INT71970

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Context Info
Confidence 0.14
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 0.49
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Adcyap1r1) endosome (Adcyap1r1) signal transduction (Adcyap1r1)
plasma membrane (Adcyap1r1) cytoplasm (Adcyap1r1) signal transducer activity (Adcyap1r1)
Anatomy Link Frequency
sinus 1
Adcyap1r1 (Mus musculus)
Pain Link Frequency Relevance Heat
Neuropeptide 17 92.24 High High
imagery 28 91.92 High High
cINOD 2 89.76 High High
cytokine 14 84.64 Quite High
antagonist 26 83.16 Quite High
agonist 20 81.60 Quite High
Glutamate 64 81.48 Quite High
tetrodotoxin 11 76.16 Quite High
addiction 4 45.16 Quite Low
Kinase C 6 25.92 Quite Low
Disease Link Frequency Relevance Heat
Arrhythmias 2 Under Development 4 94.40 High High
INFLAMMATION 17 89.52 High High
Apoptosis 4 62.76 Quite High
Death 18 62.40 Quite High
Ganglion Cysts 24 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 12 5.00 Very Low Very Low Very Low
Encephalitis 7 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 5 5.00 Very Low Very Low Very Low
Decapitation 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This data suggests that PACAP can modulate AMPA currents through a PAC1 receptor mediated activation of the AC/PKA signalling pathway.


Positive_regulation (activation) of PAC1 receptor
1) Confidence 0.14 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.06
Similarly, previous physiological studies are also consistent with the PAC1 receptor mediating many of the effects of PACAP in the SCN [16,22,45].
Positive_regulation (mediating) of PAC1 receptor
2) Confidence 0.14 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.23
The simplest explanation for our data is that PACAP modulate glutamatergic signalling through a PAC1 receptor mediated activation of AC activity.
Positive_regulation (activation) of PAC1 receptor
3) Confidence 0.14 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0
In the late night, photic stimulation of the PAC1 -/- mice produced phase delays instead of the usual phase advances and was not associated with any changes in mPer or Fos.
Positive_regulation (stimulation) of PAC1
4) Confidence 0.13 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1388226 Disease Relevance 0 Pain Relevance 0.07
PACAP-27 (0.01-0.3 nmol) injected into the sinus node artery increased followed by decreased sinus rate.
Positive_regulation (increased) of PACAP-27 in sinus
5) Confidence 0.11 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353360 Disease Relevance 0.17 Pain Relevance 0.19
at nM concentrations that is known to activate the high affinity PACAP receptor, PAC1 (Fig. 5E).


Positive_regulation (activate) of PAC1
6) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2885411 Disease Relevance 0.32 Pain Relevance 0.29

General Comments

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