INT71999

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.08
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnaq) signal transduction (Gnaq) plasma membrane (Gnaq)
GTPase activity (Gnaq) protein complex (Gnaq) signal transducer activity (Gnaq)
Anatomy Link Frequency
tail 2
Gnaq (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 1 99.00 Very High Very High Very High
agonist 64 98.08 Very High Very High Very High
antinociception 4 89.28 High High
Morphine 6 87.84 High High
Buprenorphine 4 87.28 High High
Analgesic 2 86.72 High High
methadone 4 86.68 High High
Opioid 5 85.96 High High
opioid receptor 2 75.00 Quite High
analgesia 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 1 82.88 Quite High
Starvation 1 37.52 Quite Low
Asthma 43 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
Occupational Lung Diseases 9 5.00 Very Low Very Low Very Low
Bronchospasm 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Airway Remodeling 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of alpha-subunits of Gi-protein classes, Gi1, Gi2, Gi3, Go1, Go2 and Gz, and those of the Gq-protein family, Gq and G11, was reduced by administration of antisense oligodeoxynucleotides (ODNs) complementary to sequences in their respective mRNAs.
Negative_regulation (reduced) of Gene_expression (expression) of Gq
1) Confidence 0.41 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275413 Disease Relevance 0.08 Pain Relevance 1.46
Western blot analyses of G protein alpha and beta subunits demonstrated that Galphaq and Galphai protein levels were decreased in PE-exposed tail artery membranes.
Negative_regulation (decreased) of Gene_expression (levels) of Galphaq in tail
2) Confidence 0.12 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.07
Specific changes in ASM cells relevant to GPCR signaling that are known to occur in culture include a rapid and progressive decrease in the expression of Gq-coupled receptors such as the m3 muscarinic acetylcholine receptor (m3 mAChR) [21] and the cysteinyl leukotriene type 1 receptor (CLT1R; Stuart Hirst, personal communication).
Negative_regulation (decrease) of Gene_expression (expression) of Gq
3) Confidence 0.05 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.03

General Comments

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