INT71950

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Context Info
Confidence 0.31
First Reported 1997
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.31
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
NB-4 2
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 17 100.00 Very High Very High Very High
diclofenac 1 96.56 Very High Very High Very High
Potency 5 85.20 High High
Hippocampus 14 83.92 Quite High
COX2 1 25.00 Low Low
aspirin 28 5.00 Very Low Very Low Very Low
IPN 6 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
cerebral cortex 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 10 99.80 Very High Very High Very High
INFLAMMATION 6 75.00 Quite High
Convulsion 10 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 6 5.00 Very Low Very Low Very Low
Cancer 6 5.00 Very Low Very Low Very Low
Inflammatory Pain 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The nonuniversal requirement for interaction of the carboxylate group of certain NSAIDs with the Arg106 residue in hPGHS-2 is supported by the observation that the methyl ester derivative of indomethacin was a more potent inhibitor than indomethacin on both hPGHS-2 and hPGHS-2(R106E).
Positive_regulation (requirement) of hPGHS-2 Binding (interaction) of associated with cinod
1) Confidence 0.31 Published 1997 Journal Mol. Pharmacol. Section Abstract Doc Link 9351974 Disease Relevance 0.07 Pain Relevance 0.70
The activity of the cyclooxygenase-2 promoter is only dependent on the promoter-distal NF-?
Positive_regulation (dependent) of cyclooxygenase-2 promoter Binding (activity) of
2) Confidence 0.10 Published 2002 Journal BMC Mol Biol Section Body Doc Link PMC140029 Disease Relevance 0.05 Pain Relevance 0.04
B activity in NB-4 neuroblastoma cells is essential for cyclooxygenase-2 promoter activity
Positive_regulation (essential) of cyclooxygenase-2 promoter Binding (activity) of in NB-4 associated with neuroblastoma
3) Confidence 0.10 Published 2002 Journal BMC Mol Biol Section Body Doc Link PMC140029 Disease Relevance 0.18 Pain Relevance 0

General Comments

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