Relevance 0.17
Real time RT-PCR analysis of thrombin treated collagen embedded hUtSMC mRNA
Positive_regulation (treated) of Gene_expression (analysis) of thrombin
13) Confidence 0.14 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2645409 Disease Relevance 0 Pain Relevance 0
Frequent risk factors include trauma, steroid therapy or hypercortisonism [2-4], alcohol abuse and different coagulopathies, for example, activated protein C (APC) resistance, protein S deficiency, prothrombin mutations and hyperhomocysteinaemia [5,6].
Positive_regulation (activated) of Gene_expression (resistance) of prothrombin associated with injury and alcohol
14) Confidence 0.07 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592809 Disease Relevance 2.45 Pain Relevance 0.20
This increased lipid accumulation was accompanied by enhanced expression of tissue factor and plasminogen activator inhibitor-1, as well as enhanced thrombin formation, transforming macrophages into a prothrombotic phenotype.
Positive_regulation (enhanced) of Gene_expression (expression) of thrombin in macrophages
15) Confidence 0.06 Published 2005 Journal Circulation Section Body Doc Link 16186421 Disease Relevance 0 Pain Relevance 0
Therefore protein C activation will be correspondingly low, and the negative feedback that controls TNF-induced thrombin formation correspondingly weak (Figure 1a), further enhancing concentrations of the above adhesion molecules.
Positive_regulation (induced) of Gene_expression (formation) of thrombin associated with adhesions
16) Confidence 0.06 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.54 Pain Relevance 0.20
Tissue factor is a membrane-bound glycoprotein that functions in the extrinsic pathway of blood coagulation by acting as a cofactor for factor VII, and the resulting complex leads to thrombin production in vivo.
Positive_regulation (leads) of Gene_expression (production) of thrombin in blood
17) Confidence 0.05 Published 1997 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 9351394 Disease Relevance 0.58 Pain Relevance 0.49
Four factors were considered to increase the angiogenic potential of the PRP, including the concentrations of thrombin and calcium for platelet activation, the subsequent release of vascular endothelial growth factor (VEGF), production of platelet microparticles (PMPs), and inclusion of only peripheral blood mononuclear cells (PBMNCs) among white blood cells (WBCs).
Positive_regulation (increase) of Gene_expression (production) of thrombin in blood
18) Confidence 0.05 Published 2010 Journal The Journal of Advanced Prosthodontics Section Body Doc Link PMC2984511 Disease Relevance 0.07 Pain Relevance 0
To date, two studies have found an increase in thrombin generation following exercise, and only one of these showed an increase in fibrin breakdown in patients with IC who were not on statin therapy.
Positive_regulation (increase) of Gene_expression (generation) of thrombin associated with restless leg syndrome
19) Confidence 0.03 Published 2006 Journal Thromb J Section Body Doc Link PMC1540420 Disease Relevance 0.49 Pain Relevance 0.27
In one study, colonic biopsies from IBS patients were found to produce elevated levels of serine protease [89].
Positive_regulation (elevated) of Gene_expression (produce) of serine protease associated with spastic colon
20) Confidence 0.02 Published 2008 Journal Parasit Vectors Section Body Doc Link PMC2627840 Disease Relevance 0.35 Pain Relevance 0.34

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