INT720

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2011
Negated 46
Speculated 11
Reported most in Abstract
Documents 807
Total Number 818
Disease Relevance 237.37
Pain Relevance 353.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (POMC) cell-cell signaling (POMC) cytoplasm (POMC)
extracellular space (POMC) generation of precursor metabolites and energy (POMC) signal transduction (POMC)
Anatomy Link Frequency
plasma 244
pituitary 30
cerebrospinal fluid 20
blood 15
melanocyte 15
POMC (Homo sapiens)
POMC - A2M (1)
Pain Link Frequency Relevance Heat
Enkephalin 1189 100.00 Very High Very High Very High
Pain 718 100.00 Very High Very High Very High
Opioid 623 100.00 Very High Very High Very High
narcan 501 100.00 Very High Very High Very High
cytokine 386 100.00 Very High Very High Very High
Morphine 291 100.00 Very High Very High Very High
opiate 247 100.00 Very High Very High Very High
Fibrositis 234 100.00 Very High Very High Very High
Serotonin 205 100.00 Very High Very High Very High
Neuropeptide 192 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 1909 100.00 Very High Very High Very High
Adenoma 224 100.00 Very High Very High Very High
Coronary Artery Disease 94 100.00 Very High Very High Very High
Shock 61 100.00 Very High Very High Very High
Heart Rate Under Development 38 100.00 Very High Very High Very High
Convulsion 29 100.00 Very High Very High Very High
Fetal Distress 21 100.00 Very High Very High Very High
Cluster Headache 18 100.00 Very High Very High Very High
Natriuresis 12 100.00 Very High Very High Very High
Blister 11 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a further 3 subjects beta-LPH and beta-endorphin levels as estimated by N- and C-terminal beta-LPH radioimmunoassay were elevated on waking compared with 01.00 h, suggesting a nyctohemeral rhythm.
Positive_regulation (elevated) of beta-endorphin
1) Confidence 0.70 Published 1981 Journal Brain Res. Section Abstract Doc Link 6261889 Disease Relevance 0 Pain Relevance 0.54
Auricular electroacupuncture (EA) increased plasma ACTH and beta-endorphin levels significantly in 10 patients receiving EA as an analgesic aid during surgery.
Positive_regulation (increased) of beta-endorphin in plasma associated with analgesic and electroacupuncture
2) Confidence 0.70 Published 1983 Journal Acta Endocrinol. Section Abstract Doc Link 6310920 Disease Relevance 0 Pain Relevance 0.37
Auricular electroacupuncture (EA) increased plasma ACTH and beta-endorphin levels significantly in 10 patients receiving EA as an analgesic aid during surgery.
Positive_regulation (increased) of ACTH in plasma associated with analgesic and electroacupuncture
3) Confidence 0.70 Published 1983 Journal Acta Endocrinol. Section Abstract Doc Link 6310920 Disease Relevance 0 Pain Relevance 0.36
Adrenocorticotropin (ACTH) levels in plasma increased rapidly to 105% above baseline within 5 minutes after intravenous injection of cocaine (30 mg) in cocaine-dependent men.
Positive_regulation (increased) of ACTH in plasma associated with cocaine
4) Confidence 0.70 Published 1992 Journal Neuropsychopharmacology Section Abstract Doc Link 1329800 Disease Relevance 0 Pain Relevance 0.62
Beta-lipotropin, but not beta-endorphin, plasma levels were found to be significantly elevated during surgery in the general anesthesia group, while no change was found in either peptide concentration in the spinal one.
Positive_regulation (elevated) of Beta-lipotropin in spinal associated with anesthesia
5) Confidence 0.70 Published 1987 Journal Life Sci. Section Abstract Doc Link 2960867 Disease Relevance 0.27 Pain Relevance 0.52
Beta-lipotropin, but not beta-endorphin, plasma levels were found to be significantly elevated during surgery in the general anesthesia group, while no change was found in either peptide concentration in the spinal one.
Positive_regulation (elevated) of beta-endorphin in spinal associated with anesthesia
6) Confidence 0.70 Published 1987 Journal Life Sci. Section Abstract Doc Link 2960867 Disease Relevance 0.27 Pain Relevance 0.52
Contrast medium causes the apparent increase in beta-endorphin levels in human cerebrospinal fluid following brain stimulation.
Positive_regulation (increase) of beta-endorphin in cerebrospinal fluid
7) Confidence 0.70 Published 1984 Journal Pain Section Title Doc Link 6097857 Disease Relevance 0.15 Pain Relevance 0.15
Stimulation of human periaqueductal gray for pain relief increases immunoreactive beta-endorphin in ventricular fluid.
