INT72000

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 3.12
Pain Relevance 5.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnaq) signal transduction (Gnaq) plasma membrane (Gnaq)
GTPase activity (Gnaq) protein complex (Gnaq) signal transducer activity (Gnaq)
Anatomy Link Frequency
artery 1
tail 1
nucleus 1
oocytes 1
Gnaq (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 2 99.00 Very High Very High Very High
fluoxetine 25 98.56 Very High Very High Very High
agonist 268 98.20 Very High Very High Very High
Catecholamine 8 94.96 High High
opioid receptor 15 94.20 High High
cytokine 16 93.68 High High
antagonist 72 92.00 High High
b2 receptor 2 90.92 High High
antinociception 5 89.28 High High
Morphine 7 87.84 High High
Disease Link Frequency Relevance Heat
Stress 49 99.20 Very High Very High Very High
Asthma 86 94.72 High High
Common Cold 2 94.16 High High
Depression 15 83.32 Quite High
Targeted Disruption 24 79.68 Quite High
Urological Neuroanatomy 5 75.00 Quite High
Occupational Lung Diseases 18 67.16 Quite High
Bordatella Infection 8 54.08 Quite High
Anxiety Disorder 24 53.52 Quite High
Sprains And Strains 3 52.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of alpha-subunits of Gi-protein classes, Gi1, Gi2, Gi3, Go1, Go2 and Gz, and those of the Gq-protein family, Gq and G11, was reduced by administration of antisense oligodeoxynucleotides (ODNs) complementary to sequences in their respective mRNAs.
Gene_expression (expression) of Gq
1) Confidence 0.75 Published 2001 Journal Brain Res. Bull. Section Abstract Doc Link 11275413 Disease Relevance 0.08 Pain Relevance 1.38
However, partial agonist activity of CGP7930 could be observed when IP production was measured in HEK293 cells co-expressing the GABAB receptor and the chimeric G-protein Gqi9 [3].
Gene_expression (expressing) of Gqi associated with agonist
2) Confidence 0.75 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.72
METHODS: In Xenopus oocytes, the authors replaced endogenous Gq protein with mouse Gq (expressed in Sf9 cells using baculovirus vectors).
Gene_expression (expressed) of Gq protein in oocytes
3) Confidence 0.47 Published 2002 Journal Anesthesiology Section Body Doc Link 12459671 Disease Relevance 0 Pain Relevance 0
As revealed by radioligand binding assays and immunoblot analysis, differences in the efficiency of coupling were not due to variations in the expression of receptors and Galphaq chimeras.
Gene_expression (expression) of Galphaq
4) Confidence 0.34 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10051738 Disease Relevance 0.05 Pain Relevance 0.39
In contrast, G alpha q expression levels were significantly lower in fluoxetine-treated mice.
Gene_expression (expression) of alpha q associated with fluoxetine
5) Confidence 0.32 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17287521 Disease Relevance 0.83 Pain Relevance 0.47
These findings suggest that compensatory changes in G alpha q expression occur in mice with persistently altered 5-HT2C pre-mRNA editing and provide an explanation for the dissociation between 5-HT2C receptor editing phenotypes and behavioral stress responses.
Gene_expression (expression) of alpha q associated with stress
6) Confidence 0.32 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17287521 Disease Relevance 0.77 Pain Relevance 0.39
Enriched and nonenriched BALB/c mice exposed to early life stress also exhibited significantly increased expression of mRNA and protein encoding the G alpha q subunit of G-protein that couples to 5-HT2A/2C receptors.
Gene_expression (expression) of alpha q associated with stress
7) Confidence 0.25 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17287521 Disease Relevance 1.05 Pain Relevance 0.49
Western blot analyses of G protein alpha and beta subunits demonstrated that Galphaq and Galphai protein levels were decreased in PE-exposed tail artery membranes.
Gene_expression (levels) of Galphaq in tail
8) Confidence 0.19 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.07
Both levels of Galphai and Galphaq in depression patients were significantly higher than those in controls and were not reduced by treatments, although the severity was considerably relieved.
Gene_expression (levels) of Galphaq
9) Confidence 0.17 Published 2007 Journal J Affect Disord Section Body Doc Link 16919758 Disease Relevance 0 Pain Relevance 0
Heterologous desensitization of the rat tail artery contraction and inositol phosphate accumulation after in vitro exposure to phenylephrine is mediated by decreased levels of Galphaq and Galphai.
Gene_expression (levels) of Galphaq in artery
10) Confidence 0.17 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.33
Specific changes in ASM cells relevant to GPCR signaling that are known to occur in culture include a rapid and progressive decrease in the expression of Gq-coupled receptors such as the m3 muscarinic acetylcholine receptor (m3 mAChR) [21] and the cysteinyl leukotriene type 1 receptor (CLT1R; Stuart Hirst, personal communication).
Gene_expression (expression) of Gq
11) Confidence 0.09 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.03
Therefore, we could use drugs with distinct chemical structures (Figure S1) to activate Gs or Gs/Gq signaling of Rs1.
Gene_expression (signaling) of Gq
12) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.04
Replacing the C-terminus of Rs1 with 5-HT2C increases Gq signaling
Gene_expression (signaling) of Gq
13) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.05
Ligand-specific Gq signaling in Rs1
Gene_expression (signaling) of Gq
14) Confidence 0.07 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2267039 Disease Relevance 0 Pain Relevance 0.06
[180], has been shown to increase expression of either Gq or specific G?
Gene_expression (expression) of Gq
15) Confidence 0.06 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0.26 Pain Relevance 0.23
The proliferative effects of oxytocin appear to be Gq-linked and likely involve MAPK activation, leading to c-fos and c-jun induction.
Spec (appear) Gene_expression (appear) of Gq
16) Confidence 0.05 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0 Pain Relevance 0.04
Regulators of G protein signaling 4 and Galphaq protein levels in the hypothalamic paraventricular nucleus were not altered during fluoxetine treatment.
Gene_expression (levels) of Galphaq protein in nucleus associated with fluoxetine
17) Confidence 0.01 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12721328 Disease Relevance 0.07 Pain Relevance 0.79

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