INT72002

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Context Info
Confidence 0.35
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 0.20
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Gnaq) signal transduction (Gnaq) plasma membrane (Gnaq)
GTPase activity (Gnaq) protein complex (Gnaq) signal transducer activity (Gnaq)
Anatomy Link Frequency
tail 2
artery 1
oocytes 1
Gnaq (Mus musculus)
Pain Link Frequency Relevance Heat
local anesthetic 9 100.00 Very High Very High Very High
Catecholamine 3 94.96 High High
agonist 12 93.88 High High
Clonidine 3 77.36 Quite High
Serotonin 6 76.08 Quite High
Kinase C 1 56.56 Quite High
electroacupuncture 4 50.00 Quite Low
fluoxetine 2 50.00 Quite Low
Spinal cord 7 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 86.84 High High
Stress 3 61.76 Quite High
Repression 3 50.32 Quite High
Motor Neuron Diseases 62 50.00 Quite Low
Depression 2 50.00 Quite Low
Dementia 15 5.00 Very Low Very Low Very Low
Disease 13 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 8 5.00 Very Low Very Low Very Low
Spinal Muscular Atrophy 7 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
METHODS: In Xenopus oocytes, the authors replaced endogenous Gq protein with mouse Gq (expressed in Sf9 cells using baculovirus vectors).
Negative_regulation (replaced) of Gq protein in oocytes
1) Confidence 0.35 Published 2002 Journal Anesthesiology Section Body Doc Link 12459671 Disease Relevance 0 Pain Relevance 0
Inhibition of mammalian Gq protein function by local anesthetics.
Negative_regulation (Inhibition) of Gq protein associated with local anesthetic
2) Confidence 0.31 Published 2002 Journal Anesthesiology Section Title Doc Link 12459671 Disease Relevance 0 Pain Relevance 0.29
The goal of this study was to determine whether mammalian Gq protein is inhibited by local anesthetics.
Spec (whether) Negative_regulation (inhibited) of Gq protein associated with local anesthetic
3) Confidence 0.31 Published 2002 Journal Anesthesiology Section Abstract Doc Link 12459671 Disease Relevance 0 Pain Relevance 0.27
These data show that the reduced transmembrane signaling for the alpha1AR in tail artery after in vitro PE exposure is associated with decreases in Galphaq and Galphai protein levels.
Negative_regulation (decreases) of Galphaq in tail
4) Confidence 0.16 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.04
However, as both Gq and Gq11 are downregulated (?
Negative_regulation (downregulated) of Gq
5) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.20 Pain Relevance 0.03
Both levels of Galphai and Galphaq in depression patients were significantly higher than those in controls and were not reduced by treatments, although the severity was considerably relieved.
Neg (not) Negative_regulation (reduced) of Galphaq
6) Confidence 0.12 Published 2007 Journal J Affect Disord Section Body Doc Link 16919758 Disease Relevance 0 Pain Relevance 0
Western blot analyses of G protein alpha and beta subunits demonstrated that Galphaq and Galphai protein levels were decreased in PE-exposed tail artery membranes.
Negative_regulation (decreased) of Galphaq in tail
7) Confidence 0.12 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.07
Heterologous desensitization of the rat tail artery contraction and inositol phosphate accumulation after in vitro exposure to phenylephrine is mediated by decreased levels of Galphaq and Galphai.
Negative_regulation (decreased) of Galphaq in artery
8) Confidence 0.12 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9353415 Disease Relevance 0 Pain Relevance 0.33

General Comments

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