Positive_regulation (increases) of beta-endorphin associated with pain, enkephalin and central grey
8) Confidence 0.70 Published 1979 Journal Science Section Title Doc Link 83674 Disease Relevance 0.64 Pain Relevance 0.76
Endocrinological data showed elevation of plasma cortisol and ACTH, and increased excretion of urinary 17-OHCS.
Positive_regulation (elevation) of ACTH in plasma
9) Confidence 0.70 Published 1993 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 8258941 Disease Relevance 1.12 Pain Relevance 0.17
Significant increases in ACTH and cortisol were observed after both antagonists, without an apparent dose-response relationship; however, both doses of nalmefene resulted in greater HPA axis activation than either dose of naloxone (ACTH: p <0.005).
Positive_regulation (increases) of ACTH associated with antagonist and narcan
10) Confidence 0.70 Published 1998 Journal Alcohol. Clin. Exp. Res. Section Abstract Doc Link 9802524 Disease Relevance 0.16 Pain Relevance 0.83
An increase in the peripheral plasma levels of beta-endorphin in humans after exercise has been noted by all investigators to date.
Positive_regulation (increase) of beta-endorphin in plasma
11) Confidence 0.70 Published 1985 Journal Med Sci Sports Exerc Section Abstract Doc Link 2984516 Disease Relevance 0 Pain Relevance 0.24
These results, therefore, suggest that neuroendocrine modulation of human immune expression may be a peripheral physiological function of Beta-endorphin which is mediated by mechanisms distinct from traditional opiate receptors.
Positive_regulation (mediated) of Beta-endorphin associated with opiate
12) Confidence 0.70 Published 1982 Journal Life Sci. Section Abstract Doc Link 6292642 Disease Relevance 0 Pain Relevance 0.36
An increase in serum cortisol and adrenocorticotropic hormone indicated the presence of Cushing's disease.
Positive_regulation (increase) of adrenocorticotropic hormone associated with disease
13) Confidence 0.70 Published 1991 Journal Jpn. J. Med. Section Abstract Doc Link 1920964 Disease Relevance 1.30 Pain Relevance 0.24
All groups had significant increases in plasma ACTH during surgery, which returned to control levels 22 h after the bypass.
Positive_regulation (increases) of ACTH in plasma
14) Confidence 0.70 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3036903 Disease Relevance 0.08 Pain Relevance 0.87
Group I (no DEX, no fentanyl) and group III (no DEX, fentanyl) patients had large similar increases in plasma ACTH, which peaked 2-4 h postbypass [400 +/- 83 (+/- SEM) pg/mL; 88 +/- 18 pmol/L].
Positive_regulation (increases) of ACTH in plasma associated with dexamethasone
15) Confidence 0.70 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3036903 Disease Relevance 0.07 Pain Relevance 0.89
The group II (DEX, no fentanyl) patients also had large increases in ACTH which were similar to those in groups I and III, except 2-4 h postbypass (183 +/- 91 pg/mL; 40 +/- 20 pmol/L).
Positive_regulation (increases) of ACTH associated with dexamethasone
16) Confidence 0.70 Published 1987 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 3036903 Disease Relevance 0.06 Pain Relevance 0.95
The same trigger mechanism also plays a role as a release stimulus for hormones such for beta-endorphin which is increased under physical exercise.
Positive_regulation (increased) of beta-endorphin
17) Confidence 0.70 Published 1992 Journal Ann. Acad. Med. Singap. Section Abstract Doc Link 1590652 Disease Relevance 1.39 Pain Relevance 1.13
Consumption of alcohol results in an increase in beta-endorphin level in those regions of the human brain, which are associated with a reward system.
Positive_regulation (increase) of beta-endorphin in brain associated with alcohol
18) Confidence 0.70 Published 2005 Journal Peptides Section Abstract Doc Link 15752586 Disease Relevance 0.24 Pain Relevance 0.48
However, more prolonged needling during transfusion at the intrahepatic vein was associated with an increase in fetal plasma cortisol (median increase 48 nmol/L; 95% Cl, 23-86) and beta-endorphin (207 pg/mL; 113-307) concentrations compared to transfusion at the placental cord insertion (p < 0.005 for both hormones).
Positive_regulation (increase) of beta-endorphin in plasma
19) Confidence 0.70 Published 1994 Journal Lancet Section Abstract Doc Link 7912391 Disease Relevance 0.21 Pain Relevance 0.20
Labyrinthine stimulation and cold pain inhibit feeding antral pressure activity, delay gastric emptying, and increase blood concentrations of beta-endorphin and norepinephrine.
Positive_regulation (increase) of beta-endorphin in blood associated with pain
20) Confidence 0.70 Published 1984 Journal Gastroenterology Section Abstract Doc Link 6090258 Disease Relevance 0.10 Pain Relevance 0.29

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