INT71952

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2005
Negated 1
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.09
Pain Relevance 2.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 9 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
opioid receptor 4 100.00 Very High Very High Very High
narcan 3 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
analgesia 2 96.72 Very High Very High Very High
MU agonist 2 96.64 Very High Very High Very High
Neurotransmitter 1 92.76 High High
Antinociceptive 1 91.36 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 2 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of the blockade of mu1-opioid and 5HT2A-serotonergic/alpha1-noradrenergic receptors on sweet-substance-induced analgesia.
Regulation (Effect) of Negative_regulation (blockade) of mu1-opioid associated with narcan, opioid and analgesia
1) Confidence 0.43 Published 2005 Journal Psychopharmacology (Berl.) Section Title Doc Link 15821952 Disease Relevance 0 Pain Relevance 0.57
These studies were undertaken to determine the effects of mu-opioid receptor depletion through irreversible alkylation on the dose-effect curve for heroin self-administration.
Spec (determine) Regulation (effects) of Negative_regulation (depletion) of mu-opioid receptor associated with opioid receptor
2) Confidence 0.23 Published 1998 Journal Drug Alcohol Depend Section Abstract Doc Link 9800143 Disease Relevance 0 Pain Relevance 0.05
Down-regulation of mu-opioid receptor by full but not partial agonists is independent of G protein coupling.
Neg (independent) Regulation (independent) of Negative_regulation (Down-regulation) of mu-opioid receptor associated with analgesic, agonist and opioid receptor
3) Confidence 0.16 Published 1997 Journal Mol. Pharmacol. Section Title Doc Link 9351981 Disease Relevance 0.09 Pain Relevance 1.25
Recent studies have indicated that CNS proteins of the RGS family, specific regulators of G protein signalling, may be involved in mu-opioid receptor desensitization in vivo.
Regulation (involved) of Negative_regulation (desensitization) of mu-opioid receptor associated with opioid receptor
4) Confidence 0.02 Published 2005 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 15830230 Disease Relevance 0 Pain Relevance 0.31

General Comments

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